N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
Papers
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Posted ContentDOI
Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney
Louise V. Wain,Ahmad Vaez,Ahmad Vaez,Rick Jansen,Roby Joehanes,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul F. O'Reilly,Claudia P. Cabrera,Helen R. Warren,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Tõnu Esko,Tõnu Esko,Tõnu Esko,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola M. Del Greco,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Weihua Zhang,Jonathan Marten,Ilaria Gandin,Sarah E. Harris,Tatijana Zemunik,Yingchang Lu,Evangelos Evangelou,Evangelos Evangelou,Nabi Shah,Nabi Shah,Martin H. de Borst,Massimo Mangino,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Michael R. Barnes,Chiara Batini,John Beilby,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Morris Brown,Marco Brumat,Harry Campbell,John C. Chambers,John C. Chambers,John C. Chambers,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Martin Farrall,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,He Gao,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Albert Hofman,Elizabeth G. Holliday,Jennie Hui,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Borbala Mifsud,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Sandosh Padmanabhan,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Neil Poulter,Peter P. Pramstaller,Olli T. Raitakari,Meixia Ren,Meixia Ren,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Rodney J. Scott,Marc A. Seelen,Denis C. Shields,David S. Siscovick,Rossella Sorice,Alice Stanton,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Simon Thom,Ioanna Tzoulaki,Christophe Tzourio,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,John Attia,John Attia,Peter S. Sever,Stéphanie Debette,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Pim van der Harst,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,Caroline Hayward,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,C M Lindgren,C M Lindgren,Veronique Vitart,Nilesh J. Samani,Nilesh J. Samani,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,Markus Perola,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Andres Metspalu,Erik Ingelsson,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Christopher Newton-Cheh,Christopher Newton-Cheh,Patricia B. Munroe,Paul Elliott,Daniel I. Chasman,Aravinda Chakravarti,Joanne Knight,Andrew P. Morris,Andrew P. Morris,Daniel Levy,Martin D. Tobin,Harold Snieder,Mark J. Caulfield,Georg Ehret +279 more
TL;DR: 48 genes with evidence for involvement in BP regulation that are significant in multiple resources are identified and identified, and three novel kidney-specific signals were also detected.
Journal ArticleDOI
Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis.
Xiangyuan Pu,Kenneth H. Chan,Wei Yang,Qingzhong Xiao,Li Zhang,Andrew D. Moore,Chuan-ju Liu,Tom R. Webb,Mark J. Caulfield,Nilesh J. Samani,Jianhua Zhu,Shu Ye,Shu Ye +12 more
TL;DR: The ADAMts7 Ser217-to-Pro substitution as a result of ADAMTS7 polymorphism affects thrombospondin-1 degradation, thereby promoting atherogenesis through increased EC migration and tube formation.
Supplementary Material 7
Joshua C. Randall,Thomas W. Winkler,Zoltán Kutalik,Sonja I. Berndt,Anne U. Jackson,Keri L. Monda,Tuomas O. Kilpeläinen,Tõnu Esko,Reedik Mägi,Shengxu Li,Tsegaselassie Workalemahu,Mary F. Feitosa,Damien C. Croteau Chonka,Felix R. Day,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Adam E. Locke,Iain Mathieson,André Scherag,Sailaja Vedantam,Andrew R. Wood,Liming Liang,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Emmanouil T. Dermitzakis,Antigone S. Dimas,Fredrik Karpe,Josine L. Min,George Nicholson,Deborah J. Clegg,Thomas N. Person,Jon P. Krohn,Sabrina Bauer,Christa Buechler,Kristina Eisinger,Amélie Bonnefond,Philippe Froguel,Jouke-Jan Hottenga,Inga Prokopenko,Lindsay L. Waite,Tamara B. Harris,Albert V. Smith,Alan R. Shuldiner,Wendy L. McArdle,Mark J. Caulfield,Patricia B. Munroe,Henrik Grönberg,Yii-Der Ida Chen,Guo Li,Jacques S. Beckmann,Toby Johnson,Unnur Thorsteinsdottir,Maris Teder-Laving,Kay-Tee Khaw,Nicholas J. Wareham,Jing Hua Zhao,Najaf Amin,Ben A. Oostra,Aldi T. Kraja,Michael A. Province,L. Adrienne Cupples,Nancy L. Heard Costa,Jaakko Kaprio,Samuli Ripatti,Ida Surakka,Francis S. Collins,Jouko Saramies,Jaakko Tuomilehto,Antti Jula,Veikko Salomaa,Jeanette Erdmann,Christian Hengstenberg,Christina Loley,Heribert Schunkert,Claudia Lamina,H.