The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
Citations
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Journal ArticleDOI
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Marianne O. Klein,Daniella S. Battagello,Ariel R. Cardoso,David N. Hauser,Jackson C. Bittencourt,Ricardo G. Correa +5 more
TL;DR: The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.
Journal ArticleDOI
30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed Into the Developmental Risk Factor Model of Psychosis
Robin M. Murray,Robin M. Murray,Vishal Bhavsar,Giada Tripoli,Oliver D. Howes,Oliver D. Howes +5 more
TL;DR: The neurodevelopment hypothesis of schizophrenia morphed into the developmental risk factor model of psychosis and integrated new evidence concerning dysregulated striatal dopamine as the final step on the pathway linking risk factors to psychotic symptoms.
Journal ArticleDOI
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia
Sameer Jauhar,Sameer Jauhar,Matthew M. Nour,Matthew M. Nour,Mattia Veronese,Maria Rogdaki,Ilaria Bonoldi,Ilaria Bonoldi,Matilda Azis,Federico Turkheimer,Philip McGuire,Philip McGuire,Allan H. Young,Oliver D. Howes,Oliver D. Howes,Oliver D. Howes +15 more
TL;DR: Findings are consistent with a transdiagnostic role for dopamine dysfunction in the pathoetiology of psychosis and suggest dopamine synthesis capacity as a potential novel drug target for bipolar disorder and schizophrenia.
Journal ArticleDOI
Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis
TL;DR: In individuals with schizophrenia dopaminergic dysfunction is greater in dorsal compared to limbic subdivisions of the striatum, which is inconsistent with the mesolimbic hypothesis and identifies the dorsal striatum as a target for novel treatment development.
Journal ArticleDOI
Auditory verbal hallucinations and continuum models of psychosis: A systematic review of the healthy voice-hearer literature
TL;DR: Overall the results of the present systematic review support a continuum view rather than a diagnostic model, but cannot distinguish between ‘quasi’ and ‘fully’ dimensional models.
References
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Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis
Stephan Ruhrmann,Andreas Bechdolf,Kai-Uwe Kühn,Michael Wagner,Frauke Schultze-Lutter,Birgit Janssen,Kurt Maurer,Heinz Häfner,Wolfgang Gaebel,Hans-Jürgen Möller,Wolfgang Maier,Joachim Klosterkötter +11 more
TL;DR: Coadministration of amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning.
Journal ArticleDOI
Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis.
James M. Stone,Oliver D. Howes,Oliver D. Howes,Alice Egerton,Alice Egerton,Joseph Kambeitz,Paul Allen,David J. Lythgoe,Ruth L. O'Gorman,Mary A. McLean,Gareth J. Barker,Philip McGuire +11 more
TL;DR: The relationship between hippocampal glutamate and striatal dopamine systems is altered in people at high risk of psychosis, and the degree to which it is changed may be related to the risk of transition to psychosis.
Journal ArticleDOI
Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPET study using 123I-β-CIT and 123I-IBZM
Eveline Donnemiller,Christian Brenneis,Jörg Wissel,Christoph Scherfler,Werner Poewe,G. Riccabona,Gregor K. Wenning +6 more
TL;DR: It is suggested that nigrostriatal dysfunction may be detected using SPET following TBI despite relative structural preservation of the striatum, and possible clinical correlates and efficacy of dopaminergic therapy in patients with TBI seem justified.
Journal ArticleDOI
Morbid risk of schizophrenia in first-degree relatives of white and African-Caribbean patients with psychosis.
Gerard Hutchinson,Nori Takei,Thomas Fahy,Dinesh Bhugra,C. Gilvarry,Paul Moran,Paul Moran,Rosemarie Mallett,Pak C. Sham,Julian Leff,Robin M. Murray +10 more
TL;DR: It is suggested that the second-generation African–Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Great Britain.
Journal ArticleDOI
Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure.
TL;DR: Single‐unit extracellular recordings show that a prolonged inescapable mild stressor can induce plastic changes that attenuate the DA system response to acute stress.
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