A
Andrea Maschio
Researcher at University of Michigan
Publications - 43
Citations - 7931
Andrea Maschio is an academic researcher from University of Michigan. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 26, co-authored 42 publications receiving 7208 citations. Previous affiliations of Andrea Maschio include National Institutes of Health.
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Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen,Karol Estrada,Guillaume Lettre,Sonja I. Berndt,Michael N. Weedon,Fernando Rivadeneira,Cristen J. Willer,Anne U. Jackson,Sailaja Vedantam,Soumya Raychaudhuri,Teresa Ferreira,Andrew R. Wood,Robert J. Weyant,Ayellet V. Segrè,Elizabeth K. Speliotes,Eleanor Wheeler,Nicole Soranzo,Ju-Hyun Park,Jian Yang,Daniel F. Gudbjartsson,Nancy L. Heard-Costa,Joshua C. Randall,Lu Qi,Albert V. Smith,Reedik Maegi,Tomi Pastinen,Liming Liang,Iris M. Heid,Jian'an Luan,Gudmar Thorleifsson,Thomas W. Winkler,Michael E. Goddard,Ken Sin Lo,Cameron D. Palmer,Tsegaselassie Workalemahu,Yurii S. Aulchenko,Åsa Johansson,M. Carola Zillikens,Mary F. Feitosa,Tõnu Esko,Toby Johnson,Shamika Ketkar,Peter Kraft,Massimo Mangino,Inga Prokopenko,Devin Absher,Eva Albrecht,Florian Ernst,Nicole L. Glazer,Caroline Hayward,Jouke-Jan Hottenga,Kevin B. Jacobs,Joshua W. Knowles,Zoltán Kutalik,Keri L. Monda,Ozren Polasek,Michael Preuss,Nigel W. Rayner,Neil R. Robertson,Valgerdur Steinthorsdottir,Jonathan Tyrer,Benjamin F. Voight,Fredrik Wiklund,Jianfeng Xu,Jing Hua Zhao,Dale R. Nyholt,Niina Pellikka,Markus Perola,John R. B. Perry,Ida Surakka,Mari-Liis Tammesoo,Elizabeth L. Altmaier,Najaf Amin,Thor Aspelund,Tushar Bhangale,Gabrielle Boucher,Daniel I. Chasman,Constance Chen,Lachlan J. M. Coin,Mark E. Cooper,Anna L. Dixon,Quince Gibson,Elin Grundberg,Ke Hao,M. Juhani Junttila,Lee M. Kaplan,Johannes Kettunen,Inke R. Koenig,Tony Kwan,Robert Lawrence,Douglas F. Levinson,Mattias Lorentzon,Barbara McKnight,Andrew P. Morris,Martina Mueller,Julius S. Ngwa,Shaun Purcell,Suzanne Rafelt,Rany M. Salem,Erika Salvi,Serena Sanna,Jianxin Shi,Ulla Sovio,John R. Thompson,Michael C. Turchin,Liesbeth Vandenput,Dominique J. Verlaan,Veronique Vitart,Charles C. White,Andreas Ziegler,Peter Almgren,Anthony J. Balmforth,Harry Campbell,Lorena Citterio,Alessandro De Grandi,Anna F. Dominiczak,Jubao Duan,Paul Elliott,Roberto Elosua,Johan G. Eriksson,Nelson B. Freimer,Eco J. C. de Geus,Nicola Glorioso,Shen Haiqing,Anna-Liisa Hartikainen,Aki S. Havulinna,Andrew A. Hicks,Jennie Hui,Wilmar Igl,Thomas Illig,Antti Jula,Eero Kajantie,Tuomas O. Kilpelaeinen,Markku Koiranen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Jaana Laitinen,Jianjun Liu,Marja-Liisa Lokki,Ana Marušić,Andrea Maschio,Thomas