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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Detection of renin messenger RNA in rat tissues: increased sensitivity using an RNAse protection technique.
TL;DR: With the more sensitive RNAse protection technique, the initial results indicate more widespread expression of renin, messenger RNA (mRNA) being detected in aorta, adrenal, heart, lung and spleen.
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The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis
Antoni Bayes-Genis,Julio Núñez,Faiez Zannad,João Pedro Ferreira,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Gerasimos Filippatos,Chim C. Lang,Leong L. Ng,Piotr Ponikowski,Nilesh J. Samani,Dirk J. van Veldhuisen,Aeilko H. Zwinderman,Marco Metra,Josep Lupón,Adriaan A. Voors +16 more
TL;DR: The PCSK9-LDLR axis was associated with outcomes in patients with HF and future studies must assess whetherPCSK9 inhibition will result in better outcomes in HF.
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T594M variant of the epithelial sodium channel β-subunit gene and hypertension in individuals of African ancestry in South Africa
Benedicta Nkeh,Nilesh J. Samani,Danelle Badenhorst,Elena Libhaber,Pinhas Sareli,Gavin R. Norton,Angela J. Woodiwiss +6 more
TL;DR: The results do not support an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of African ancestry.
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Galectin 1 inhibits incorporation of vitronectin and chondroitin sulfate B into the extracellular matrix of human vascular smooth muscle cells
TL;DR: The results suggest that galectin-1 is likely to be involved in the ECM assembly affecting incorporation of some ECM components important for SMC behaviour.
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RANTES/CCL5 and Risk for Coronary Events: Results from the MONICA/KORA Augsburg Case-Cohort, Athero-Express and CARDIoGRAM Studies
Christian Herder,Wouter Peeters,Thomas Illig,Jens Baumert,Dominique P.V. de Kleijn,Frans L. Moll,Ulrike Poschen,Norman Klopp,Martina Müller-Nurasyid,Michael Roden,Michael Preuss,Mahir Karakas,Christa Meisinger,Barbara Thorand,Gerard Pasterkamp,Wolfgang Koenig,Themistocles L. Assimes,Panos Deloukas,Jeanette Erdmann,Hilma Holm,Sekar Kathiresan,Inke R. König,Ruth McPherson,Muredach P. Reilly,Robert Roberts,Nilesh J. Samani,Heribert Schunkert,Alexandre F.R. Stewart +27 more
TL;DR: The absence of associations between RantES serum levels, CCL5 genotypes and RANTES content in carotid plaques and either coronary artery disease or incident coronary events in the authors' cohorts suggests that RANTes may not be a novel coronary risk biomarker.