The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Jeremy S. Abramson,M. Lia Palomba,Leo I. Gordon,Matthew A. Lunning,Michael Wang,Jon E. Arnason,Amitkumar Mehta,Enkhtsetseg Purev,David G. Maloney,Charalambos Andreadis,Alison R. Sehgal,Scott R. Solomon,Nilanjan Ghosh,Tina Albertson,Jacob Garcia,Ana Kostic,Mary Mallaney,Ken Ogasawara,Kathryn Newhall,Yeonhee Kim,Daniel Li,Tanya Siddiqi +21 more
TL;DR: Overall safety and activity of liso-cel did not differ by dose level, with a high objective response rate, and a low incidence of grade 3 or worse cytokine release syndrome and neurological events in patients with relapsed or refractory large B-cell lymphomas.
Journal ArticleDOI
Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis
TL;DR: The cancer burden attributed to human papillomavirus showed the clearest relationship with country income level, and infection-attributable cancer incidence allows for refined geographic analyses and identification of populations with a high infection-associated cancer burden.
Journal ArticleDOI
2016 US lymphoid malignancy statistics by World Health Organization subtypes.
Lauren R. Teras,Carol DeSantis,James R. Cerhan,Lindsay M. Morton,Ahmedin Jemal,Christopher R. Flowers +5 more
TL;DR: Estimates of the total numbers of US lymphoid neoplasm cases by subtype as well as a detailed evaluation of incidence and survival statistics are presented, which can offer clues regarding their etiology.
Journal ArticleDOI
Infection in Organ Transplantation
TL;DR: Transplant infectious disease remains a key to the clinical and scientific investigation of organ transplantation and application of quantitative molecular microbial assays and advanced antimicrobial therapies have advanced care.
Journal ArticleDOI
International Consensus Classification of Myeloid Neoplasms and Acute Leukemia: Integrating Morphological, Clinical, and Genomic Data.
Daniel A. Arber,Attilio Orazi,Robert P. Hasserjian,Michael Horowitz,Katherine R. Calvo,Hans Michael Kvasnicka,Sa A. Wang,Adam Bagg,Tiziano Barbui,Susan Branford,Carlos E. Bueso-Ramos,Jorge E. Cortes,Paola Dal Cin,Courtney D. DiNardo,Hervé Dombret,Eric J. Duncavage,Benjamin L. Ebert,Elihu H. Estey,Fabio Facchetti,Kathryn Foucar,Naseema Gangat,Umberto Gianelli,Lucy A. Godley,Nicola Goekbuget,Jason Gotlib,Eva Hellström-Lindberg,Gabriela S. Hobbs,Roald Hoffmann,Elias Jabbour,Jean-Jacques Kiladjian,Richard A. Larson,Michelle M. Le Beau,Mignon L. Loh,Bob Löwenberg,Elizabeth Macintyre,Luca Malcovati,Charles G. Mullighan,Charlotte M. Niemeyer,Olatoyosi Odenike,Seishi Ogawa,Alberto Orfao,Elli Papaemmanuil,Francesco Passamonti,Kimmo Porkka,C H Pui,Jerald P. Radich,Andreas Reiter,María Rozman,Martina Rudelius,Michael R. Savona,Charles A. Schiffer,Annette Schmitt-Graeff,Akiko Shimamura,Jorge Sierra,Wendy Stock,Richard Stone,Martin S. Tallman,Juergen Thiele,Hwei-Fang Tien,Alexandar Tzankov,Alessandro M. Vannucchi,Paresh Vyas,Andrew H. Wei,Olga Weinberg,Agnieszka Wierzbowska,Mario Cazzola,Hartmut Döhner,Ayalew Tefferi +67 more
TL;DR: The authors, a group with expertise in the clinical, pathologic and genetic aspects of these disorders, developed the International Consensus Classification (ICC), aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.
References
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EBV positive mucocutaneous ulcer--a study of 26 cases associated with various sources of immunosuppression
TL;DR: EBV-positive mucocutaneous ulcer is proposed as a newly recognized clinicopathologic entity with Hodgkin-like features and a self-limited, indolent course, generally responding well to conservative management.