-Erich Wichmann,Eva Albrecht,Christian Gieger,Andrew A. Hicks,Åsa Johansson,Peter P. Pramstaller,Sekar Kathiresan,Elizabeth K. Speliotes,Brenda W.J.H. Penninx,Anna-Liisa Hartikainen,Marjo-Riitta Järvelin,Ulf Gyllensten,Dorret I. Boomsma,Harry Campbell,James F. Wilson,Stephen J. Chanock,Martin Farrall,Anuj Goel,Carolina Medina-Gomez,Fernando Rivadeneira,Karol Estrada,André G. Uitterlinden,Albert Hofman,M. Carola Zillikens,Martin den Heijer,Lambertus A. Kiemeney,Andrea Maschio,Per Hall,Jonathan Tyrer,Alexander Teumer,Henry Völzke,Peter Kovacs,Anke Tönjes,Massimo Mangino,Tim D. Spector,Caroline Hayward,Igor Rudan,Alistair S. Hall,Nilesh J. Samani,Antony P. Attwood,Jennifer G. Sambrook,Joseph Hung,Lyle J. Palmer,Marja-Liisa Lokki,Juha Sinisalo,Gabrielle Boucher,Heikki V. Huikuri,Mattias Lorentzon,Claes Ohlsson,Niina Eklund,Johan G. Eriksson,Cristina Barlassina,Carlo Rivolta,Ilja M. Nolte,Harold Snieder,Melanie M. van der Klauw,Jana V. Van Vliet Ostaptchouk,Pablo V. Gejman,Jianxin Shi,Kevin B. Jacobs,Zhaoming Wang,Stephan J. L. Bakker,Irene Mateo Leach,Gerjan Navis,Pim van der Harst,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Jian Yang,Daniel I. Chasman,Paul M. Ridker,Lynda M. Rose,Terho Lehtimäki,Olli T. Raitakari,Devin Absher,Carlos Iribarren,Hanneke Basart,Kees Hovingh,Elina Hyppönen,Chris Power,Denise Anderson,John Beilby,Jennie Hui,Jennifer Jolley,Hendrik B. Sager,Stefan R. Bornstein,Peter Schwarz,Kati Kristiansson,Markus Perola,Jaana Lindström,Amy J. Swift,Matti Uusitupa,Mustafa Atalay,Timo A. Lakka,Rainer Rauramaa,Jennifer L. Bolton,Gerry Fowkes,Ross M. Fraser,Jackie F. Price,Krista Fischer,Kaarel KrjutÅ¡kov,Andres Metspalu,Evelin Mihailov,Claudia Langenberg,Jian'an Luan,Ken K. Ong,Peter S. Chines,Sirkka M. Keinanen Kiukaanniemi,Timo Saaristo,Sarah Edkins,Paul W. Franks,Göran Hallmans,Dmitry Shungin,Andrew D. Morris,Colin N. A. Palmer,Raimund Erbel,Susanne Moebus,Markus M. Nöthen,Sonali Pechlivanis,Kristian Hveem,Narisu Narisu,Anders Hamsten,Steve E. Humphries,Rona J. Strawbridge,Elena Tremoli,Harald Grallert,Barbara Thorand,Thomas Illig,Wolfgang Koenig,Martina Müller-Nurasyid,Annette Peters,Bernhard O. Boehm,Marcus E. Kleber,Winfried März,Bernhard R. Winkelmann,Johanna Kuusisto,Markku Laakso,Dominique Arveiler,Giancarlo Cesana,Kari Kuulasmaa,Jarmo Virtamo,John Yarnell,Diana Kuh,Andrew Wong,Lars Lind,Ulf de Faire,Bruna Gigante,Patrik K. E. Magnusson,Nancy L. Pedersen,George Dedoussis,Maria Dimitriou,Genovefa Kolovou,Stavroula Kanoni,Kathleen Stirrups,Lori L. Bonnycastle,Inger Njølstad,Tom Wilsgaard,Andrea Ganna,Emil Rehnberg,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Erik Ingelsson,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,David Schlessinger,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Mark I. McCarthy,Joel N. Hirschhorn,Lu Qi,Ruth J. F. Loos,Cecilia M. Lindgren,Kari E. North,Iris M. Heid +263 more
Journal ArticleDOI
Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure
Mintu Nath,Simon P. R. Romaine,Andrea Koekemoer,Stephen E. Hamby,Tom R. Webb,Christopher P. Nelson,Marcos Castellanos-Uribe,M. Papakonstantinou,Stefan D. Anker,Chim C. Lang,Marco Metra,Faiez Zannad,Gerasimos Filippatos,Dirk J. van Veldhuisen,John G.F. Cleland,Leong L. Ng,Sean T. May,Federica M. Marelli-Berg,Adriaan A. Voors,James A. Timmons,Nilesh J. Samani +20 more
TL;DR: This work investigated whether whole blood transcriptomic profiling can provide new mechanistic insights into cardiovascular (CV) mortality in CHF.
Journal ArticleDOI
Multimarker Profiling Identifies Protective and Harmful Immune Processes in Heart Failure: Findings from BIOSTAT-CHF
George Markousis-Mavrogenis,Jasper Tromp,Jasper Tromp,Wouter Ouwerkerk,Wouter Ouwerkerk,Joao Pedro Fereirra,S.D. Anker,S.D. Anker,John G.F. Cleland,Kenneth Dickstein,Gerasimos Filippatos,Chim C. Lang,Marco Metra,Nilesh J. Samani,R. A. de Boer,Dirk J. van Veldhuisen,Adriaan A. Voors,Peter van der Meer +17 more
TL;DR: In this article, the authors investigated the associations between the activation of diverse immune processes and outcomes in patients with heart failure and all-cause mortality at 2-year follow-up.