N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization.
Khaled Alfakih,B. Brown,R.A. Lawrance,Philip Warburton,Azhar Maqbool,Kevin Walters,Nilesh J. Samani,Stephen G. Ball,Anthony J. Balmforth,Alistair S. Hall +9 more
TL;DR: Evidence of association between the X-linked AT2 (-1332 G/A) polymorphism and premature CAD is observed with further evidence of a statistically significant association with stenotic atherosclerosis requiring revascularization.
Journal ArticleDOI
Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte Stress 1 gene promoter
TL;DR: This is the first study to demonstrate a direct link between MyoD activity and SRF transcriptional signalling, with clear implications for the understanding of muscle determination, differentiation and regeneration.
Journal ArticleDOI
Analysis of the renin gene intron A tandem repeat region of Milan and Lyon hypertensive rat strains.
Nilesh J. Samani,Madeleine Vincent,Jean Sassard,Ian W. Henderson,Michael A. Kaiser,William J. Brammar,John D. Swales +6 more
TL;DR: An analysis of Sprague-Dawley rats showed that at least three different renin gene alleles, two with Bgl II fragments of the same size as those seen in the Lyon strains, are randomly segregating in this population.
Journal ArticleDOI
Expanding the Concept of Telomere Dysfunction in Cardiovascular Disease
TL;DR: Most of the studies to date have used white blood cell telomere length as a marker of ageing, but these might not necessarily be the most relevant cells to study, and the association between telomeres length and the cardiovascular disease continuum may lie.
Journal ArticleDOI
Supplementary Material 1
Joshua C. Randall,Thomas W. Winkler,Zoltán Kutalik,Sonja I. Berndt,Anne U. Jackson,Keri L. Monda,Tuomas O. Kilpeläinen,Tõnu Esko,Reedik Mägi,Shengxu Li,Tsegaselassie Workalemahu,Mary F. Feitosa,Damien C. Croteau Chonka,Felix R. Day,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Adam E. Locke,Iain Mathieson,André Scherag,Sailaja Vedantam,Andrew R. Wood,Liming Liang,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Emmanouil T. Dermitzakis,Antigone S. Dimas,Fredrik Karpe,Josine L. Min,George Nicholson,Deborah J. Clegg,Thomas N. Person,Jon P. Krohn,Sabrina Bauer,Christa Buechler,Kristina Eisinger,Amélie Bonnefond,Philippe Froguel,Jouke-Jan Hottenga,Inga Prokopenko,Lindsay L. Waite,Tamara B. Harris,Albert V. Smith,Alan R. Shuldiner,Wendy L. McArdle,Mark J. Caulfield,Patricia B. Munroe,Henrik Grönberg,Yii-Der Ida Chen,Guo Li,Jacques S. Beckmann,Toby Johnson,Unnur Thorsteinsdottir,Maris Teder-Laving,Kay-Tee Khaw,Nicholas J. Wareham,Jing Hua Zhao,Najaf Amin,Ben A. Oostra,Aldi T. Kraja,Michael A. Province,L. Adrienne Cupples,Nancy L. Heard Costa,Jaakko Kaprio,Samuli Ripatti,Ida Surakka,Francis S. Collins,Jouko Saramies,Jaakko Tuomilehto,Antti Jula,Veikko Salomaa,Jeanette Erdmann,Christian Hengstenberg,Christina Loley,Heribert Schunkert,Claudia Lamina,H.