N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Circulating stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction.
Damian J. Kelly,Sohail Q. Khan,Gillian Cockerill,Leong L. Ng,Matt M. Thompson,Nilesh J. Samani,Iain B. Squire +6 more
TL;DR: This work investigated the temporal profile of MMP‐3 and its relationship to LV dysfunction and prognosis following AMI and found that changes to cardiac matrix are central to ventricular remodelling after acute MI.
Journal ArticleDOI
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
A. Mesut Erzurumluoglu,Mengzhen Liu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Daniel R. Barnes,Gargi Datta,Gargi Datta,Carl A. Melbourne,Robin Young,Chiara Batini,Praveen Surendran,Tao Jiang,Sheikh Daud Adnan,Saima Afaq,Arpana Agrawal,Elisabeth Altmaier,Antonis C. Antoniou,Folkert W. Asselbergs,Clemens Baumbach,Laura J. Bierut,Sarah Bertelsen,Michael Boehnke,Michiel L. Bots,David M. Brazel,John C. Chambers,Jenny Chang-Claude,Jenny Chang-Claude,Chu Chen,Chu Chen,Janie Corley,Yi-Ling Chou,Sean P. David,Rudolf A. de Boer,Christiaan de Leeuw,Joe Dennis,Anna F. Dominiczak,Alison M. Dunning,Douglas F. Easton,Charles B. Eaton,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Tatiana Foroud,Alison Goate,Jian Gong,Hans J. Grabe,Jeffrey Haessler,Christopher A. Haiman,Göran Hallmans,Anke R. Hammerschlag,Sarah E. Harris,Andrew T. Hattersley,Andrew C. Heath,Chris Hsu,William G. Iacono,Stavroula Kanoni,Manav Kapoor,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Charles Kooperberg,Kari Kuulasmaa,Markku Laakso,Dongbing Lai,Claudia Langenberg,Nhung Le,Guillaume Lettre,Guillaume Lettre,Anu Loukola,Jian'an Luan,Pamela A. F. Madden,Massimo Mangino,Massimo Mangino,Riccardo E. Marioni,Eirini Marouli,Jonathan Marten,Nicholas G. Martin,Matt McGue,Kyriaki Michailidou,Kyriaki Michailidou,Evelin Mihailov,Alireza Moayyeri,Marie Moitry,Martina Müller-Nurasyid,Aliya Naheed,Matthias Nauck,Matt Neville,Matt Neville,Sune F. Nielsen,Kari E. North,Markus Perola,Markus Perola,Paul D.P. Pharoah,Giorgio Pistis,Tinca J. C. Polderman,Danielle Posthuma,Neil Poulter,Beenish Qaiser,Asif Rasheed,Alex P. Reiner,Alex P. Reiner,Frida Renström,Frida Renström,John P. Rice,Rebecca Rohde,Olov Rolandsson,Nilesh J. Samani,Maria Samuel,David Schlessinger,Steven Scholte,Robert A. Scott,Peter S. Sever,Peter S. Sever,Yaming Shao,Nick Shrine,Jennifer A. Smith,John M. Starr,Kathleen Stirrups,Kathleen Stirrups,Danielle Stram,Heather M. Stringham,Ioanna Tachmazidou,Jean-Claude Tardif,Jean-Claude Tardif,Deborah J. Thompson,Hilary A. Tindle,Vinicius Tragante,Stella Trompet,Valérie Turcot,Jessica Tyrrell,Ilonca Vaartjes,Andries R. van der Leij,Peter van der Meer,Tibor V. Varga,Niek Verweij,Niek Verweij,Henry Völzke,Nicholas J. Wareham,Helen R. Warren,David R. Weir,Stefan Weiss,Stefan Weiss,Leah Wetherill,Hanieh Yaghootkar,Ersin Yavas,Ersin Yavas,Yu Jiang,Fang Chen,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Wei Zhao,Kaixin Zhou,Philippe Amouyel,Stefan Blankenberg,Mark J. Caulfield,Rajiv Chowdhury,Francesco Cucca,Ian J. Deary,Panos Deloukas,Panos Deloukas,Panos Deloukas,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Marco M Ferrario,Jean Ferrières,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Philippe M. Frossard,Ian P. Hall,Caroline Hayward,Jan-Håkan Jansson,J. Wouter Jukema,Frank Kee,Satu Männistö,Andres Metspalu,Patricia B. Munroe,Børge G. Nordestgaard,Colin N. A. Palmer,Veikko Salomaa,Naveed Sattar,Tim D. Spector,David P. Strachan,Pim van der Harst,Eleftheria Zeggini,Danish Saleheen,Danish Saleheen,Adam S. Butterworth,Adam S. Butterworth,Louise V. Wain,Louise V. Wain,Gonçalo R. Abecasis,John Danesh,John Danesh,John Danesh,Martin D. Tobin,Martin D. Tobin,Scott I. Vrieze,Dajiang J. Liu,Joanna M. M. Howson +206 more
TL;DR: The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
Journal ArticleDOI
Determinants and Functional Significance of Myocardial Perfusion Reserve in Severe Aortic Stenosis
Christopher D Steadman,Michael Jerosch-Herold,Benjamin Grundy,Suzanne Rafelt,Leong L. Ng,Iain B. Squire,Nilesh J. Samani,Nilesh J. Samani,Gerry P McCann,Gerry P McCann +9 more
TL;DR: LV remodeling appears to be a more important determinant of impaired MPR than stenosis severity per se, and CMR-quantified MPR is independently associated with aerobic exercise capacity in severe AS.
Journal ArticleDOI
Analysis of Quantitative Trait Loci for Blood Pressure on Rat Chromosomes 2 and 13 Age-Related Differences in Effect
Nilesh J. Samani,Dominique Gauguier,Madeleine Vincent,Michael A. Kaiser,Marie-Thérèse Bihoreau,David Lodwick,Robert H. Wallis,Valerie Parent,Phillip Kimber,Fraser Rattray,John R. Thompson,Jean Sassard,Mark Lathrop +12 more
TL;DR: The findings provide important information on QTLs influencing blood pressure on rat chromosomes 2 and 13 that will be useful in localizing and identifying the causative genes and emphasize the importance of age being taken into account when the effects of individualQTLs on a trait that shows significant age-related changes are being analyzed.
Journal ArticleDOI
Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1
Daniel P. Gale,Karen Molyneux,David Wimbury,Patricia Higgins,Adam P. Levine,Ben Caplin,Anna Ferlin,Peiran Yin,Christopher P. Nelson,Horia Stanescu,Nilesh J. Samani,Robert Kleta,Xueqing Yu,Jonathan Barratt +13 more
TL;DR: It is demonstrated that common variation at C1GALT1 influences Gd-IgA1 level in the population, which independently associates with risk of progressive IgAN, and that the pathogenic importance of changes in IgA1 O-glycosylation may vary between white and Chinese patients with IgAN.