N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
Papers
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Journal ArticleDOI
A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease
Tianxiao Huan,Bin Zhang,Zhi Wang,Roby Joehanes,Jun Zhu,Andrew D. Johnson,Saixia Ying,Peter J. Munson,Nalini Raghavachari,Richard J. Wang,Poching Liu,Paul Courchesne,Shih-Jen Hwang,Themistocles L. Assimes,Ruth McPherson,Nilesh J. Samani,Heribert Schunkert,Qingying Meng,Christine Suver,Christopher J. O'Donnell,Jonathan M. J. Derry,Xia Yang,Daniel Levy +22 more
TL;DR: A network-driven integrative analysis not only identified CHD-related genes, but also defined network structure that sheds light on the molecular interactions of genes associated with CHD risk.
Journal ArticleDOI
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Patrick Linsel-Nitschke,Jörg Heeren,Zouhair Aherrahrou,Petra Bruse,Christian Gieger,Thomas Illig,Holger Prokisch,Katharina Heim,Angela Doering,Annette Peters,Thomas Meitinger,H.-Erich Wichmann,Anke Hinney,Thomas Reinehr,Christian L. Roth,Christian L. Roth,Jan R. Ortlepp,Mouhidien Soufi,Alexander M. Sattler,Jürgen R. Schaefer,Klaus Stark,Christian Hengstenberg,Arne S. Schaefer,Stefan Schreiber,Florian Kronenberg,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann +27 more
TL;DR: Rs599839 associates with decreased LDL-C and a lower risk of CAD, and appears to be mediated by increased sortilin expression and subsequently enhanced LDL-uptake into cells.
Journal ArticleDOI
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
Kyle M. Walsh,Veryan Codd,Ivan Smirnov,Terri Rice,Paul A. Decker,Helen M. Hansen,Thomas M. Kollmeyer,Matthew L. Kosel,Annette M. Molinaro,Lucie McCoy,Paige M. Bracci,Belinda S. Cabriga,Melike Pekmezci,Shichun Zheng,Joseph L. Wiemels,Alexander R. Pico,Tarik Tihan,Mitchell S. Berger,Susan M. Chang,Michael D. Prados,Daniel H. Lachance,Brian P. O'Neill,Hugues Sicotte,Jeanette E. Eckel-Passow,Pim van der Harst,John K. Wiencke,Nilesh J. Samani,Robert B. Jenkins,Margaret Wrensch +28 more
TL;DR: This paper identified a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genomewide association studies.
Journal ArticleDOI
Directional dominance on stature and cognition in diverse human populations
Peter K. Joshi,Tõnu Esko,Hannele Mattsson,Niina Eklund,Ilaria Gandin,Teresa Nutile,Anne U. Jackson,Claudia Schurmann,Albert V. Smith,Weihua Zhang,Yukinori Okada,Alena Stančáková,Jessica D. Faul,Wei Zhao,Traci M. Bartz,Maria Pina Concas,Nora Franceschini,Stefan Enroth,Veronique Vitart,Stella Trompet,Xiuqing Guo,Daniel I. Chasman,Jeffrey R. O'Connel,Tanguy Corre,Suraj S. Nongmaithem,Yuning Chen,Massimo Mangino,Daniela Ruggiero,Michela Traglia,Aliki-Eleni Farmaki,Tim Kacprowski,Andrew Bjonnes,Ashley van der Spek,Ying Wu,Anil K. Giri,Lisa R. Yanek,Lihua Wang,Edith Hofer,Cornelius A. Rietveld,Olga McLeod,Marilyn C. Cornelis,Cristian Pattaro,Niek Verweij,Clemens Baumbach,Abdel Abdellaoui,Helen R. Warren,Dragana Vuckovic,Hao Mei,Claude Bouchard,John R. B. Perry,Stefania Cappellani,Saira Saeed Mirza,Miles C. Benton,Ulrich Broeckel,Sarah E. Medland,Penelope A. Lind,Giovanni Malerba,Alexander W. Drong,Loic Yengo,Lawrence F. Bielak,Degui Zhi,Peter J. van der Most,Daniel Shriner,Reedik Mägi,Gibran Hemani,Tugce Karaderi,Zhaoming Wang,Tian Liu,Ilja Demuth,Jing Hua Zhao,Weihua Meng,Lazaros Lataniotis,Sander W. van der Laan,Jonathan P. Bradfield,Andrew R. Wood,Amélie Bonnefond,Tarunveer S. Ahluwalia,Leanne M. Hall,Erika Salvi,Seyhan Yazar,Lisbeth Carstensen,Hugoline G. de Haan,Mark Abney,Uzma Afzal,Matthew A. Allison,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,R. Graham Barr,Sebastian E. Baumeister,Daniel J. Benjamin,Sven Bergmann,Eric Boerwinkle,Erwin P. Bottinger,Archie Campbell,Aravinda Chakravarti,Yingleong Chan,Stephen J. Chanock,Constance Chen,Y.