Meitinger,Antonella Mulas,Guillaume Paré,Alex N. Parker,John F. Peden,Astrid Petersmann,Irene Pichler,Kirsi H. Pietiläinen,Anneli Pouta,Martin Riddertrale,Jerome I. Rotter,Jennifer G. Sambrook,Alan R. Sanders,Carsten Oliver Schmidt,Juha Sinisalo,Jan Smit,Heather M. Stringham,G. Bragi Walters,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Laura Zagato,Lina Zgaga,Paavo Zitting,Helene Alavere,Martin Farrall,Wendy L. McArdle,Mari Nelis,Marjolein Peters,Samuli Ripatti,Joyce B. J. vVan Meurs,Katja K.H. Aben,Kristin G. Ardlie,Jacques S. Beckmann,John Beilby,Richard N. Bergman,Sven Bergmann,Francis S. Collins,Daniele Cusi,Martin den Heijer,Gudny Eiriksdottir,Pablo V. Gejman,Alistair S. Hall,Anders Hamsten,Heikki V. Huikuri,Carlos Iribarren,Mika Kähönen,Jaakko Kaprio,Sekar Kathiresan,Lambertus A. Kiemeney,Thomas D. Kocher,Lenore J. Launer,Terho Lehtimäki,Olle Melander,Thomas H. Mosley,Arthur W. Musk,Markku S. Nieminen,Christopher J. O'Donnell,Claes Ohlsson,Ben A. Oostra,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,John D. Rioux,Aila Rissanen,Carlo Rivolta,Heribert Schunkert,Alan R. Shuldiner,David S. Siscovick,Michael Stumvoll,Anke Toenjes,Jaakko Tuomilehto,Gert-Jan B. van Ommen,Jorma Viikari,Andrew C. Heath,Nicholas G. Martin,Grant W. Montgomery,Michael A. Province,Manfred Kayser,Alice M. Arnold,Larry D. Atwood,Eric Boerwinkle,Stephen J. Chanock,Panos Deloukas,Christian Gieger,Henrik Grönberg,Per Hall,Andrew T. Hattersley,Christian Hengstenberg,Wolfgang Hoffman,G. Mark Lathrop,Veikko Salomaa,Stefan Schreiber,Manuela Uda,Dawn M. Waterworth,Alan F. Wright,Themistocles L. Assimes,Inês Barroso,Albert Hofman,Karen L. Mohlke,Dorret I. Boomsma,Mark J. Caulfield,L. Adrienne Cupples,Jeanette Erdmann,Caroline S. Fox,Vilmundur Gudnason,Ulf Gyllensten,Tamara B. Harris,Richard B. Hayes,Marjo-Ritta Jarvelin,Vincent Mooser,Patricia B. Munroe,Willem H. Ouwehand,Brenda W.J.H. Penninx,Peter P. Pramstaller,Thomas Quertermous,Igor Rudan,Nilesh J. Samani,Tim D. Spector,Henry Voelzke,Hugh Watkins,James F. Wilson,Leif Groop,Talin Haritunians,Frank B. Hu,Robert C. Kaplan,Andres Metspalu,Kari E. North,David Schlessinger,Nicholas J. Wareham,David J. Hunter,Jeffrey R. O'Connell,David P. Strachan,H. Erich Schadt,Unnur Thorsteinsdottir,Leena Peltonen,André G. Uitterlinden,Peter M. Visscher,Nilanjan Chatterjee,Ruth J. F. Loos,Michael Boehnke,Mark I. McCarthy,Erik Ingelsson,Cecilia M. Lindgren,Gonçalo R. Abecasis,Kari Stefansson,Timothy M. Frayling,Joel N. Hirschhorn +289 more
TL;DR: In this paper, the authors show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, revealing patterns with important implications for genetic studies of common human diseases and traits.
