The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review
Gabriela Novak,Mary V. Seeman +1 more
TL;DR: The aim of this paper is to address the potential role of dopamine in schizophrenia in general and, in particular, in the fluctuations in schizophrenia symptoms, and to review recent research into schizophrenia etiology.
Journal ArticleDOI
Illness Phase as a Key Assessment and Intervention Window for Psychosis
Christian G. Kohler,Daniel H. Wolf,Anissa Abi-Dargham,Alan Anticevic,Youngsun T. Cho,Clara Fonteneau,Roberto Gil,Ragy R. Girgis,David Gray,Jack Grinband,Jonathan A. Javitch,Joshua T. Kantrowitz,John H. Krystal,Jeffrey A. Lieberman,John D. Murray,Mohini Ranganathan,Nicole Santamauro,Jared X. Van Snellenberg,Zailyn Tamayo,Ruben C. Gur,Raquel E. Gur,Monica E. Calkins +21 more
TL;DR: In this paper , a phase-specific biomarkers of illness phase and brain development can be incorporated into current strategies for large-scale research and clinical programs implementing coordinated specialty care, highlighting working memory and D1 dysfunction as early treatment targets.
Journal ArticleDOI
Efficacy, safety, and tolerability of ulotaront (SEP-363856, a trace amine-associated receptor 1 agonist) for the treatment of schizophrenia and other mental disorders: a systematic review of preclinical and clinical trials
Gia Han Le,Emily S. Gillissie,Taeho Greg Rhee,Bing Cao,Yazen Alnefeesi,Ziji Guo,Joshua D. Di Vincenzo,Muhammad Youshay Jawad,Ranuk Ramachandra,Leanna M.W. Lui,Roger S. McIntyre +10 more
TL;DR: In this paper , a systematic review of the available evidence on a TAAR1 agonist, ulotaront, as a treatment for schizophrenia was conducted, and three clinical, two comparative, and five preclinical studies were identified.
Journal ArticleDOI
Psychophysiological stress-reactivity in clinical and non-clinical voice-hearers.
David Baumeister,David Baumeister,Toby Pillinger,Oliver D. Howes,Emmanuelle Peters,Emmanuelle Peters +5 more
TL;DR: In this paper, the authors investigated whether dysregulated psychophysiological stress-reactivity is specifically associated with auditory verbal hallucinations (AVHs) or psychosis more generally by comparing voice-hearers with and without a need for care.
Posted ContentDOI
Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function
TL;DR: In this paper, the authors leveraged chemogenetics and conditional gene silencing and found that presynaptic Gq-coupled receptor activation, induced by either hM3Dq or mGluR5 activation, drives biphasic DAT trafficking in striatum.
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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