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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Remote ischaemic conditioning and remodelling following myocardial infarction: current evidence and future perspectives
TL;DR: The ongoing and planned clinical trials are discussed which are attempting to elucidate whether the protection imparted by rIC in the preclinical setting can be translated to the clinic and become a realistic weapon in the clinician’s armoury to tackle acute remodelling and heart failure post-MI.
Journal ArticleDOI
Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure
Riccardo M. Inciardi,Matteo Pagnesi,Carlo Lombardi,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Gerasimos Filippatos,Chim C. Lang,Leong L. Ng,Pierpaolo Pellicori,Piotr Ponikowski,Nilesh J. Samani,Faiez Zannad,Dirk J. van Veldhuisen,Scott D. Solomon,Adriaan A. Voors,Marco Metra +16 more
TL;DR: Changes in LA dimension may be a useful marker of response to treatment and improve risk stratification in patients with HF and was associated with an unfavourable outcome and was prevented by ACEi/ARBs uptitration.
Journal Article
SA gene and hypertension.
Nilesh J. Samani,D. Lodwick +1 more
TL;DR: Findings in this model raise the exciting possibilities that SA represents a major component of an important novel system regulating blood pressure, and it underlies a primary renal mechanism predisposing to hypertension.
Posted ContentDOI
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution
Anne E. Justice,Tugce Karaderi,Heather M. Highland,Kristin L. Young,Mariaelisa Graff,Yingchang Lu,Valérie Turcot,Paul L. Auer,Rebecca S. Fine,Xiuqing Guo,Claudia Schurmann,Adelheid Lempradl,Eirini Marouli,Anubha Mahajan,Thomas W. Winkler,Adam E. Locke,Carolina Medina-Gomez,Tõnu Esko,Sailaja Vedantam,Ayush Giri,Ken Sin Lo,Tamuno Alfred,Poorva Mudgal,Maggie C.Y. Ng,Nancy C Heard-Costa,Mary F. Feitosa,Alisa K. Manning,Sara M. Willems,Suthesh Sivapalaratnam,Gonçalo R. Abecasis,Dewan S. Alam,Matthew A. Allison,Philippe Amouyel,Zorayr Arzumanyan,Beverley Balkau,Lisa Bastarache,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Linda Broer,Amber A. Burt,Adam S. Butterworth,Mark J. Caulfield,Giancarlo Cesana,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Francis S. Collins,James P. Cook,Amanda J. Cox,David S. Crosslin,John Danesh,Paul I.W. de Bakker,Simon de Denus,Renée de Mutsert,George Dedoussis,Ellen W. Demerath,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Marcus Dörr,Fotios Drenos,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Myriam Fornage,Caroline S. Fox,Paul W. Franks,Nele Friedrich,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Giorgia Girotto,Mathias Gorski,Harald Grallert,Niels Grarup,Megan L. Grove,Stefan Gustafsson,Jeffrey Haessler,Torben Hansen,Andrew T. Hattersley,Caroline Hayward,Iris M. Heid,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Yi-Jen Hung,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Gail P. Jarvik,Yucheng Jia,Torben Jørgenson,Pekka Jousilahti,Johanne Marie Justesen,Bratati Kahali,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Peter Kovacs,Bernhard K. Krämer,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Wen-Jane Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Jian'an Luan,Leo-Pekka Lyytikäinen,Stuart MacGregor,Reedik Mägi,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas Masca,Mark I. McCarthy,Karina Meidtner,Evelin Mihailov,Leena Moilanen,Marie Moitry,Dennis O. Mook-Kanamori,Anna Morgan,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Narisu Narisu,Christopher P. Nelson,Matt J. Neville,Ioanna Ntalla,Jeffrey R. O'Connel,Katharine R. Owen,Oluf Pedersen,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Ailith Pirie,Ozren Polasek,Olli T. Raitakari,Asif Rasheed,Chelsea K. Raulerson,Rainer Rauramaa,Dermot F. Reilly,Alex P. Reiner,Paul M. Ridker,Manuel A. Rivas,Neil R. Robertson,Antonietta Robino,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Blair H. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Karin M. A. Swart,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Mina Torres,Emmanouil Tsafantakis,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Cornelia M. van Duijn,Mauno Vanhala,Rohit Varma,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,M. Carola Zillikens,Fernando Rivadeneira,Ingrid B. Borecki,John Andrew Pospisilik,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Karen L. Mohlke,Jerome I. Rotter,Zoltán Kutalik,Joel N. Hirschhorn,L. Adrienne Cupples,Ruth J. F. Loos,Kari E. North,Cecilia M. Lindgren +278 more
TL;DR: By examining variants often poorly tagged or entirely missed by genome-wide association studies, novel genes in fat distribution are implicate, stressing the importance of interrogating low-frequency and protein-coding variants.
Journal ArticleDOI
Influence of non-invasive measurements of arterial blood pressure in frequency and time-domain estimates of cardiac baroreflex sensitivity.
Stephen M. Smith,Nilesh J. Samani,Emily L. Sammons,Wendy E. Rathbone,John F. Potter,Stephen Bentley,Ronney B. Panerai +6 more
TL;DR: Spectral analysis of cardiac BRS showed a better agreement between estimates obtained from the Finapres and aortic ABP, and the influence of β-blockers on BRS estimates was investigated.