The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Journal ArticleDOI
Catechol-O-methyltransferase gene expression in stress-induced and non-stress induced schizophrenia.
Ziba Aghamaleki-Sarvestani,Nasim Vousooghi,Mina Tabrizi,Mohammad Esmaeil Alipour,Javad Alaghband-Rad,Hamid Mostafavi-Abdolmaleky,Mohammad Reza Zarindast +6 more
TL;DR: Data supports that reduced blood catechol-O-methyltransferase expression, which may be associated with higher dopamine level, is involved both in stress-induced and non-stress–induced schizophrenia.
Book ChapterDOI
Big data and the goal of personalized health interventions
TL;DR: In this article , the authors describe the what, where, and how of big data, focusing on data sources and analytical approaches most relevant for mental health research, with examples of how big data can inform prediction, prevention, and treatment choices.
Journal ArticleDOI
New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse-Microglia Interaction.
Naotaka Izuo,Atsumi Nitta +1 more
TL;DR: The hypothesis that excessive synaptic pruning plays a role in the development of schizophrenia is introduced and a strategy for diagnosis and medication based on modulation of the interaction between microglia and synapses is suggested.
Journal ArticleDOI
A Novel Variant in Dopamine Receptor Type 2 Gene is Associated with Schizophrenia
Farina Hanif,Qurat-Ul-Ain Amir,Washdev Washdev,Fareena Bilwani,Shabana Usman Simjee,Zeba Haque +5 more
TL;DR: The study found significant association of a novel missense SNP of DRD2 at chr11:113412805 (C>T) with schizophrenia in Pakistani population, but a large-scale multicenter study will be required to confirm the association of this novel SNP with schizophrenia.
Journal ArticleDOI
Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of schizophrenia.
Noah Adavize Omeiza,Adewale G. Bakre,Benneth Ben-Azu,Abimbola A. Sowunmi,Halimat Amin Abdulrahim,Joseph Chimezie,Sodiq O. Lawal,Olusegun G. Adebayo,Abdullateef Isiaka Alagbonsi,Olugbenga Akinola,Amos O. Abolaji,Adegbuyi Oladele Aderibigbe +11 more
TL;DR: In this paper , the authors explored the neuro-therapeutic role of Carpolobia lutea ethanol extract in ketamine-induced schizophrenia-like symptoms in mice, and found that C. lutesa reverses the cardinal symptoms of ketamineinduced schizophrenia in a dose-dependent fashion by modulating the oxido-inflammatory and neurotransmitter-related mechanisms.
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Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. 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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
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