The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Age-dependent divergent interactions between CX3CR1 absence and MK- 801 neonatal administration in a novel “dual hit” schizophrenia model
TL;DR: In this paper , the diathesis-stress model of schizophrenia posits that a constitutive factor increases the vulnerability to secondary stressors, and the fractalkine receptor (CX3CR1) depletion and MK-801 treatment had a synergistic effect, increasing neuronal apoptosis and overall mortality.
Posted ContentDOI
Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster
Rita R. Fagan,Patrick J. Kearney,Dino Luethi,Nicholas C Bolden,Harald H. Sitte,Patrick Emery,Haley E. Melikian +6 more
TL;DR: In this article, the Drosophila melanogaster Rit2 ortholog, Ric, was used to test whether the DRSophila Ric ortholog impacts dDAT function, trafficking, and DA-dependent behaviors.
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Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes
TL;DR: In this article , the authors define pain and trauma experiences in childhood and adolescents, discuss the relationship between pain and traumas, consider the role of biological memory, decipher the relationship of pain and traumatic experiences using preclinical data, and examine the role the environment by introducing the importance of epigenetic processes.
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SERS determination of dopamine using metal–organic frameworks decorated with Ag/Au noble metal nanoparticle composite after azo derivatization with p-aminothiophenol
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Imaging epigenetics study of schizophrenia with structure-enforced collaborative regression
TL;DR: A novel structure-enforced collaborative regression model (SCoRe) is proposed to extract co-expressed discriminative features related to SZ from fMRI and DNA methylation data to fill the gap by jointly analyzing imaging and epigenetics data to study SZ.
References
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Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. 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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
TL;DR: In this relatively brief study, the apparently increased comparative risk of agranulocytosis requires that the use of clozapine be limited to selected treatment-resistant patients.
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
TL;DR: A number of recent improvements to theNHGRI Catalog of Published Genome-Wide Association Studies are presented, including novel ways for users to interact with the Catalog and changes to the curation infrastructure.
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Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
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