N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts.
Maria Hughes,Olli Saarela,Jan Stritzke,Frank Kee,Kaisa Silander,Kaisa Silander,Norman Klopp,Jukka Kontto,Juha Karvanen,Christina Willenborg,Veikko Salomaa,Jarmo Virtamo,P. Amouyel,Dominique Arveiler,Jean Ferrières,Per-Gunner Wiklund,Jens Baumert,B Thorand,Patrick Diemert,David-Alexandre Trégouët,Christian Hengstenberg,Annette Peters,Alun Evans,Wolfgang Koenig,Jeanette Erdmann,Nilesh J. Samani,Kari Kuulasmaa,Heribert Schunkert +27 more
TL;DR: Genetic risk scores add precision to risk estimates for CHD and improve prediction beyond classic risk factors, particularly for middle aged men.
Journal ArticleDOI
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Yun J. Sung,Thomas W. Winkler,Lisa de las Fuentes,Amy R. Bentley,Michael R. Brown,Aldi T. Kraja,Karen Schwander,Ioanna Ntalla,Xiuqing Guo,Nora Franceschini,Yingchang Lu,Ching-Yu Cheng,Xueling Sim,Dina Vojinovic,Jonathan Marten,Solomon K. Musani,Changwei Li,Mary F. Feitosa,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Melissa A. Richard,Raymond Noordam,Stella Aslibekyan,Hugues Aschard,Hugues Aschard,Traci M. Bartz,Rajkumar Dorajoo,Yongmei Liu,Alisa K. Manning,Alisa K. Manning,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Bamidele O. Tayo,Helen R. Warren,Wei Zhao,Yanhua Zhou,Nana Matoba,Tamar Sofer,Maris Alver,Marzyeh Amini,Mathilde Boissel,Jin-Fang Chai,Xu Chen,Jasmin Divers,Ilaria Gandin,Chuan Gao,Franco Giulianini,Anuj Goel,Sarah E. Harris,Fernando Pires Hartwig,Andrea R. V. R. Horimoto,Fang-Chi Hsu,Anne U. Jackson,Mika Kähönen,Anuradhani Kasturiratne,Brigitte Kühnel,Karin Leander,Wen-Jane Lee,Keng-Hung Lin,Jian'an Luan,Colin A. McKenzie,He Meian,Christopher P. Nelson,Christopher P. Nelson,Rainer Rauramaa,Nicole Schupf,Robert A. Scott,Wayne Huey-Herng Sheu,Alena Stančáková,Fumihiko Takeuchi,Peter J. van der Most,Tibor V. Varga,Heming Wang,Yajuan Wang,Erin B. Ware,Stefan Weiss,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Saima Afaq,Tamuno Alfred,Najaf Amin,Dan E. Arking,Tin Aung,R. Graham Barr,Lawrence F. Bielak,Eric Boerwinkle,Eric Boerwinkle,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Jennifer A. Brody,Ulrich Broeckel,Claudia P. Cabrera,Brian E. Cade,Yu Caizheng,Archie Campbell,Mickaël Canouil,Aravinda Chakravarti,Ganesh Chauhan,Kaare Christensen,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Renée de Mutsert,H. Janaka de Silva,Stéphanie Debette,Stéphanie Debette,Marcus Dörr,Qing Duan,Charles B. Eaton,Georg Ehret,Georg Ehret,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Virginia Fisher,Nita G. Forouhi,Oscar H. Franco,Yechiel Friedlander,He Gao,Bruna Gigante,Misa Graff,C. Charles Gu,Dongfeng Gu,Preeti Gupta,Saskia P. Hagenaars,Tamara B. Harris,Jiang He,Sami Heikkinen,Chew-Kiat Heng,Chew-Kiat Heng,Makoto Hirata,Albert Hofman,Barbara V. Howard,Barbara V. Howard,Steven C. Hunt,Steven C. Hunt,Marguerite R. Irvin,Yucheng Jia,Roby Joehanes,Anne E. Justice,Tomohiro Katsuya,Joel D. Kaufman,Nicola D. Kerrison,Chiea Chuen Khor,Chiea Chuen Khor,Woon-Puay Koh,Heikki A. Koistinen,Heikki A. Koistinen,Pirjo Komulainen,Charles Kooperberg,José Eduardo Krieger,Michiaki Kubo,Johanna Kuusisto,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Benjamin Lehne,Cora E. Lewis,Yize Li,Sing Hui Lim,Shiow Lin,Ching-Ti Liu,Jianjun Liu,Jianjun Liu,Jingmin Liu,Kiang Liu,Y Liu,Marie Loh,Marie Loh,Kurt Lohman,Jirong Long,Tin Louie,Reedik Mägi,Anubha Mahajan,Thomas Meitinger,Andres Metspalu,Lili Milani,Yukihide Momozawa,Andrew P. Morris,Andrew P. Morris,Thomas