-D. Ida Chen,Francis S. Collins,John M. C. Connell,Adolfo Correa,L. Adrienne Cupples,George Davey Smith,Gail Davies,Marcus Dörr,Georg Ehret,Stephen B. Ellis,Bjarke Feenstra,Mary F. Feitosa,Ian Ford,Caroline S. Fox,Timothy M. Frayling,Nele Friedrich,Frank Geller,Generation Scotland,Irina Gillham-Nasenya,Omri Gottesman,Misa Graff,Francine Grodstein,Charles Gu,Chris Haley,Christopher J Hammond,Sarah E. Harris,Tamara B. Harris,Nicholas D. Hastie,Nancy L. Heard-Costa,Kauko Heikkilä,Lynne J. Hocking,Georg Homuth,Jouke-Jan Hottenga,Jinyan Huang,Jennifer E. Huffman,Pirro G. Hysi,M. Arfan Ikram,Erik Ingelsson,Anni Joensuu,Åsa Johansson,Pekka Jousilahti,J. Wouter Jukema,Mika Kähönen,Yoichiro Kamatani,Stavroula Kanoni,Shona M. Kerr,Nazir M. Khan,Philipp Koellinger,Heikki A. Koistinen,Manraj K. Kooner,Michiaki Kubo,Johanna Kuusisto,Jari Lahti,Lenore J. Launer,Rodney A. Lea,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Lars Lind,Marie Loh,Marja-Liisa Lokki,Stephanie J. London,Stephanie J. Loomis,Anu Loukola,Yingchang Lu,Thomas Lumley,Annamari Lundqvist,Satu Männistö,Pedro Marques-Vidal,Corrado Masciullo,Angela Matchan,Rasika A. Mathias,Koichi Matsuda,James B. Meigs,Christa Meisinger,Thomas Meitinger,Cristina Menni,Frank D. Mentch,Evelin Mihailov,Lili Milani,May E. Montasser,Grant W. Montgomery,Alanna C. Morrison,Richard H. Myers,Rajiv Nadukuru,Pau Navarro,Mari Nalis,Markku S. Nieminen,Ilja M. Nolte,George T. O'Connor,Adesola Ogunniyi,Sandosh Padmanabhan,Walter Palmas,James S. Pankow,Inga Patarčić,Francesca Pavani,Patricia A. Peyser,Kirsi H. Pietiläinen,Neil R Poulter,Inga Prokopenko,Sarju Ralhan,Paul Redmond,Stephen S. Rich,Harri Rissanen,Antonietta Robino,Lynda M. Rose,Richard J. Rose,Cinzia Sala,Babatunde L. Salako,Veikko Salomaa,Antti-Pekka Sarin,Richa Saxena,Helena Schmidt,Laura J. Scott,William R. Scott,Bengt Sennblad,Sudha Seshadri,Peter S. Sever,Smeeta Shrestha,Blair H. Smith,Jennifer A. Smith,Nicole Soranzo,Nona Sotoodehnia,Lorraine Southam,Alice Stanton,Maria G. Stathopoulou,Konstantin Strauch,Rona J. Strawbridge,Matthew Suderman,Nikhil Tandon,Sian Tsun Tang,Kent D. Taylor,Bamidele O. Tayo,Anna Maria Töglhofer,Maciej Tomaszewski,Natalia Tšernikova,Jaakko Tuomilehto,André G. Uitterlinden,Dhananjay Vaidya,Astrid van Hylckama Vlieg,Jessica van Setten,Tuula Vasankari,Sailaja Vedantam,Efthymia Vlachopoulou,Diego Vozzi,Eero Vuoksimaa,Melanie Waldenberger,Erin B. Ware,William Wentworth-Shields,John Whitfield,Sarah H. Wild,Gonneke Willemsen,Chittaranjan S. Yajnik,Jie Yao,Gianluigi Zaza,Xiaofeng Zhu,Rany M. Salem,Mads Melbye,Hans Bisgaard,Nilesh J. Samani,Daniele Cusi,David A. Mackey,Richard S. Cooper,Philippe Froguel,Gerard Pasterkamp,Struan F.A. Grant,Hakon Hakonarson,Luigi Ferrucci,Robert A. Scott,Andrew D. Morris,Colin N. A. Palmer,George Dedoussis,Panos Deloukas,Lars Bertram,Ulman Lindenberger,Sonja I. Berndt,Cecilia M. Lindgren,Nicholas J. Timpson,Anke Tönjes,Patricia B. Munroe,Thorkild I. A. Sørensen,Charles N. Rotimi,Donna K. Arnett,Albertine J. Oldehinkel,Sharon L.R. Kardia,Beverley Balkau,Giovanni Gambaro,Andrew P. Morris,Johan G. Eriksson,Margie Wright,Nicholas G. Martin,Steven C. Hunt,John M. Starr,Ian J. Deary,Lyn R. Griffiths,Henning Tiemeier,Nicola Pirastu,Jaakko Kaprio,Nicholas J. Wareham,Louis Pérusse,James G. Wilson,Giorgia Girotto,Mark J. Caulfield,Olli T. Raitakari,Dorret I. Boomsma,Christian Gieger,Pim van der Harst,Andrew A. Hicks,Peter Kraft,Juha Sinisalo,Paul Knekt,Magnus Johannesson,Patrik K. E. Magnusson,Anders