Journal ArticleDOI
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Angelo Scuteri,Serena Sanna,Wei-Min Chen,Manuela Uda,Giuseppe Albai,James B. Strait,Samer S. Najjar,Ramaiah Nagaraja,Marco Orru,Gianluca Usala,Mariano Dei,Sandra Lai,Andrea Maschio,Fabio Busonero,Antonella Mulas,Georg Ehret,Ashley A Fink,Alan B. Weder,Richard S. Cooper,Pilar Galan,Aravinda Chakravarti,David Schlessinger,Antonio Cao,Edward G. Lakatta,Gonçalo R. Abecasis +24 more
TL;DR: In this paper, a genome-wide association scan was conducted to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia, and the results showed that common genetic variants in the FTO gene are associated with substantial changes in body weight.
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Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Manuela Uda,Renzo Galanello,Serena Sanna,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Wei-Min Chen,Gianluca Usala,Fabio Busonero,Andrea Maschio,Giuseppe Albai,Maria Grazia Piras,Natascia Sestu,Sandra Lai,Mariano Dei,Antonella Mulas,Laura Crisponi,Silvia Naitza,Isadora Asunis,Manila Deiana,Ramaiah Nagaraja,Lucia Perseu,Stefania Satta,Maria Dolores Cipollina,Carla Sollaino,Paolo Moi,Joel N. Hirschhorn,Joel N. Hirschhorn,Stuart H. Orkin,G. Abecasis,David Schlessinger,Antonio Cao +31 more
TL;DR: It is indicated that BCL11A variants, by modulating HbF levels, act as an important ameliorating factor of the β-thalassemia phenotype, and it is likely they could helpAmeliorate other hemoglobin disorders.
Journal ArticleDOI
Exome-wide association study of plasma lipids in > 300,000 individuals
Dajiang J. Liu,Gina M. Peloso,Gina M. Peloso,Haojie Yu,Adam S. Butterworth,Adam S. Butterworth,Xiao Wang,Anubha Mahajan,Danish Saleheen,Danish Saleheen,Connor A. Emdin,Connor A. Emdin,Dewan S. Alam,Alexessander Couto Alves,Philippe Amouyel,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Dominique Arveiler,Themistocles L. Assimes,Themistocles L. Assimes,Paul L. Auer,Usman Baber,Christie M. Ballantyne,Lia E. Bang,Marianne Benn,Joshua C. Bis,Michael Boehnke,Eric Boerwinkle,Eric Boerwinkle,Jette Bork-Jensen,Erwin P. Bottinger,Ivan Brandslund,Morris J. Brown,Fabio Busonero,Mark J. Caulfield,John C. Chambers,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Y. Eugene Chen,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,John M. C. Connell,Francesco Cucca,L. Adrienne Cupples,L. Adrienne Cupples,Scott M. Damrauer,Scott M. Damrauer,Gail Davies,Ian J. Deary,George Dedoussis,Joshua C. Denny,Anna F. Dominiczak,Marie-Pierre Dubé,Marie-Pierre Dubé,Tapani Ebeling,Gudny Eiriksdottir,Tõnu Esko,Tõnu Esko,Aliki-Eleni Farmaki,Mary F. Feitosa,Marco M Ferrario,Jean Ferrières,Ian Ford,Myriam Fornage,Paul W. Franks,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Ruth Frikke-Schmidt,Lars G. Fritsche,Philippe M. Frossard,Valentin Fuster,Valentin Fuster,Santhi K. Ganesh,Wei Gao,Melissa E. Garcia,Christian Gieger,Franco Giulianini,Mark O. Goodarzi,Harald Grallert,Niels Grarup,Leif Groop,Megan L. Grove,Vilmundur Gudnason,Torben Hansen,Torben Hansen,Tamara B. Harris,Caroline Hayward,Joel N. Hirschhorn,Joel N. Hirschhorn,Oddgeir