N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Discovering patterns of pleiotropy in genome-wide association studies
J Zhana,Jv Setten,James P. Brody,Brenton R. Swenson,Anne M. Butler,Harry Campbell,Fabiola M Del Greco,Daniel S. Evans,Q Gibson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kathleen F. Kerr,Bouwe P. Krijthe,Leo-Pekka Lyytikäinen,Craig Muller,Martina Müller-Nurasyid,Ilja M. Nolte,Sandosh Padmanabhan,Ritchie,Antonietta Robino,Albert V. Smith,Maristella Steri,Toshiko Tanaka,Alexander Teumer,Stella Trompet,S. Ulivi,Niek Verweij,Xiaoyan Yin,Davíð O. Arnar,Davíð O. Arnar,Folkert W. Asselbergs,Folkert W. Asselbergs,John Barnard,J. C. Bis,Stefan Blankenberg,Eric Boerwinkle,Yuki Bradford,Brendan M. Buckley,Mina K. Chung,Diane M. Crawford,Hoed,Josh C. Denny,Anna F. Dominiczak,G. Ehret,Mark Eijgelsheim,Patrick T. Ellinor,Stephan B. Felix,Lude Franke,T.B. Harris,Susan R. Heckbert,Hilma Holm,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gandin Ilaria,Annamaria Iorio,Mika Kähönen,Ivana Kolcic,Jan A. Kors,Edward G. Lakatta,L. J. Launer,Honghuang Lin,Haonan Lin,Yongmei Liu,R. J. F. Loos,Steven A. Lubitz,Peter W. Macfarlane,Jared W. Magnani,Irene Mateo Leach,Thomas Meitinger,B. D. Mitchell,Thomas Münzel,George J. Papanicolaou,Annette Peters,A. Pfeufer,PM Pramstaller,Olli T. Raitakari,Jerome I. Rotter,Igor Rudan,Nilesh J. Samani,David Schlessinger,CT Aldana Silva,Moritz F. Sinner,Jonathan D. Smith,Harold Snieder,Elsayed Z. Soliman,Tim D. Spector,David J. Stott,Konstantin Strauch,Kirill V. Tarasov,A.G. Uitterlinden,Wagoner van,Uwe Völker,Henry Völzke,M. Waldenberger,Harm-Jan Westra,Philipp S. Wild,Tanja Zeller,Alvaro Alonso,Christy L. Avery,Stefania Bandinelli,E J Benjamin,Francesco Cucca,Steven R. Cummings,Marcus Dörr,L Ferrucci,Paolo Gasparini,Vilmundar Gudnason,Caroline Hayward,Andrew A. Hicks,Yalda Jamshidi,Joop Jukema,Stefan Kääb,Terho Lehtimäki,Patricia B. Munroe,Afshin Parsa,O Polasekd,Bruce M. Psaty,Dan M. Roden,Renate B. Schnabel,Gianfranco Sinagra,Kari Stefansson,Kari Stefansson,Bruno H. Stricker,Pv Harst der,CM Duijn van,James F. Wilson,Sina A. Gharib,Pi Bakker de,A Isaacs,Dan E. Arking,N. Sotoodehnia,JS Baderab +131 more
TL;DR: Two methods based on a Bayesian framework, SNP And Pleiotropic PHenotype Organization (SAPPHO) and the other incorporating a full phenotype covariance structure are introduced, which learn patterns of pleiotropy from genotype and phenotype data, using identified associations to discover additional associations with shared patterns.
Journal ArticleDOI
Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis
Teresa Trenkwalder,Christopher P. Nelson,Muntaser D. Musameh,Ify R. Mordi,Thorsten Kessler,Costanza Pellegrini,Radoslaw Debiec,Tobias Rheude,Viktor Lazovic,Lingyao Zeng,Andreas Martinsson,J. Gustav Smith,Jesper R. Gådin,Anders Franco-Cereceda,Per Eriksson,Jonas B. Nielsen,Sarah E. Graham,Cristen J. Willer,Kristian Hveem,Adnan Kastrati,Peter S. Braund,Colin N. A. Palmer,Amparo Aracil,Oliver Husser,Wolfgang Koenig,Heribert Schunkert,Chim C. Lang,Christian Hengstenberg,Christian Hengstenberg,Nilesh J. Samani +29 more
TL;DR: This study confirms the association of the LPA locus with risk of AVS, with a higher effect in those without concomitant CAD, and concludes that 9p21 was not associated with AVS.
Journal ArticleDOI
Reproducibility of telomere length assessment: Authors’ response to Damjan Krstajic and Ljubomir Buturovic
Carmen Martin-Ruiz,Duncan M. Baird,Laureline Roger,Petra Boukamp,Damir Krunic,Richard M. Cawthon,Martin M Dokter,Pim van der Harst,Sofie Bekaert,Tim De Meyer,Göran Roos,Ulrika Svenson,Veryan Codd,Nilesh J. Samani,Liane M. McGlynn,Paul G. Shiels,Karen A. Pooley,Alison M. Dunning,Rachel Cooper,Andrew Wong,Andrew Kingston,Thomas von Zglinicki +21 more
TL;DR: Reproducibility of telomere length assessment : Authors' Response to Damjan Krstajic and Ljubomir Buturovic.
Journal ArticleDOI
Is Southern blotting necessary to measure telomere length reproducibly? Authors’ Response to: Commentary: The reliability of telomere length measurements
Carmen Martin-Ruiz,Duncan M. Baird,Laureline Roger,Petra Boukamp,Damir Krunic,Richard M. Cawthon,Martin M Dokter,Pim van der Harst,Sofie Bekaert,Tim De Meyer,Göran Roos,Ulrika Svenson,Veryan Codd,Nilesh J. Samani,Liane M. McGlynn,Paul G. Shiels,Karen A. Pooley,Alison M. Dunning,Rachel Cooper,Andrew Wong,Andrew Kingston,Thomas von Zglinicki +21 more
TL;DR: Is Southern blotting necessary to measure telomere length reproducibly?
Journal ArticleDOI
When should we diagnose incomplete right bundle branch block
TL;DR: An rSr' pattern with QRS duration of less than 0.12 s in the right precordial leads can be due to incomplete right bundle branch block or can be a normal electrophysiological variant, to identify other ECG features that may help to distinguish between these two possibilities.