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Nilesh J. Samani

Researcher at University of Leicester

Publications -  836
Citations -  127518

Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.

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Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

Sander W. van der Laan, +72 more
- 30 Aug 2016 - 
TL;DR: Mendelian randomization analyses did not support a causal role of cystatin C in the etiology of CVD, and therapeutics targeted at lowering circulating cyStatin C are unlikely to be effective in preventing CVD.
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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Robert A. Scott, +162 more
TL;DR: A low-frequency missense variant in the gene encoding glucagon-like peptide-1 receptor, the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP 1R agonist therapies, and provided evidence that GLP2D agonists are not likely to be associated with an unacceptable increase in cardiovascular risk.
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Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

Stephen Newhouse, +14 more
- 01 Jul 2005 - 
TL;DR: This finding of association between a SNP near the promoter region and the severity of hypertension suggests that increased expression of WNK1 might contribute to BP variability and susceptibility to EH similar to the mechanism of hypertension observed in Gordon's syndrome.
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Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia

Nathan O. Stitziel, +45 more
- 01 Dec 2013 - 
TL;DR: This study diagnosed clinically unapparent cholesterol ester storage disease in the affected individuals from this kindred and addressed an outstanding question about risk of cardiovascular disease in LIPA E8SJM heterozygous carriers.

Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R. Wood, +444 more
TL;DR: The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.