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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
Tove Fall,Sara Hägg,Sara Hägg,Alexander Ploner,Reedik Mägi,Krista Fischer,Harmen H.M. Draisma,Antti-Pekka Sarin,Antti-Pekka Sarin,Beben Benyamin,Beben Benyamin,Claes Ladenvall,Mikael Åkerlund,Mart Kals,Tõnu Esko,Christopher P. Nelson,Christopher P. Nelson,Marika Kaakinen,Ville Huikari,Massimo Mangino,Aline Meirhaeghe,Kati Kristiansson,Marja-Liisa Nuotio,Michael Kobl,Harald Grallert,Abbas Dehghan,Maris Kuningas,Paul S. de Vries,Renée F.A.G. de Bruijn,Sara M. Willems,Kauko Heikkilä,Karri Silventoinen,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Vanessa Legry,Vilmantas Giedraitis,Louisa Goumidi,Ann-Christine Syvänen,Konstantin Strauch,Wolfgang Koenig,Peter Lichtner,Christian Herder,Aarno Palotie,Aarno Palotie,Aarno Palotie,Cristina Menni,André G. Uitterlinden,Kari Kuulasmaa,Aki S. Havulinna,Luis A. Moreno,Marcela González-Gross,Alun Evans,David-Alexandre Trégouët,David-Alexandre Trégouët,John Yarnell,Jarmo Virtamo,Jean Ferrières,Giovanni Veronesi,Markus Perola,Dominique Arveiler,Paolo Brambilla,Lars Lind,Jaakko Kaprio,Jaakko Kaprio,Albert Hofman,Bruno H. Stricker,Cornelia M. van Duijn,M. Arfan Ikram,Oscar H. Franco,Dominique Cottel,Jean Dallongeville,Alistair S. Hall,Antti Jula,Martin D. Tobin,Brenda W.J.H. Penninx,Annette Peters,Christian Gieger,Nilesh J. Samani,Nilesh J. Samani,Grant W. Montgomery,John Whitfield,Nicholas G. Martin,Leif Groop,Leif Groop,Tim D. Spector,Patrik K. E. Magnusson,Philippe Amouyel,Dorret I. Boomsma,Peter M. Nilsson,Marjo-Riitta Järvelin,Valeriya Lyssenko,Valeriya Lyssenko,Andres Metspalu,David P. Strachan,Veikko Salomaa,Samuli Ripatti,Nancy L. Pedersen,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Erik Ingelsson,Erik Ingelsson +104 more
TL;DR: This study used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals to provide sex- and age-specific causal estimates on cardiovascular risk factors.
Journal ArticleDOI
Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden: A Collaborative Meta-Analysis
Kenneth Chan,Riyaz S. Patel,Riyaz S. Patel,Riyaz S. Patel,Paul J. Newcombe,Christopher P. Nelson,Atif Qasim,Stephen E. Epstein,Susan Burnett,Viola Vaccarino,A. Maziar Zafari,Svati H. Shah,Jeffrey L. Anderson,John F. Carlquist,Jaana Hartiala,Hooman Allayee,Kunihiko Hinohara,Bok-Soo Lee,Anna Erl,Katrina L. Ellis,Anuj Goel,Arne S. Schaefer,Nour Eddine El Mokhtari,Benjamin A. Goldstein,Mark A. Hlatky,Alan S. Go,Gong-Qing Shen,Yan Gong,Carl J. Pepine,Ross C. Laxton,John C. Whittaker,W.H. Wilson Tang,Julie A. Johnson,Qing K. Wang,Themistocles L. Assimes,Ute Nöthlings,Martin Farrall,Martin Farrall,Hugh Watkins,Hugh Watkins,A. Mark Richards,Vicky A. Cameron,Axel Muendlein,Heinz Drexel,Werner Koch,Jeong Euy Park,Akinori Kimura,Wei-feng Shen,Iain Cardiff Simpson,Stanley L. Hazen,Benjamin D. Horne,Elizabeth R. Hauser,Arshed A. Quyyumi,Muredach P. Reilly,Nilesh J. Samani,Shu Ye +55 more
TL;DR: The 9p21 locus shows convincing association with greater burden of CAD but not with MI in the presence of underlying CAD, adding further weight to the hypothesis that 9p 21 locus primarily mediates an atherosclerotic phenotype.
Journal ArticleDOI
Glycoprotein IIIa polymorphism and risk of myocardial infarction.
Nilesh J. Samani,David Lodwick +1 more
TL;DR: It is concluded that, in subjects, the PlA2 variant of platelet glycoprotein IIIa is not an important risk factor for myocardial infarction.
Journal ArticleDOI
Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.
Jackson Neville Colin,Dan Atar,Maria Borentain,Guenter Breithardt,Martin van Eickels,Matthias Endres,Uwe Fraass,Tim Friede,Hakima Hannachi,Salim Janmohamed,Joerg Kreuzer,Martin J Landray,Dominik Lautsch,Chantal Le Floch,Peter G. M. Mol,Huseyin Naci,Nilesh J. Samani,Anders Svensson,Cathrine Thorstensen,Jan G.P. Tijssen,Victoria Vandzhura,Andrew Zalewski,Paulus Kirchhof +22 more
TL;DR: A coordinated effort involving academia, regulators, industry, and payors will help to foster better and more effective conduct of clinical cardiovascular trials, supporting earlier availability of innovative therapies and better management of cardiovascular diseases.
Journal ArticleDOI
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
Akihiro Nomura,Hong-Hee Won,Amit Khera,Fumihiko Takeuchi,Kaoru Ito,Shane McCarthy,Connor A. Emdin,Derek Klarin,Pradeep Natarajan,Seyedeh M. Zekavat,Namrata Gupta,Gina M. Peloso,Ingrid B. Borecki,Tanya M. Teslovich,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,David J. Carey,Michael F. Murray,H. Lester Kirchner,Joseph B. Leader,Daniel R. Lavage,J. Neil Manus,Dustin N. Hartze,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Jyh-Ming Jimmy Juang,Chao A. Hsiung,Shih-Yi Lin,Jun-Sing Wang,Hayato Tada,Masa-aki Kawashiri,Akihiro Inazu,Masakazu Yamagishi,Tomohiro Katsuya,Eitaro Nakashima,Masahiro Nakatochi,Ken Yamamoto,Mitsuhiro Yokota,Yukihide Momozawa,Jerome I. Rotter,Eric S. Lander,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Cristen J. Willer,Gonçalo R. Abecasis,Danish Saleheen,Michiaki Kubo,Norihiro Kato,Yii-Der Ida Chen,Frederick E. Dewey,Sekar Kathiresan +64 more
TL;DR: In this article, the authors demonstrate that therapy that inhibit CETP (cholesteryl ester transfer protein) has failed to demonstrate a reduction in risk for coronary heart disease (CHD) human DNA sequence variants that truncate.