The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Age- and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and neurodevelopmental disorders.
TL;DR: In this article, the authors discuss existing preclinical studies that support their overall hypothesis that the sex-and age-specific impacts of stress on PV + interneurons contribute to differences in individual vulnerability to stress across the lifespan, particularly in regard to sex differences in the diagnostic rate of neurodevelopmental and neuropsychiatric diseases in clinical populations.
Journal ArticleDOI
Photoelectrochemical sensor based on zinc phthalocyanine semiconducting polymer dots for ultrasensitive detection of dopamine
TL;DR: Zhang et al. as discussed by the authors reported a convenience method to synthesize phthalocyanine polymer dots (Pdots), which dope ZnPc into a conjugated polymer poly[(9,9-di- n -octylfluorenyl-2,7-diyl)- alt -(benzo{2,1,3}thiadia-zol-4,8-di), and modified on an indium tin oxide (ITO) electrode by repeated immersion to develop an ultrasensitive PEC sensor for dopamine (DA) detection.
Journal ArticleDOI
Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.
Zarazuela Zolkipli-Cunningham,Jane C. Naviaux,Tomohiro Nakayama,Charlotte M. Hirsch,Jonathan M. Monk,Kefeng Li,Lin Wang,Thuy Le,Simone Meinardi,Donald R. Blake,Robert K. Naviaux +10 more
TL;DR: A recent study in mice was conducted to characterize the bioenergetic, metabolomic, breathomic, and behavioral features of acute hyperpurinergia triggered by systemic injection of the purinergic agonist and danger signal, extracellular ATP (eATP) as discussed by the authors.
Journal ArticleDOI
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms
Sergio Hidalgo,Sergio Hidalgo,Christian Castro,Rafaella V. Zárate,Benjamín P. Valderrama,James J L Hodge,Jorge M. Campusano +6 more
TL;DR: The data show that the dysb1 mutant exhibits some behavioral deficits that mirror some aspects of the endophenotypes associated with the negative symptoms of schizophrenia, and argues that at least part of the behavioral aspects associated with these symptoms could be explained by a serotonergic deficit.
Journal ArticleDOI
Systematic comparison of duration of untreated illness versus duration of untreated psychosis in relation to psychopathology and dysfunction in the Cavan-Monaghan first episode psychosis study (CAMFEPS)
Nnamdi Nkire,Paul Scully,David J. Browne,Patrizia A. Baldwin,Tara Kingston,Olabisi Owoeye,Anthony Kinsella,Eadbhard O'Callaghan,Vincent Russell,John L. Waddington,John L. Waddington,John L. Waddington +11 more
TL;DR: In this paper, the authors compared duration of untreated illness (DUI) with duration of treated psychosis (DUP) in prediction of impairment at first-episode psychosis and investigated the extent to which these relationships are influenced by premorbid features.
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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