The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
Citations
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Journal ArticleDOI
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Marianne O. Klein,Daniella S. Battagello,Ariel R. Cardoso,David N. Hauser,Jackson C. Bittencourt,Ricardo G. Correa +5 more
TL;DR: The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.
Journal ArticleDOI
30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis
Robin M. Murray,Robin M. Murray,Vishal Bhavsar,Giada Tripoli,Oliver D. Howes,Oliver D. Howes +5 more
TL;DR: The neurodevelopment hypothesis of schizophrenia morphed into the developmental risk factor model of psychosis and integrated new evidence concerning dysregulated striatal dopamine as the final step on the pathway linking risk factors to psychotic symptoms.
Journal ArticleDOI
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia
Sameer Jauhar,Sameer Jauhar,Matthew M. Nour,Matthew M. Nour,Mattia Veronese,Maria Rogdaki,Ilaria Bonoldi,Ilaria Bonoldi,Matilda Azis,Federico Turkheimer,Philip McGuire,Philip McGuire,Allan H. Young,Oliver D. Howes,Oliver D. Howes,Oliver D. Howes +15 more
TL;DR: Findings are consistent with a transdiagnostic role for dopamine dysfunction in the pathoetiology of psychosis and suggest dopamine synthesis capacity as a potential novel drug target for bipolar disorder and schizophrenia.
Journal ArticleDOI
Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis
TL;DR: In individuals with schizophrenia dopaminergic dysfunction is greater in dorsal compared to limbic subdivisions of the striatum, which is inconsistent with the mesolimbic hypothesis and identifies the dorsal striatum as a target for novel treatment development.
Journal ArticleDOI
Auditory verbal hallucinations and continuum models of psychosis: A systematic review of the healthy voice-hearer literature
TL;DR: Overall the results of the present systematic review support a continuum view rather than a diagnostic model, but cannot distinguish between ‘quasi’ and ‘fully’ dimensional models.
References
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Journal ArticleDOI
The Dopamine Hypothesis of Schizophrenia: A Review*
Journal ArticleDOI
The nature of dopamine dysfunction in schizophrenia and what this means for treatment
Oliver D. Howes,Joseph Kambeitz,Euitae Kim,Daniel Stahl,Mark Slifstein,Anissa Abi-Dargham,Shitij Kapur +6 more
TL;DR: The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release, and future drug development should focus on the control of presYNaptic dopamine synthesis and release capacity.
Journal ArticleDOI
The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes.
TL;DR: It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.
Journal ArticleDOI
Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia
Oliver D. Howes,Andrew J. Montgomery,M.-C. Asselin,Robin M. Murray,Isabel Valli,Paul Tabraham,Elvira Bramon-Bosch,Lucia Valmaggia,Louise Johns,Matthew R. Broome,Philip McGuire,Paul M. Grasby +11 more
TL;DR: Findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction.
Journal ArticleDOI
Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [11C]Raclopride
TL;DR: It is suggested that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems.
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