N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Analysis of the Role of Angiotensinogen in Spontaneous Hypertension
David Lodwick,Michael A. Kaiser,Janet Harris,Frederic Cumin,Madeleine Vincent,Nilesh J. Samani +5 more
TL;DR: The findings suggest that pulse pressure, which significantly influences cardiovascular risk, has independent genetic determinants, and suggest that the effect of the angiotensinogen locus on this phenotype in the SHR may be mediated through a tissue-specific abnormality of angiotENSinogen gene expression.
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Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.
Marianne Barr,Scott M. MacKenzie,E Friel,Christine D. Holloway,D Wilkinson,Nick J.R. Brain,Mary C. Ingram,Robert Fraser,Morris J. Brown,Nilesh J. Samani,Mark J. Caulfield,Patricia B. Munroe,Martin Farrall,John Webster,David Clayton,Anna F. Dominiczak,John M. C. Connell,Eleanor Davies +17 more
TL;DR: This study strongly suggests that the impaired 11β-hydroxylase efficiency associated previously with the CYP11B2 −344 and intron conversion variants is because of linkage with these newly identified polymorphisms in CYP 11B1.
Journal ArticleDOI
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.
Akihiro Nomura,Connor A. Emdin,Hong-Hee Won,Gina M. Peloso,Pradeep Natarajan,Pradeep Natarajan,Diego Ardissino,John Danesh,Heribert Schunkert,Adolfo Correa,Matthew J. Bown,Nilesh J. Samani,Nilesh J. Samani,Jeanette Erdmann,Ruth McPherson,Hugh Watkins,Danish Saleheen,Roberto Elosua,Masa-aki Kawashiri,Hayato Tada,Namrata Gupta,Svati H. Shah,Daniel J. Rader,Stacey Gabriel,Amit Khera,Amit Khera,Sekar Kathiresan +26 more
TL;DR: Although familial sitosterolemia is traditionally considered as a recessive disorder, it is observed that heterozygous carriers of a LoF variantin ABCG5 had significantly increased sitosterol and LDL-C levels and a two-fold increase in risk of CAD.
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The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1
Matthias Prestel,Caroline Prell-Schicker,Tom R. Webb,Rainer Malik,Barbara Lindner,Natalie Ziesch,Monika Rex-Haffner,Simone Röh,Thanatip Viturawong,Manuel Lehm,Manuel Lehm,Michal Mokry,Hester M. den Ruijter,Saskia Haitjema,Yaw Asare,Flavia Söllner,Maryam Ghaderi Najafabadi,Redouane Aherrahrou,Mete Civelek,Nilesh J. Samani,Matthias Mann,Christof Haffner,Martin Dichgans +22 more
TL;DR: Targeted resequencing of the HDAC9 locus in patients with atherosclerotic stroke and controls supported candidacy of rs2107595 as the causative single nucleotide polymorphism, implying allele-specific transcriptional regulation of HDAC 9 via E2F3 and Rb1 as a major mechanism mediating vascular risk at rs210 7595.
Journal ArticleDOI
Exon repetition: a major pathway for processing mRNA of some genes is allele‐specific
TL;DR: It is demonstrated for the two best characterized examples that exon repetition is restricted to specific alleles of the affected genes and is determined in cis, and is not determined by exonic splicing signals, as had been suggested previously.