N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Genome-wide mapping of human loci for essential hypertension
Mark J. Caulfield,Patricia B. Munroe,J Pembroke,Nilesh J. Samani,Anna F. Dominiczak,Matthew A. Brown,N Benjamin,John Webster,Peter J. Ratcliffe,S O'Shea,Jeanette C. Papp,E Taylor,Richard Dobson,Jo Knight,Stephen Newhouse,J Hooper,Wai K. Lee,Nick J.R. Brain,David Clayton,G M Lathrop,Martin Farrall,John M. C. Connell +21 more
TL;DR: In this article, the results of a genome scan for hypertension in a large white European population were presented, which indicated that human essential hypertension has an oligogenic element (a few genes may be involved in determination of the trait) possibly superimposed on more minor genetic effects.
Exome-wide association study of plasma lipids in > 300,000 individuals
Dajiang J. Liu,Gina M. Peloso,Haojie Yu,Adam S. Butterworth,Xiao Wang,Anubha Mahajan,Danish Saleheen,Connor A. Emdin,Dewan S. Alam,Alexessander Couto Alves,Philippe Amouyel,Emanuele Di Angelantonio,Dominique Arveiler,Themistocles L. Assimes,Paul L. Auer,Usman Baber,Christie M. Ballantyne,Lia E. Bang,Marianne Benn,Joshua C. Bis,Michael Boehnke,Eric Boerwinkle,Jette Bork-Jensen,Erwin P. Bottinger,Ivan Brandslund,Morris J. Brown,Fabio Busonero,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Y. Eugene Chen,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,John M. C. Connell,Francesco Cucca,L. Adrienne Cupples,Scott M. Damrauer,Gail Davies,Ian J. Deary,George Dedoussis,Joshua C. Denny,Anna F. Dominiczak,Marie-Pierre Dubé,Tapani Ebeling,Gudny Eiriksdottir,Tõnu Esko,Aliki-Eleni Farmaki,Mary F. Feitosa,Marco M Ferrario,Jean Ferrières,Ian Ford,Myriam Fornage,Paul W. Franks,Timothy M. Frayling,Ruth Frikke-Schmidt,Lars G. Fritsche,Philippe M. Frossard,Valentin Fuster,Santhi K. Ganesh,Wei Gao,Melissa E. Garcia,Christian Gieger,Franco Giulianini,Mark O. Goodarzi,Harald Grallert,Niels Grarup,Leif Groop,Megan L. Grove,Vilmundur Gudnason,Torben Hansen,Tamara B. Harris,Caroline Hayward,Joel N. Hirschhorn,Oddgeir L. Holmen,Jennifer E. Huffman,Yong Huo,Kristian Hveem,Sehrish Jabeen,Anne U. Jackson,Johanna Jakobsdottir,Marjo-Riitta Järvelin,Gorm B. Jensen,Marit E. Jørgensen,J. Wouter Jukema,Johanne Marie Justesen,Pia R. Kamstrup,Stavroula Kanoni,Fredrik Karpe,Frank Kee,Amit Khera,Derek Klarin,Heikki A. Koistinen,Jaspal S. Kooner,Charles Kooperberg,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,Claudia Langenberg,Anne Langsted,Lenore J. Launer,Torsten Lauritzen,David C. Liewald,Li-An Lin,Allan Linneberg,Ruth J. F. Loos,Yingchang Lu,Xiangfeng Lu,Reedik Mägi,Anders Mälarstig,Ani Manichaikul,Alisa K. Manning,Pekka Mäntyselkä,Eirini Marouli,Nicholas G. D. Masca,Andrea Maschio,James B. Meigs,Olle Melander,Andres Metspalu,Andrew P. Morris,Alanna C. Morrison,Antonella Mulas,Martina Mueller-Nurasyid,Patricia B. Munroe,Matt Neville,Jonas B. Nielsen,Sune F. Nielsen,Børge G. Nordestgaard,Jose M. Ordovas,Roxana Mehran,C.J. O'Donnell,Marju Orho-Melander,Cliona Molony,Pieter Muntendam,Sandosh Padmanabhan,Colin N. A. Palmer,Dorota Pasko,Aniruddh P. Patel,Oluf Pedersen,Markus Perola,Annette Peters,Charlotta Pisinger,Giorgio Pistis,Ozren Polasek,Neil Poulter,Bruce M. Psaty,Daniel J. Rader,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Alexander P. Reiner,Frida Renström,Stephen S. Rich,Paul M. Ridker,John