The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Troubles moteurs tardifs induits par antipsychotiques : mise au point
Hélène Denizot,Benjamin Rolland,Caroline Nijhout,Thomas Charpeaud,Isabelle Chereau,Pierre-Michel Llorca +5 more
TL;DR: La prevalence des TMTA est elevee et l’evolution habituellement fluctuante, dont les preuves d’efficacite restent encore limitees, ou encore la chirurgie en cas of symptomes severes et resistants.
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Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia
M Guardiola-Ripoll,Alejandro Sotero-Moreno,Carmen Almodóvar-Payá,Noemí Hostalet,Amalia Guerrero-Pedraza,Nuria Ramiro,Jordi Ortiz-Gil,Bárbara Arias,Mercè Madre,Joan Soler-Vidal,Raymond Salvador,Peter J. McKenna,Edith Pomarol-Clotet,Mar Fatjó-Vilas +13 more
TL;DR: In this paper , the brain correlates of DISC1 haplotypes associated with SZ through a functional neuroimaging genetics approach were assessed, and the results showed that the haplotypes exerted differential effects on n-back associated brain activity in a subsample of 70 HS compared to 70 patients.
Journal ArticleDOI
A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis
Julia Hatagami Marques,Leda Leme Talib,Lucas Hortêncio,Julio Cesar Andrade,Tânia Maria Alves,Mauricio H. Serpa,Guilherme L. Yamamoto,Martinus Theodorus van de Bilt,Wulf Rössler,Wagner F. Gattaz,Alexandre Andrade Loch +10 more
TL;DR: In this article , the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultra-high risk (UHR) mental state for psychosis was tested.
Journal ArticleDOI
Prolactin and morning cortisol concentrations in antipsychotic naïve first episode psychosis: A systematic review and meta-analysis
Claudia Aymerich,Borja Pedruzo,M. Pacho,Maria Laborda,Jon Herrero,Toby Pillinger,Robert A. McCutcheon,Daniel Alonso-Alconada,Marta Bordenave,Maria Martínez-Querol,Ainara Arnaiz,Javier Labad,Paolo Fusar-Poli,Miguel Angel Gonzalez-Torres,Ana Catalan +14 more
TL;DR: In this article , the authors investigated the effect of intra-group variability on prolactin and cortisol levels in antipsychotic naïve patients with first episode psychosis (FEP) and healthy controls (HC).
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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