The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma.
Vassilis Atsaves,Nikolaos Tsesmetzis,Dimitris Chioureas,Loránd L. Kis,Loránd L. Kis,Vasiliki Leventaki,Elias Drakos,Theocharis Panaretakis,Dan Grandér,L. J. Medeiros,Ken H. Young,George Z. Rassidakis,George Z. Rassidakis,George Z. Rassidakis +13 more
TL;DR: PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma and is associated with central giant cell granuloma.
Journal ArticleDOI
Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
TL;DR: Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b, which is ubiquitously expressed on the surface of malignant B cells as discussed by the authors .
Journal ArticleDOI
Chronic lymphocytic leukaemia: from genetics to treatment.
TL;DR: Next-generation sequencing of the coding genome has identified the most common somatic genetic alterations associated with the pathogenesis of chronic lymphocytic leukaemia and how these genetic insights influence clinical management and the development of new therapeutic strategies for this disease is discussed.
Journal ArticleDOI
Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin.
Maria Pamela Dobay,François Lemonnier,Edoardo Missiaglia,Christian Bastard,David Vallois,Jean-Philippe Jais,Laurianne Scourzic,A. Dupuy,Virginie Fataccioli,Anaïs Pujals,Marie Parrens,Fabien Le Bras,Thérèse Rousset,Jean-Michel Picquenot,Nadine Martin,Corinne Haioun,Richard Delarue,Olivier A. Bernard,Mauro Delorenzi,Laurence de Leval,Philippe Gaulard +20 more
TL;DR: It is found that F-PTCL and other nodal PTCL with TFH phenotype share not only immunophenotypical features, but also similar clinical, genetic and molecular features with AITL, which supports the view that these lymphomas belong to the spectrum of a common disease.
Journal ArticleDOI
Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases
Bradley M. Haverkos,Zenggang Pan,Alejandro A. Gru,Aharon G. Freud,Rachel Rabinovitch,Meng Xu-Welliver,Brad Otto,Carlos Barrionuevo,Robert A. Baiocchi,Rosemary Rochford,Pierluigi Porcu +10 more
TL;DR: The universal association of ENKTL-NT with Epstein-Barr virus across all ethnic groups suggests a common pathogenesis and the poor response of this neoplasm to anthracycline-based therapy is consistent across all geographic areas.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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