The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Varenicline for cognitive impairment in people with schizophrenia: systematic review and meta-analysis
Timothy Tanzer,Shelukumar Shah,Catherine Benson,Veronica De Monte,Victoria Gore-Jones,Susan L. Rossell,Susan L. Rossell,Frances Dark,Steve Kisely,Dan Siskind,Catarina Drumonde Melo +10 more
TL;DR: Varenicline does not appear to be a useful target compound for improving cognitive impairment in schizophrenia and a trial would need over 2500 participants to be powered to show statistically significant findings.
Posted ContentDOI
The Effect Of Perinatal Brain Injury On Dopaminergic Function And Hippocampal Volume In Adult Life
Sean Froudist-Walsh,Michael A P Bloomfield,Mattia Veronese,Jasmin Kroll,Vyacheslav Karolis,Sameer Jauhar,Ilaria Bonoldi,Philip McGuire,Shitij Kapur,Robin M. Murray,Chiara Nosarti,Oliver D. Howes +11 more
TL;DR: This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and has implications for understanding the mechanism underlying cognitive impairments and neuropsychiatric disorders following very preterm birth.
Journal ArticleDOI
Association of serum BDNF levels with psychotic symptom in chronic patients with treatment-resistant depression in a Chinese Han population.
Xingbing Huang,Xiong Huang,Yanling Zhou,Hongbo He,Fang Mei,Bin Sun,Jair C. Soares,Xiang Yang Zhang +7 more
TL;DR: The findings suggest that BDNF may be involved in the pathophysiology of TRD, and its associated psychotic symptoms, especially thought disturbance, which is supported by consistent findings of lower serum BDNF levels in depressed patients.
Journal ArticleDOI
Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment.
Jiaen Ye,Feng Ji,Deguo Jiang,Xiaodong Lin,Guangdong Chen,Wei Zhang,Peiwei Shan,Li Zhang,Chuanjun Zhuo +8 more
TL;DR: It is hypothesized that the genetic profile of the dopaminergic system mediates both SCZ-associated motor deficits associated and antipsychotic drug-related adverse effects, thereby optimizing treatment strategies for SCZ patients.
Journal ArticleDOI
The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Jianbo Yu,Xufeng Liao,Yanzi Zhong,Yongqiang Wu,Xinsheng Lai,Huifeng Jiao,Min Yan,Yu Zhang,Chaolin Ma,Shunqi Wang +9 more
TL;DR: In this paper, the authors found that Tmem108 mutant mice exhibited glucose intolerance, insulin resistance, and disturbed metabolic homeostasis, and food and oxygen consumption decreased, and urine production increased, accompanied by weak fatigue resistance.
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
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The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Danielle Welter,Jacqueline A. L. MacArthur,Joannella Morales,Tony Burdett,Peggy Hall,Heather Junkins,Alan Klemm,Paul Flicek,Teri A. Manolio,Lucia A. Hindorff,Helen Parkinson +10 more
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Stress signalling pathways that impair prefrontal cortex structure and function
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