The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TLDR
A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 410 citations till now. The article focuses on the topics: Dopaminergic & Dopamine receptor D3.read more
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Acute or Chronic? A Stressful Question
TL;DR: A new conceptual framework could enable us to understand the determinants of a pro-adaptive versus maladaptive trajectory of stress response, and also to study the mechanism of rapid-acting antidepressants that target the glutamate system directly.
Journal ArticleDOI
Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia.
TL;DR: The dopamine system and the circuits that regulate it, focusing on the hippocampus, medial prefrontal cortex, thalamic nuclei, and medial septum, and the impact of stress are discussed.
Journal ArticleDOI
Childhood trauma and clinical high risk for psychosis.
Rachel Loewy,Sarah Corey,Felix Amirfathi,Sawsan Dabit,Daniel Fulford,Rahel Pearson,Jessica P.Y. Hua,Danielle A. Schlosser,Barbara K. Stuart,Daniel H. Mathalon,Sophia Vinogradov +10 more
TL;DR: It is demonstrated that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.
Journal ArticleDOI
Cognition and Reward Circuits in Schizophrenia: Synergistic, Not Separate
TL;DR: It is argued that deficits of cognition and reward processing interact, and this interaction is a core feature of schizophrenia, and the synthesis attempted here provides an impetus for a conceptual shift that links cognitive and motivational aspects of schizophrenia and that can lead to treatment approaches that seek to harmonize network interactions between the brain's cognitive and reward circuits with ameliorative effects in each behavioral domain.
Journal ArticleDOI
Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA).
Alice Egerton,Alice Egerton,Anna Murphy,Jacek Donocik,Adriana Anton,Adriana Anton,Gareth J. Barker,Gareth J. Barker,Tracy Collier,Tracy Collier,Bill Deakin,Richard Drake,Emma Eliasson,Richard Emsley,Richard Emsley,Catherine J Gregory,Kira Griffiths,Shitij Kapur,Shitij Kapur,Shitij Kapur,Laura Kassoumeri,Laura Kassoumeri,Laura Knight,Emily J B Lambe,Stephen M. Lawrie,Jane Lees,Shôn Lewis,David J. Lythgoe,David J. Lythgoe,Julian C. Matthews,Philip McGuire,Philip McGuire,Lily McNamee,Scott Semple,Alexander D Shaw,Krish D. Singh,Charlotte Stockton-Powdrell,Peter S. Talbot,Mattia Veronese,Mattia Veronese,Ernest H. Wagner,James T.R. Walters,Stephen R. Williams,James H. MacCabe,James H. MacCabe,Oliver D. Howes,Oliver D. Howes,Oliver D. Howes +47 more
TL;DR: The results provide partial further support for a role of ACC glutamate, but not striatal dopamine synthesis, in determining the nature of the response to antipsychotic medication.
References
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Biological insights from 108 schizophrenia-associated genetic loci
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Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
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