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Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
Sílvia Beà,Rafael Valdés-Mas,Alba Navarro,Itziar Salaverria,David Martín-García,Pedro Jares,Eva Giné,Magda Pinyol,Cristina Royo,Ferran Nadeu,Laura Conde,Manel Juan,Guillem Clot,Pedro Vizán,Luciano Di Croce,Diana A. Puente,Mónica López-Guerra,Alexandra Moros,Gaël Roué,Marta Aymerich,Neus Villamor,Lluis Colomo,Antonio Martinez,Alexandra Valera,José I. Martín-Subero,Virginia Amador,Luis Hernández,María Rozman,Anna Enjuanes,Pilar Forcada,Ana Muntañola,Elena Hartmann,María José Calasanz,Andreas Rosenwald,German Ott,Jesús M. Hernández-Rivas,Wolfram Klapper,Reiner Siebert,Adrian Wiestner,Wyndham H. Wilson,Dolors Colomer,Armando López-Guillermo,Carlos López-Otín,Xose S. Puente,Elias Campo +44 more
TL;DR: This study identifies molecular mechanisms contributing to MCL pathogenesis and offers potential targets for therapeutic intervention.
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Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry
Alessandro Pastore,Vindi Jurinovic,Robert Kridel,Eva Hoster,Annette M. Staiger,Annette M. Staiger,Monika Szczepanowski,Christiane Pott,Nadja Kopp,Mark A. Murakami,Heike Horn,Heike Horn,Ellen Leich,Alden A. Moccia,Anja Mottok,Ashwini Sunkavalli,Paul Van Hummelen,Matthew D. Ducar,Daisuke Ennishi,Hennady P. Shulha,Christoffer Hother,Joseph M. Connors,Laurie H. Sehn,Martin Dreyling,Donna Neuberg,Peter Möller,Alfred C. Feller,Martin L. Hansmann,Harald Stein,Andreas Rosenwald,German Ott,Wolfram Klapper,Michael Unterhalt,Wolfgang Hiddemann,Randy D. Gascoyne,David M. Weinstock,Oliver Weigert +36 more
TL;DR: This work aimed to improve risk stratification of patients receiving first-line immunochemotherapy by integrating gene mutations into a prognostic model by establishing a clinicogenetic risk model that included the Follicular Lymphoma International Prognostic Index (FLIPI) and Eastern Cooperative Oncology Group (ECOG) performance status.
Journal ArticleDOI
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
Davide Rossi,Silvia Rasi,Valeria Spina,Alessio Bruscaggin,Sara Monti,Carmela Ciardullo,Clara Deambrogi,Hossein Khiabanian,Roberto Serra,Francesco Bertoni,Francesco Forconi,Francesco Forconi,Luca Laurenti,Roberto Marasca,Michele Dal-Bo,Francesca Rossi,Pietro Bulian,Josep F. Nomdedeu,Giovanni Del Poeta,Valter Gattei,Laura Pasqualucci,Laura Pasqualucci,Raul Rabadan,Robin Foà,Riccardo Dalla-Favera,Gianluca Gaidano +25 more
TL;DR: This integrated mutational and cytogenetic model independently predicted survival, improved CLL prognostication accuracy compared with FISH karyotype, and was externally validated in an independent CLL cohort.
Journal ArticleDOI
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.
Rob A. Cairns,Javeed Iqbal,François Lemonnier,Can Küçük,Laurence de Leval,Jean-Philippe Jais,Marie Parrens,Antoine Martin,Luc Xerri,Pierre Brousset,Li Chong Chan,Wing C. Chan,Philippe Gaulard,Tak W. Mak +13 more
TL;DR: IDH2 mutations were identified in approximately 20% of angioimmunoblastic T- cell lymphomas (AITLs), but not in other peripheral T-cell lymphoma entities, and results were confirmed in an independent set of AITL patients, where the IDH2 mutation rate was approximately 45%.
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