D. Rioux,Neil R. Robertson,Dan M. Roden,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Serena Sanna,Naveed Sattar,Ellen M. Schmidt,Robert A. Scott,Peter S. Sever,Raquel S. Sevilla,Christian M. Shaffer,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Albert V. Smith,Blair H. Smith,Sangeetha Somayajula,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kathleen Stirrups,Nathan O. Stitziel,Konstantin Strauch,Heather M. Stringham,Praveen Surendran,Hayato Tada,Alan R. Tall,Hua Tang,Jean-Claude Tardif,Kent D. Taylor,Stella Trompet,Philip S. Tsao,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Natalie R. van Zuydam,Anette Varbo,Tibor V. Varga,Jarmo Virtamo,Melanie Waldenberger,Nan Wang,Nicholas J. Wareham,Helen R. Warren,Peter Weeke,Joshua S. Weinstock,Jennifer Wessel,James G. Wilson,Peter W.F. Wilson,Ming Xu,Hanieh Yaghootkar,Robin Young,Eleftheria Zeggini,He Zhang,Neil S Zheng,Weihua Zhang,Yan Zhang,Wei Zhou,Yanhua Zhou,Magdalena Zoledziewska,Joanna M. M. Howson,John Danesh,Mark I. McCarthy,Chad A. Cowan,Gonçalo R. Abecasis,Panos Deloukas,Kiran Musunuru,Cristen J. Willer,Sekar Kathiresan +226 more
Journal ArticleDOI
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Yingchang Lu,Heather M. Highland,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Tõnu Esko,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Audrey E. Hendricks,Tugce Karaderi,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Nicholas G. D. Masca,Alisa K. Manning,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Alexander P. Reiner,Sailaja Vedantam,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Folkert W. Asselbergs,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,John Danesh,Gail Davies,Gail Davies,Paul I.W. de Bakker,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I. den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Fotios Drenos,Mengmeng Du,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Paul W. Franks,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Jörgen Grabe,Hans-Jörgen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Liang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Andrew C. Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Tellervo Korhonen,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Helena Kuivaniemi,Zoltán Kutalik,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken Sin Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,Markus Perola,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rb Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,Manuel A. Rivas,David J. Roberts,David J. Roberts,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne H-H Sheu,Wayne H-H Sheu,Xueling Sim,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Hayato Tada,Katherine E. Tansey,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Gerard Tromp,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Völker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Laura M. Yerges-Armstrong,Robin Young,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos +489 more
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Journal ArticleDOI
