The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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The Cannabinoid CB1 Receptor in Schizophrenia.
TL;DR: An overview of the endocannabinoid system is provided and how CB1 receptor dysfunction may contribute to the pathophysiology of schizophrenia is reviewed, drawing on the role of the receptor in regulating synaptic transmission and synaptic plasticity.
Journal ArticleDOI
Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample.
Dorota Frydecka,Kamila Kotowicz,Łukasz Gawęda,Katarzyna Prochwicz,Joanna Kłosowska,Joanna Rymaszewska,Agnieszka Samochowiec,Jerzy Samochowiec,Piotr Podwalski,Edyta Pawlak-Adamska,Elżbieta Szmida,Andrzej Cechnicki,Błażej Misiak +12 more
TL;DR: The findings imply that genetic liability related to aberrant dopamine transport might impact the association between TLEs and PLEs in subjects with high levels of ASEs.
Journal ArticleDOI
Using molecular imaging to understand early schizophrenia-related psychosis neurochemistry: a review of human studies
TL;DR: In vivo PET studies in the mentioned systems in the early course of psychosis (i.e. CHR and first-episode psychosis (FEP) are reviewed), and promising efforts involve the development of novel PET radiotracers targeting systems with growing interest in schizophrenia, like the nociceptive system and synaptic density.
Journal ArticleDOI
Consistent Exposure to Psychosocial Stressors and Progressive Intolerance to Stress in Individuals at Clinical High Risk for Psychosis
TL;DR: Results from the present study indicate an important role for exposure to stressors and increasing stress intolerance during psychosis pathogenesis, and findings indicating decreases in stress exposure may lead to more favorable outcomes provide a promising target for novel targeted interventions.
Journal ArticleDOI
Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery
Mark Z. Kos,Jubao Duan,Jubao Duan,Alan R. Sanders,Alan R. Sanders,Lucy Blondell,Eugene Drigalenko,Melanie A. Carless,Pablo V. Gejman,Pablo V. Gejman,Harald H H Göring,Mgs +11 more
TL;DR: The role of translational machinery in SZ pathogenesis is substantiated, providing insights into a possible dopaminergic mechanism disrupting mitochondrial function, and demonstrates the utility of disease-relevant functional perturbation in the study of complex genetic etiologies.
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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