L. Holmen,Jennifer E. Huffman,Yong Huo,Kristian Hveem,Sehrish Jabeen,Anne U. Jackson,Johanna Jakobsdottir,Marjo-Riitta Järvelin,Gorm B. Jensen,Marit E. Jørgensen,Marit E. Jørgensen,J. Wouter Jukema,Johanne Marie Justesen,Pia R. Kamstrup,Stavroula Kanoni,Fredrik Karpe,Frank Kee,Amit Khera,Amit Khera,Derek Klarin,Derek Klarin,Derek Klarin,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,Claudia Langenberg,Anne Langsted,Anne Langsted,Lenore J. Launer,Torsten Lauritzen,David C. Liewald,Li-An Lin,Allan Linneberg,Ruth J. F. Loos,Yingchang Lu,Xiangfeng Lu,Xiangfeng Lu,Reedik Mägi,Anders Mälarstig,Anders Mälarstig,Ani Manichaikul,Alisa K. Manning,Alisa K. Manning,Pekka Mäntyselkä,Eirini Marouli,Nicholas G. D. Masca,Nicholas G. D. Masca,Andrea Maschio,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Antonella Mulas,Martina Müller-Nurasyid,Patricia B. Munroe,Matt Neville,Jonas B. Nielsen,Sune F. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Børge G. Nordestgaard,Jose M. Ordovas,Jose M. Ordovas,Roxana Mehran,C.J. O'Donnell,C.J. O'Donnell,Marju Orho-Melander,Cliona Molony,Pieter Muntendam,Sandosh Padmanabhan,Colin N. A. Palmer,Dorota Pasko,Aniruddh P. Patel,Oluf Pedersen,Markus Perola,Markus Perola,Annette Peters,Charlotta Pisinger,Giorgio Pistis,Ozren Polasek,Ozren Polasek,Neil Poulter,Bruce M. Psaty,Bruce M. Psaty,Daniel J. Rader,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Alexander P. Reiner,Frida Renström,Frida Renström,Stephen S. Rich,Paul M. Ridker,John D. Rioux,Neil R. Robertson,Neil R. Robertson,Dan M. Roden,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Serena Sanna,Naveed Sattar,Naveed Sattar,Ellen M. Schmidt,Robert A. Scott,Peter S. Sever,Raquel S. Sevilla,Christian M. Shaffer,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Blair H. Smith,Blair H. Smith,Blair H. Smith,Sangeetha Somayajula,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kathleen Stirrups,Kathleen Stirrups,Nathan O. Stitziel,Konstantin Strauch,Heather M. Stringham,Praveen Surendran,Hayato Tada,Alan R. Tall,Hua Tang,Jean-Claude Tardif,Jean-Claude Tardif,Kent D. Taylor,Stella Trompet,Philip S. Tsao,Philip S. Tsao,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Natalie R. van Zuydam,Natalie R. van Zuydam,Anette Varbo,Anette Varbo,Tibor V. Varga,Jarmo Virtamo,Melanie Waldenberger,Nan Wang,Nicholas J. Wareham,Helen R. Warren,Peter Weeke,Peter Weeke,Joshua S. Weinstock,Jennifer Wessel,James G. Wilson,Peter W.F. Wilson,Peter W.F. Wilson,Ming Xu,Hanieh Yaghootkar,Robin Young,Eleftheria Zeggini,He Zhang,Neil S Zheng,Weihua Zhang,Yan Zhang,Wei Zhou,Yanhua Zhou,Magdalena Zoledziewska,Joanna M. M. Howson,John Danesh,John Danesh,John Danesh,Mark I. McCarthy,Mark I. McCarthy,Chad A. Cowan,Gonçalo R. Abecasis,Panos Deloukas,Panos Deloukas,Kiran Musunuru,Cristen J. Willer,Sekar Kathiresan +288 more
TL;DR: It is found that beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD), and only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and TG-lowering alleles involved in hepatic production of TG-rich lipoproteins tracked with higher liver fat, higher risk for T2D, and lower risk for CAD.