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Praveen Surendran,Fotios Drenos,Robin Young,Helen R. Warren,James P. Cook,Alisa K. Manning,Niels Grarup,Xueling Sim,Daniel R. Barnes,Kate Witkowska,James R Staley,Vinicius Tragante,Taru Tukiainen,Hanieh Yaghootkar,Nicholas Masca,Daniel F. Freitag,Teresa Ferreira,Olga Giannakopoulou,Andrew Tinker,Magdalena Harakalova,Evelin Mihailov,Chunyu Liu,Aldi T. Kraja,Sune F. Nielsen,Asif Rasheed,Maria Samuel,Wei Zhao,Lori L. Bonnycastle,Anne U. Jackson,Narisu Narisu,Amy J. Swift,Lorraine Southam,Jonathan Marten,Jeroen R. Huyghe,Alena Stančáková,Cristiano Fava,Therese Ohlsson,Angela Matchan,Kathleen Stirrups,Jette Bork-Jensen,Anette P. Gjesing,Jukka Kontto,Markus Perola,Susan Shaw-Hawkins,Aki S. Havulinna,He Zhang,Louise A. Donnelly,Christopher J. Groves,N. William Rayner,Matt Neville,Neil R. Robertson,Andrianos M. Yiorkas,Karl-Heinz Herzig,Eero Kajantie,Weihua Zhang,Sara M. Willems,Lars Lannfelt,Giovanni Malerba,Nicole Soranzo,Elisabetta Trabetti,Niek Verweij,Evangelos Evangelou,Alireza Moayyeri,Anne-Claire Vergnaud,Christopher P. Nelson,Alaitz Poveda,Tibor V. Varga,Muriel J. Caslake,Anton J. M. de Craen,Stella Trompet,Jian'an Luan,Robert A. Scott,Sarah E. Harris,David C. Liewald,Riccardo E. Marioni,Cristina Menni,Aliki-Eleni Farmaki,Göran Hallmans,Frida Renström,Jennifer E. Huffman,Maija Hassinen,Stephen Burgess,Ramachandran S. Vasan,Janine F. Felix,Maria Uria-Nickelsen,Anders Mälarstig,Dermot F. Reilly,Maarten Hoek,Thomas F. Vogt,Honghuang Lin,Wolfgang Lieb,Matthew Traylor,Hugh S. Markus,Heather M. Highland,Anne E. Justice,Eirini Marouli,Jaana Lindström,Matti Uusitupa,Pirjo Komulainen,Timo A. Lakka,Rainer Rauramaa,Ozren Polasek,Igor Rudan,Olov Rolandsson,Paul W. Franks,George Dedoussis,Tim D. Spector,Pekka Jousilahti,Satu Männistö,Ian J. Deary,John M. Starr,Claudia Langenberg,Nicholas J. Wareham,Morris Brown,Anna F. Dominiczak,John M. C. Connell,J. Wouter Jukema,Naveed Sattar,Ian Ford,Chris J. Packard,Tõnu Esko,Reedik Mägi,Andres Metspalu,Rudolf A. de Boer,Peter van der Meer,Pim van der Harst,Giovanni Gambaro,Erik Ingelsson,Lars Lind,Paul I.W. de Bakker,Mattijs E. Numans,Ivan Brandslund,Cramer Christensen,Eva Rabing Brix Petersen,Eeva Korpi-Hyövälti,Heikki Oksa,John C. Chambers,Jaspal S. Kooner,Alexandra I. F. Blakemore,Steve Franks,Marjo-Riitta Järvelin,Lise Lotte N. Husemoen,Allan Linneberg,Tea Skaaby,Betina H. Thuesen,Fredrik Karpe,Jaakko Tuomilehto,Alex S. F. Doney,Andrew D. Morris,Colin N. A. Palmer,Oddgeir L. Holmen,Kristian Hveem,Cristen J. Willer,Tiinamaija Tuomi,Leif Groop,Annemari Käräjämäki,Aarno Palotie,Samuli Ripatti,Veikko Salomaa,Dewan S. Alam,Abdulla Al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Mark I. McCarthy,Neil Poulter,Alice Stanton,Peter S. Sever,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Panos Deloukas,Paul Elliott,Eleftheria Zeggini,Sekar Kathiresan,Olle Melander,Johanna Kuusisto,Markku Laakso,Sandosh Padmanabhan,David J. Porteous,Caroline Hayward,Generation Scotland,Francis S. Collins,Karen L. Mohlke,Torben Hansen,Oluf Pedersen,Michael Boehnke,Heather M. Stringham,Philippe M. Frossard,Christopher Newton-Cheh,Martin D. Tobin,Børge G. Nordestgaard,Mark J. Caulfield,Anubha Mahajan,Andrew P. Morris,Maciej Tomaszewski,Nilesh J. Samani,Danish Saleheen,Folkert W. Asselbergs,Cecilia M. Lindgren,John Danesh,Louise V. Wain,Adam S. Butterworth,Joanna M. M. Howson,Patricia B. Munroe +209 more
TL;DR: Thirty new blood pressure– or hypertension-associated genetic regions in the general population are identified, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects than common variants.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
Folkert W. Asselbergs,Yiran Guo,Yiran Guo,Erik P A Van Iperen,Suthesh Sivapalaratnam,Vinicius Tragante,Matthew B. Lanktree,Leslie A. Lange,Berta Almoguera,Yolande Appelman,John Barnard,Jens Baumert,Amber L. Beitelshees,Tushar Bhangale,Yii-Der Ida Chen,Tom R. Gaunt,Yan Gong,Jemma C. Hopewell,Toby Johnson,Marcus E. Kleber,Taimour Y. Langaee,Mingyao Li,Yun Li,Kiang Liu,Caitrin W. McDonough,Matthijs F.L. Meijs,Rita P.S. Middelberg,Kiran Musunuru,Kiran Musunuru,Christopher P. Nelson,Jeffery R. O'Connell,Sandosh Padmanabhan,James S. Pankow,Nathan Pankratz,Suzanne Rafelt,Ramakrishnan Rajagopalan,Simon P. R. Romaine,Nicholas J. Schork,Jonathan A. Shaffer,Haiqing Shen,Erin N. Smith,Sam E. Tischfield,Peter J. van der Most,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Kelly A. Volcik,Li Zhang,Kent R. Bailey,Kristian M. Bailey,Florianne Bauer,Jolanda M. A. Boer,Peter S. Braund,Amber A. Burt,Paul Burton,Sarah G. Buxbaum,Wei Chen,Rhonda M. Cooper-DeHoff,L. Adrienne Cupples,L. Adrienne Cupples,Jonas S. Dejong,Christian Delles,David Duggan,Myriam Fornage,Clement E. Furlong,Nicole L. Glazer,John G. Gums,Claire E. Hastie,Michael V. Holmes,Thomas Illig,Susan Kirkland,Mika Kivimäki,Ronald Klein,Barbara E.K. Klein,Charles Kooperberg,Kandice Kottke-Marchant,Meena Kumari,Andrea Z. LaCroix,Laya Mallela,Gurunathan Murugesan,Jose M. Ordovas,Willem H. Ouwehand,Wendy S. Post,Richa Saxena,Richa Saxena,Hubert Scharnagl,Pamela J. Schreiner,Tina Shah,Denis C. Shields,Daichi Shimbo,Sathanur R. Srinivasan,Ronald P. Stolk,Daniel I. Swerdlow,Herman A. Taylor,Eric J. Topol,Elina Toskala,Joost L. Van Pelt,Jessica van Setten,Salim Yusuf,John C. Whittaker,John C. Whittaker,A. H. Zwinderman,Sonia S. Anand,Anthony J. Balmforth,Gerald S. Berenson,Connie R. Bezzina,Connie R. Bezzina,Bernhard O. Boehm,Eric Boerwinkle,Juan P. Casas,Juan P. Casas,Mark J. Caulfield,Robert Clarke,John M. C. Connell,Karen J. Cruickshanks,Karina W. Davidson,Ian N. M. Day,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Pieter A. Doevendans,Anna F. Dominiczak,Alistair S. Hall,Catharina A. Hartman,Christian Hengstenberg,Hans L. Hillege,Marten H. Hofker,Steve E. Humphries,Gail P. Jarvik,Julie A. Johnson,Bernhard M. Kaess,Sekar Kathiresan,Sekar Kathiresan,Wolfgang Koenig,Debbie A Lawlor,Winfried März,Winfried März,Olle Melander,Braxton D. Mitchell,Grant W. Montgomery,Patricia B. Munroe,Sarah S. Murray,Stephen Newhouse,N. Charlotte Onland-Moret,Neil R Poulter,Bruce M. Psaty,Bruce M. Psaty,Susan Redline,Stephen S. Rich,Jerome I. Rotter,Heribert Schunkert,Peter Sever,Alan R. Shuldiner,Alan R. Shuldiner,Roy L. Silverstein,Alice V. Stanton,Alice V. Stanton,Barbara Thorand,Mieke D. Trip,Michael Y. Tsai,Pim van der Harst,Ellen Van Der Schoot,Yvonne T. van der Schouw,W. M. Monique Verschuren,Hugh Watkins,Arthur A.M. Wilde,Bruce H. R. Wolffenbuttel,John Whitfield,G. Kees Hovingh,Christie M. Ballantyne,Cisca Wijmenga,Muredach P. Reilly,Nicholas G. Martin,James G. Wilson,Daniel J. Rader,Nilesh J. Samani,Nilesh J. Samani,Alexander P. Reiner,Robert A. Hegele,John J.P. Kastelein,Aroon D. Hingorani,Philippa J. Talmud,Hakon Hakonarson,Clara C. Elbers,Brendan J. Keating,Fotios Drenos +184 more
TL;DR: This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.