The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Combining Ixazomib With Subcutaneous Rituximab and Dexamethasone in Relapsed or Refractory Waldenström's Macroglobulinemia: Final Analysis of the Phase I/II HOVON124/ECWM-R2 Study
TL;DR: In this article , the authors investigated efficacy and toxicity of the less neurotoxic oral proteasome inhibitor ixazomib combined with rituximab, in patients with relapsed macroglobulinemia.
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Blast phenotype and comutations in acute myeloid leukemia with mutated NPM1 influence disease biology and outcome
TL;DR: These findings highlight biologic differences within immunophenotypically defined subgroups of NPM1-mutated AML that may impart prognostic significance.
Journal ArticleDOI
A B-cell receptor-related gene signature predicts survival in mantle cell lymphoma: results from the Fondazione Italiana Linfomi MCL-0208 trial
Riccardo Bomben,Simone Ferrero,Tiziana D'Agaro,Michele Dal Bo,Alessandro Re,Andrea Evangelista,Angelo Michele Carella,Alberto Zamò,Umberto Vitolo,Paola Omedè,Chiara Rusconi,Luca Arcaini,Luigi Rigacci,Stefano Luminari,Andrea Piccin,Delong Liu,Adrian Wiestner,Gianluca Gaidano,Sergio Cortelazzo,Marco Ladetto,Valter Gattei +20 more
TL;DR: This 6-gene signature associates with a poor clinical response in the context of the MCL- 0208 clinical trial, and is an independent predictor of short progression- free survival along with the Mantle Cell Lymphoma International Prognostic Index-combined score.
Journal ArticleDOI
Comprehensive analysis of peripheral T-cell and natural killer/T-cell lymphoma in Asian patients: A multinational, multicenter, prospective registry study in Asia.
Sang Eun Yoon,Yuqin Song,Seok Jin Kim,Dok Hyun Yoon,Tsai Yun Chen,Youngil Koh,Ka Won Kang,Ho Sup Lee,Kevin Tay,Soon Thye Lim,Michelle Poon,Cosphiadi Irawan,Wei-Li Zhao,Young Rok Do,Mark Hong Lee,Soo Chin Ng,Won Sik Lee,Ye Guo,Huilai Zhang,Hye Jin Kang,Hwan Jung Yun,Hyo Jung Kim,Daryl Tan Chen Lung,Jae Yong Kwak,Jae Joon Han,Yeung-Chul Mun,Sung Yong Oh,Hyeok Shim,Jung Hye Kwon,Byeong Seok Sohn,Seong Kyu Park,Jae Cheol Jo,Young Hyeh Ko,Zhu Jun,Won Seog Kim +34 more
TL;DR: In patients with PTCLs other than ENKTL, anthracycline-containing chemotherapies were widely used, but the outcome of those regimens was not satisfactory, and upfront autologous SCT was not significantly associated with survival benefit, either.
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Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears
Jan-Niklas Eckardt,Jan Moritz Middeke,Sebastian Riechert,Tim Schmittmann,Anas Shekh Sulaiman,Michael Kramer,Katja Sockel,Frank Kroschinsky,Ulrich Schuler,Johannes Schetelig,Christoph Röllig,Christian Thiede,Karsten Wendt,Martin Bornhäuser +13 more
TL;DR: In this paper, a multi-step DL approach was applied to automatically segment cells from bone marrow images, distinguish between AML samples and healthy controls with an area under the receiver operating characteristic (AUROC) of 0.9699, and predict the mutation status of Nucleophosmin 1 (NPM1)-one of the most common mutations in AML.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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