The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
Cristina López,Kortine Kleinheinz,Sietse M. Aukema,Marius Rohde,Stephan H. Bernhart,Daniel Hübschmann,Rabea Wagener,Rabea Wagener,Umut H. Toprak,Umut H. Toprak,Francesco Raimondi,Markus Kreuz,Sebastian M. Waszak,Zhiqin Huang,Lina Sieverling,Nagarajan Paramasivam,Nagarajan Paramasivam,Julian Seufert,Stephanie Sungalee,Robert B. Russell,Julia Bausinger,Helene Kretzmer,Ole Ammerpohl,Anke K. Bergmann,Hans Binder,Arndt Borkhardt,Benedikt Brors,Alexander Claviez,Gero Doose,Lars Feuerbach,Andrea Haake,Martin-Leo Hansmann,Jessica I. Hoell,Michael Hummel,Jan O. Korbel,Chris Lawerenz,Dido Lenze,Bernhard Radlwimmer,Julia Richter,Philip Rosenstiel,Andreas Rosenwald,Markus Schilhabel,Harald Stein,Stephan Stilgenbauer,Peter F. Stadler,Monika Szczepanowski,Marc A. Weniger,Marc Zapatka,Roland Eils,Roland Eils,Peter Lichter,Markus Loeffler,Peter Möller,Lorenz Trümper,Wolfram Klapper,Steve Hoffmann,Ralf Küppers,Birgit Burkhardt,Matthias Schlesner,Reiner Siebert,Reiner Siebert +60 more
TL;DR: Interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation are unraveled.
Journal ArticleDOI
CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial
Yasuhiro Oki,Kevin R. Kelly,Ian W. Flinn,Manish R. Patel,Robert Gharavi,Anna Ma,Jefferson Parker,Amir Hafeez,David Tuck,Anas Younes +9 more
TL;DR: The tolerable safety profile and encouraging evidence of durable anti-tumor activity, particularly in MYC-altered patients, support the continued development of CUDC-907 in these populations of high unmet need.
Journal ArticleDOI
High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.
Matthias Papo,Eli L. Diamond,Fleur Cohen-Aubart,Jean-François Emile,Damien Roos-Weil,Nishant Gupta,Benjamin H. Durham,Neval Ozkaya,Ahmet Dogan,Gary A. Ulaner,Raajit K. Rampal,Jean-Emmanuel Kahn,Thomas Sené,Frédéric Charlotte,Baptiste Hervier,Caroline Besnard,Olivier A. Bernard,Catherine Settegrana,Nathalie Droin,Zofia Hélias-Rodzewicz,Zahir Amoura,Omar Abdel-Wahab,Julien Haroche +22 more
TL;DR: An unexpected and heretofore undescribed frequent occurrence of myeloid neoplasms among patients with ECD and MH is identified, highlighting the clinical importance of evaluating adults with histiocytosis for a concomitant myeloids neoplasm.
Journal ArticleDOI
KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study
Simone Ferrero,Davide Rossi,Andrea Rinaldi,Alessio Bruscaggin,Valeria Spina,Christian Winther Eskelund,Andrea Evangelista,Riccardo Moia,Ivo Kwee,Christina Dahl,Alice Di Rocco,Vittorio Stefoni,Fary Diop,Chiara Favini,Paola Ghione,Abdurraouf Mokhtar Mahmoud,Mattia Schipani,Arne Kolstad,Daniela Barbero,Domenico Novero,Marco Paulli,Alberto Zamo,Mats Jerkeman,Maria Gomes da Silva,Armando Santoro,A. L. Molinari,Andrés J.M. Ferreri,Kirsten Grønbæk,Andrea Piccin,Sergio Cortelazzo,Francesco Bertoni,Marco Ladetto,Gianluca Gaidano +32 more
TL;DR: The results confirm that TP53 disruption identifies a high-risk population characterized by poor sensitivity to conventional or intensified chemotherapy and provide the pivotal evidence that patients harboring KMT2D mutations share the same poor outcome as patients Harboring TP 53 disruption.
Journal ArticleDOI
Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas
Keisuke Kataoka,Hiroaki Miyoshi,Seiji Sakata,Akito Dobashi,Lucile Couronné,Lucile Couronné,Yasunori Kogure,Yasuharu Sato,Yasuharu Sato,Kenji Nishida,Yuka Gion,Yuichi Shiraishi,Hiroko Tanaka,Kenichi Chiba,Yosaku Watatani,Nobuyuki Kakiuchi,Yusuke Shiozawa,Tetsuichi Yoshizato,Kenichi Yoshida,Hideki Makishima,Masashi Sanada,Masahiro Onozawa,Takanori Teshima,Yumiko Yoshiki,Tadao Ishida,Kenshi Suzuki,Kazuyuki Shimada,Akihiro Tomita,Motohiro Kato,Yasunori Ota,Koji Izutsu,Ayako Demachi-Okamura,Yoshiki Akatsuka,Satoru Miyano,Tadashi Yoshino,Philippe Gaulard,Olivier Hermine,Olivier Hermine,Kengo Takeuchi,Koichi Ohshima,Seishi Ogawa +40 more
TL;DR: Findings illustrate unique genetic features of EBV-associated lymphomas, also suggesting a potential role of detecting PD-L1/PD-L2-involving lesions for these lymphomas to be effectively targeted by immune checkpoint blockade.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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