Hamsten,Reinhold Schmidt,Ingrid B. Borecki,Erkki Vartiainen,Diane M. Becker,Dwaipayan Bharadwaj,Karen L. Mohlke,Michael Boehnke,Cornelia M. van Duijn,Dharambir K. Sanghera,Alexander Teumer,Eleftheria Zeggini,Andres Metspalu,Paolo Gasparini,Sheila Ulivi,Carole Ober,Daniela Toniolo,Igor Rudan,David J. Porteous,Marina Ciullo,Tim D. Spector,Caroline Hayward,Josée Dupuis,Ruth J. F. Loos,Alan F. Wright,Giriraj R. Chandak,Peter Vollenweider,Alan R. Shuldiner,Paul M. Ridker,Jerome I. Rotter,Naveed Sattar,Ulf Gyllensten,Kari E. North,Mario Pirastu,Bruce M. Psaty,David R. Weir,Markku Laakso,Vilmundur Gudnason,Atsushi Takahashi,John C. Chambers,Jaspal S. Kooner,David P. Strachan,Harry Campbell,Joel N. Hirschhorn,Markus Perola,Ozren Polasek,James F. Wilson +358 more
TL;DR: This study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
Journal ArticleDOI
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Santhi K. Ganesh,Vinicius Tragante,Wei Guo,Yiran Guo,Matthew B. Lanktree,Erin N. Smith,Toby Johnson,Berta Almoguera Castillo,John Barnard,Jens Baumert,Yen Pei C. Chang,Clara C. Elbers,Martin Farrall,Mary E. Fischer,Nora Franceschini,Tom R. Gaunt,Johannes M.I.H. Gho,Christian Gieger,Yan Gong,Aaron Isaacs,Marcus E. Kleber,Irene Mateo Leach,Caitrin W. McDonough,Matthijs F.L. Meijs,Olle Mellander,Cliona Molony,Ilja M. Nolte,Sandosh Padmanabhan,Tom S. Price,Ramakrishnan Rajagopalan,Jonathan A. Shaffer,Sonia Shah,Haiqing Shen,Nicole Soranzo,Peter J. van der Most,Erik P A Van Iperen,Jessica van Setten,Judith M. Vonk,Li Zhang,Amber L. Beitelshees,Gerald S. Berenson,Deepak L. Bhatt,Jolanda M. A. Boer,Eric Boerwinkle,Ben Burkley,Amber A. Burt,Aravinda Chakravarti,Wei Chen,Rhonda M. Cooper-DeHoff,Sean P. Curtis,Albert W. Dreisbach,David Duggan,Georg Ehret,Richard R. Fabsitz,Myriam Fornage,Ervin R. Fox,Clement E. Furlong,Ron T. Gansevoort,Marten H. Hofker,G. Kees Hovingh,Susan Kirkland,Kandice Kottke-Marchant,Abdullah Kutlar,Andrea Z. LaCroix,Taimour Y. Langaee,Yun Li,Honghuang Lin,Kiang Liu,Steffi Maiwald,Rainer Malik,Gurunathan Murugesan,Christopher Newton-Cheh,Christopher Newton-Cheh,Jeffery R. O'Connell,N. Charlotte Onland-Moret,Willem H. Ouwehand,Walter Palmas,Brenda W.J.H. Penninx,Carl J. Pepine,Mary Pettinger,Joseph F. Polak,Vasan S. Ramachandran,Vasan S. Ramachandran,Jane E. Ranchalis,Susan Redline,Paul M. Ridker,Lynda M. Rose,Hubert Scharnag,Hubert Scharnag,Nicholas J. Schork,Daichi Shimbo,Alan R. Shuldiner,Alan R. Shuldiner,Sathanur R. Srinivasan,Ronald P. Stolk,Herman A. Taylor,Barbara Thorand,Mieke D. Trip,Cornelia M. van Duijn,W. M. Monique Verschuren,Cisca Wijmenga,Bernhard R. Winkelmann,Sharon B. Wyatt,J. Hunter Young,Bernhard O. Boehm,Mark J. Caulfield,Daniel I. Chasman,Karina W. Davidson,Pieter A. Doevendans,Garret A. FitzGerald,John G. Gums,Hakon Hakonarson,Hans L. Hillege,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,John J.P. Kastelein,Wolfgang Koenig,Winfried März,Winfried März,Braxton D. Mitchell,Sarah S. Murray,Albertine J. Oldehinkel,Daniel J. Rader,Muredach P. Reilly,Alexander P. Reiner,Eric E. Schadt,Roy L. Silverstein,Roy L. Silverstein,Harold Snieder,Alice Stanton,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Nilesh J. Samani,Nilesh J. Samani,Andrew D. Johnson,Patricia B. Munroe,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Xiaofeng Zhu,Daniel Levy,Brendan J. Keating,Folkert W. Asselbergs +144 more
TL;DR: Two novel loci associated with BP are identified and multiple previously reported associations are confirmed, extending the understanding of genes involved in BP regulation and some of which may eventually provide new targets for therapeutic intervention.