Journal ArticleDOI
New gene functions in megakaryopoiesis and platelet formation
Christian Gieger,Aparna Radhakrishnan,Ana Cvejic,Weihong Tang,Eleonora Porcu,Giorgio Pistis,Jovana Serbanovic-Canic,Ulrich Elling,Alison H. Goodall,Yann Labrune,Lorna M. Lopez,Reedik Mägi,Stuart Meacham,Yukinori Okada,Nicola Pirastu,Rossella Sorice,Alexander Teumer,Katrin Voss,Weihua Zhang,Ramiro Ramirez-Solis,Joshua C. Bis,David Ellinghaus,Martin Gögele,Jouke-Jan Hottenga,Claudia Langenberg,Peter Kovacs,Paul F. O'Reilly,So Youn Shin,Tõnu Esko,Jaana Hartiala,Stavroula Kanoni,Federico Murgia,Afshin Parsa,Jonathan Stephens,Pim van der Harst,C. Ellen van der Schoot,Hooman Allayee,Antony P. Attwood,Beverley Balkau,François Bastardot,Saonli Basu,Sebastian E. Baumeister,Ginevra Biino,Lorenzo Bomba,Amélie Bonnefond,François Cambien,John C. Chambers,Francesco Cucca,Pio D'Adamo,Gail Davies,Rudolf A. de Boer,Eco J. C. de Geus,Angela Döring,Paul Elliott,Jeanette Erdmann,David M. Evans,Mario Falchi,Wei Feng,Aaron R. Folsom,Ian H. Frazer,Quince Gibson,Nicole L. Glazer,Christopher J Hammond,Anna-Liisa Hartikainen,Susan R. Heckbert,Christian Hengstenberg,Micha Hersch,Thomas Illig,Ruth J. F. Loos,Jennifer Jolley,Kay-Tee Khaw,Brigitte Kühnel,Marie-Christine Kyrtsonis,Vasiliki Lagou,Heather Lloyd-Jones,Thomas Lumley,Massimo Mangino,Andrea Maschio,Irene Mateo Leach,Barbara McKnight,Yasin Memari,Braxton D. Mitchell,Grant W. Montgomery,Yusuke Nakamura,Matthias Nauck,Gerjan Navis,Ute Nöthlings,Ilja M. Nolte,David J. Porteous,Anneli Pouta,Peter P. Pramstaller,Janne Pullat,Susan M. Ring,Jerome I. Rotter,Daniela Ruggiero,Aimo Ruokonen,Cinzia Sala,Nilesh J. Samani,Jennifer G. Sambrook,David Schlessinger,Stefan Schreiber,Heribert Schunkert,James Scott,Nicholas L. Smith,Harold Snieder,John M. Starr,Michael Stumvoll,Atsushi Takahashi,W.H. Wilson Tang,Kent D. Taylor,Albert Tenesa,Swee Lay Thein,Anke Tönjes,Manuela Uda,Sheila Ulivi,Dirk J. van Veldhuisen,Peter M. Visscher,Uwe Völker,H.-Erich Wichmann,Kerri L. Wiggins,Gonneke Willemsen,Tsun-Po Yang,Jing Hua Zhao,Paavo Zitting,John Bradley,George Dedoussis,Paolo Gasparini,Stanley L. Hazen,Andres Metspalu,Mario Pirastu,Alan R. Shuldiner,L. Joost van Pelt,Jaap Jan Zwaginga,Dorret I. Boomsma,Ian J. Deary,Andre Franke,Philippe Froguel,Santhi K. Ganesh,Marjo-Riitta Järvelin,Nicholas G. Martin,Christa Meisinger,Bruce M. Psaty,Tim D. Spector,Nicholas J. Wareham,Jan Willem N. Akkerman,Marina Ciullo,Panos Deloukas,Andreas Greinacher,Steve Jupe,Naoyuki Kamatani,Jyoti Khadake,Jaspal S. Kooner,Josef M. Penninger,Inga Prokopenko,Derek L. Stemple,Daniela Toniolo,Lorenz Wernisch,Serena Sanna,Andrew A. Hicks,Augusto Rendon,Manuel A. R. Ferreira,Willem H. Ouwehand,Nicole Soranzo +162 more
TL;DR: A high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry is carried out, identifying 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation.