N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Functional variants of the angiotensinogen gene determine antihypertensive responses to angiotensin-converting enzyme inhibitors in subjects of African origin.
Angela J. Woodiwiss,Benedicta Nkeh,Nilesh J. Samani,Danelle Badenhorst,Muzi J. Maseko,Armindo D. Tiago,Geoffrey P. Candy,Elena Libhaber,Pinhas Sareli,Richard Brooksbank,Gavin R. Norton +10 more
TL;DR: Functional variants of the AGT gene contribute to the variability of antihypertensive responses to ACEI monotherapy in individuals of African ancestry, with genotype determining whether or not responses occur.
Journal ArticleDOI
QALYs in cost-effectiveness analysis: an overview for cardiologists
TL;DR: A selected set of cost-effectiveness analyses of recently introduced cardiovascular treatments are reviewed and an outcome measure that expresses the duration and quality of life, the quality-adjusted life year, is reviewed.
Journal ArticleDOI
Mitral valve repair for active culture positive infective endocarditis
George Doukas,Mehmet Oc,Christos Alexiou,Andrzej W. Sosnowski,Nilesh J. Samani,Tomasz J. Spyt +5 more
TL;DR: MV repair for active culture positive endocarditis is associated with low operative mortality and provides satisfactory freedom from recurrent infection, freedom from repeat operation, and survival.
Journal ArticleDOI
DNA Sequence Variation in ACVR1C Encoding the Activin-Receptor Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.
Connor A. Emdin,Amit Khera,Amit Khera,Krishna G. Aragam,Krishna G. Aragam,Mary E. Haas,Mary E. Haas,Mark Chaffin,Derek Klarin,Derek Klarin,Pradeep Natarajan,Pradeep Natarajan,Alexander G. Bick,Alexander G. Bick,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Akihiro Nomura,Akihiro Nomura,Diego Ardissino,James G. Wilson,Heribert Schunkert,Ruth McPherson,Hugh Watkins,Roberto Elosua,Matthew J. Bown,Nilesh J. Samani,Usman Baber,Jeanette Erdmann,Namrata Gupta,John Danesh,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan +33 more
TL;DR: Findings indicate that variants predicted to lead to loss of ACVR1C gene function influence body fat distribution and protect from type 2 diabetes.
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Louise V. Wain,Ahmad Vaez,Rick Jansen,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul F. O'Reilly,Claudia P. Cabrera,Helen R. Warren,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Tõnu Esko,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola Del Greco M,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Jonathan Marten,Ilaria Gandin,Sarah E. Harris,Tatijana Zemunik,Yingchang Lu,Evangelos Evangelou,Nabi Shah,Martin H. de Borst,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Michael R. Barnes,Chiara Batini,John Beilby,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Morris Brown,Marco Brumat,Harry Campbell,John C. Chambers,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Martin Farrall,Teresa Ferreira,Mattias Frånberg,He Gao,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Elizabeth G. Holliday,Jennie Hui,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Borbala Mifsud,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Sandosh Padmanabhan,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Neil Poulter,Peter P. Pramstaller,Olli T. Raitakari,Meixia Ren,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Marc A. Seelen,Denis C. Shields,David S. Siscovick,Rossella Sorice,Alice Stanton,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Simon Thom,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H. Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,John Attia,Peter S. Sever,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Pim van der Harst,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,Caroline Hayward,Jaspal S. Kooner,C M Lindgren,Veronique Vitart,Nilesh J. Samani,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Andres Metspalu,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Christopher Newton-Cheh,Patricia B. Munroe,Paul Elliott,Daniel I. Chasman,Aravinda Chakravarti,Joanne Knight,Andrew P. Morris,Daniel Levy,Martin D. Tobin,Harold Snieder,Mark J. Caulfield,Georg Ehret,T. Y. Alistair,J. P. Betholdson,Limin Xiao +245 more