The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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14-3-3 Proteins at the Crossroads of Neurodevelopment and Schizophrenia.
André Saraiva Leão Marcelo Antunes,Verônica M. Saia-Cereda,Fernanda Crunfli,Daniel Martins-de-Souza +3 more
TL;DR: The 14-3-3 family comprises multifunctional proteins that play a role in neurogenesis, neuronal migration, neuronal differentiation, synaptogenesis and dopamine synthesis as discussed by the authors.
Journal ArticleDOI
Differences between delusional disorder and schizophrenia: A mini narrative review
TL;DR: This relatively brief review is to synthesize what is known about the differences between two non-affective psychoses, schizophrenia and delusional disorder (DD), with respect to clinical, epidemiological, sociodemographic, and treatment response characteristics.
Journal ArticleDOI
Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes:
Lieve Desbonnet,Lieve Desbonnet,Colm M. P. O’Tuathaigh,Colm M. P. O’Tuathaigh,Clare O’Leary,Clare O’Leary,Rachel Cox,Orna Tighe,Emilie Petit,Steve Wilson,John L. Waddington,John L. Waddington +11 more
TL;DR: It is suggested that deletion of dys bindin-1A influences behaviours related to schizophrenia and anxiety more robustly in adolescence than in adulthood and that dysbindin- 1A influences stress-related responses in a sex-dependent manner.
Journal ArticleDOI
The psychosis risk timeline: can we improve our preventive strategies? Part 3: primary common pathways and preventive strategies
TL;DR: A review of evidence regarding common pathways by which many risk factors come together to influence the development of psychosis and a suggested overview model, a psychosis risk timeline are given.
Journal ArticleDOI
The efficacy of cariprazine on cognition: a post hoc analysis from phase II/III clinical trials in bipolar mania, bipolar depression, and schizophrenia
Roger S. McIntyre,David G. Daniel,Eduard Vieta,István Laszlovszky,Pascal Jean Denis Goetghebeur,Willie Earley,Mehul Patel +6 more
TL;DR: In this paper , the effect of cariprazine on cognitive symptom change across bipolar I disorder and schizophrenia was investigated in patients with depression and mania, and schizophrenia patients with high cognitive impairment.
References
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Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. 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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
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