-Erich Wichmann,Eva Albrecht,Christian Gieger,Andrew A. Hicks,Åsa Johansson,Peter P. Pramstaller,Sekar Kathiresan,Elizabeth K. Speliotes,Brenda W.J.H. Penninx,Anna-Liisa Hartikainen,Marjo-Riitta Järvelin,Ulf Gyllensten,Dorret I. Boomsma,Harry Campbell,James F. Wilson,Stephen J. Chanock,Martin Farrall,Anuj Goel,Carolina Medina-Gomez,Fernando Rivadeneira,Karol Estrada,André G. Uitterlinden,Albert Hofman,M. Carola Zillikens,Martin den Heijer,Lambertus A. Kiemeney,Andrea Maschio,Per Hall,Jonathan Tyrer,Alexander Teumer,Henry Völzke,Peter Kovacs,Anke Tönjes,Massimo Mangino,Tim D. Spector,Caroline Hayward,Igor Rudan,Alistair S. Hall,Nilesh J. Samani,Antony P. Attwood,Jennifer G. Sambrook,Joseph Hung,Lyle J. Palmer,Marja-Liisa Lokki,Juha Sinisalo,Gabrielle Boucher,Heikki V. Huikuri,Mattias Lorentzon,Claes Ohlsson,Niina Eklund,Johan G. Eriksson,Cristina Barlassina,Carlo Rivolta,Ilja M. Nolte,Harold Snieder,Melanie M. van der Klauw,Jana V. Van Vliet Ostaptchouk,Pablo V. Gejman,Jianxin Shi,Kevin B. Jacobs,Zhaoming Wang,Stephan J. L. Bakker,Irene Mateo Leach,Gerjan Navis,Pim van der Harst,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Jian Yang,Daniel I. Chasman,Paul M. Ridker,Lynda M. Rose,Terho Lehtimäki,Olli T. Raitakari,Devin Absher,Carlos Iribarren,Hanneke Basart,Kees Hovingh,Elina Hyppönen,Chris Power,Denise Anderson,John Beilby,Jennie Hui,Jennifer Jolley,Hendrik B. Sager,Stefan R. Bornstein,Peter Schwarz,Kati Kristiansson,Markus Perola,Jaana Lindström,Amy J. Swift,Matti Uusitupa,Mustafa Atalay,Timo A. Lakka,Rainer Rauramaa,Jennifer L. Bolton,Gerry Fowkes,Ross M. Fraser,Jackie F. Price,Krista Fischer,Kaarel KrjutÅ¡kov,Andres Metspalu,Evelin Mihailov,Claudia Langenberg,Jian'an Luan,Ken K. Ong,Peter S. Chines,Sirkka M. Keinanen Kiukaanniemi,Timo Saaristo,Sarah Edkins,Paul W. Franks,Göran Hallmans,Dmitry Shungin,Andrew D. Morris,Colin N. A. Palmer,Raimund Erbel,Susanne Moebus,Markus M. Nöthen,Sonali Pechlivanis,Kristian Hveem,Narisu Narisu,Anders Hamsten,Steve E. Humphries,Rona J. Strawbridge,Elena Tremoli,Harald Grallert,Barbara Thorand,Thomas Illig,Wolfgang Koenig,Martina Müller-Nurasyid,Annette Peters,Bernhard O. Boehm,Marcus E. Kleber,Winfried März,Bernhard R. Winkelmann,Johanna Kuusisto,Markku Laakso,Dominique Arveiler,Giancarlo Cesana,Kari Kuulasmaa,Jarmo Virtamo,John Yarnell,Diana Kuh,Andrew Wong,Lars Lind,Ulf de Faire,Bruna Gigante,Patrik K. E. Magnusson,Nancy L. Pedersen,George Dedoussis,Maria Dimitriou,Genovefa Kolovou,Stavroula Kanoni,Kathleen Stirrups,Lori L. Bonnycastle,Inger Njølstad,Tom Wilsgaard,Andrea Ganna,Emil Rehnberg,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Erik Ingelsson,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,David Schlessinger,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Mark I. McCarthy,Joel N. Hirschhorn,Lu Qi,Ruth J. F. Loos,Cecilia M. Lindgren,Kari E. North,Iris M. Heid +263 more
TL;DR: The member databases themselves produce regular releases, and for TIGRFAMs the number of models has increased from 1109 in release 1.0 to 1415 in release 2.0 (beginning of 2002).