H. Mosley,Peter J. Munson,Alison D. Murray,Mike A. Nalls,Ubaydah Nasri,Jill M. Norris,Kari E. North,Adesola Ogunniyi,Sandosh Padmanabhan,Walter Palmas,Nicholette D. Palmer,James S. Pankow,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Ozren Polasek,Olli T. Raitakari,Olli T. Raitakari,Frida Renström,Frida Renström,Treva Rice,Paul M. Ridker,Antonietta Robino,Jennifer G. Robinson,Lynda M. Rose,Igor Rudan,Charumathi Sabanayagam,Babatunde L. Salako,Kevin Sandow,Carsten Oliver Schmidt,Pamela J. Schreiner,William R. Scott,William R. Scott,Sudha Seshadri,Peter S. Sever,Colleen M. Sitlani,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Hua Tang,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,André G. Uitterlinden,Melanie Waldenberger,Lihua Wang,Ya X. Wang,Wen Bin Wei,Christine Williams,Gregory P. Wilson,Mary K. Wojczynski,Jie Yao,Jian-Min Yuan,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,John C. Chambers,John C. Chambers,Yii-Der Ida Chen,Ulf de Faire,Ian J. Deary,Tõnu Esko,Tõnu Esko,Martin Farrall,Terrence Forrester,Paul W. Franks,Paul W. Franks,Paul W. Franks,Barry I. Freedman,Philippe Froguel,Philippe Froguel,Paolo Gasparini,Paolo Gasparini,Christian Gieger,Bernardo L. Horta,Yi-Jen Hung,Jost B. Jonas,Jost B. Jonas,Norihiro Kato,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Terho Lehtimäki,Kae-Woei Liang,Kae-Woei Liang,Patrik K. E. Magnusson,Anne B. Newman,Albertine J. Oldehinkel,Alexandre C. Pereira,Alexandre C. Pereira,Susan Redline,Rainer Rettig,Nilesh J. Samani,Nilesh J. Samani,James Scott,Xiao-Ou Shu,Pim van der Harst,Lynne E. Wagenknecht,Nicholas J. Wareham,Hugh Watkins,David R. Weir,Ananda R. Wickremasinghe,Tangchun Wu,Wei Zheng,Yoichiro Kamatani,Cathy C. Laurie,Claude Bouchard,Richard S. Cooper,Michele K. Evans,Vilmundur Gudnason,Sharon L.R. Kardia,Stephen B. Kritchevsky,Daniel Levy,Jeffrey R. O'Connell,Bruce M. Psaty,Bruce M. Psaty,Rob M. van Dam,Mario Sims,Donna K. Arnett,Dennis O. Mook-Kanamori,Tanika N. Kelly,Ervin R. Fox,Caroline Hayward,Myriam Fornage,Charles N. Rotimi,Michael A. Province,Cornelia M. van Duijn,E. Shyong Tai,Tien Yin Wong,Ruth J. F. Loos,Alexander P. Reiner,Jerome I. Rotter,Xiaofeng Zhu,Laura J. Bierut,W. James Gauderman,Mark J. Caulfield,Paul Elliott,Kenneth Rice,Patricia B. Munroe,Alanna C. Morrison,L. Adrienne Cupples,Dabeeru C. Rao,Daniel I. Chasman +329 more
TL;DR: The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits and highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function.
Journal ArticleDOI
A saturated map of common genetic variants associated with human height
Loic Yengo,Sailaja Vedantam,Eirini Marouli,Julia Sidorenko,Eric Bartell,Saori Sakaue,Marielisa Graff,Anders U. Eliasen,Yunxuan Jiang,Sridharan Raghavan,Jenkai Miao,Joshua Daniel Arias,Ronen E. Mukamel,Cassandra N. Spracklen,Xianyong Yin,Shyh-Huei Chen,Teresa Ferreira,JI Yingjie,Kreete Lüll,Kuang Lin,Deborah E. Malden,Carolina Medina-Gomez,Moara Machado,Amy Moore,Sina Rüeger,Tarunveer S. Ahluwalia,Masato Akiyama,Matthew A. Allison,Marcus Alvarez,Mette K. Andersen,Alireza Ani,Vivek Appadurai,Liubov Arbeeva,Seema Bhaskar,Lawrence F. Bielak,Sailalitha Bollepalli,Lori L. Bonnycastle,Jette Bork-Jensen,Jonathan P. Bradfield,Yuki Bradford,Peter S. Braund,Jennifer A. Brody,Kristoffer Sølvsten Burgdorf,Brian E. Cade,Hui Cai,Qiuyin Cai,Archie Campbell,Marisa Cañadas-Garre,Eulalia Catamo,Jin-Fang Chai,Xiaoran Chai,Li Chang,Yipeng Chang,Chien-Hsiun Chen,Alessandra Chesi,Seung Hoan Choi,Ren-Hua Chung,Massimiliano Cocca,Maria Pina Concas,Christian Couture,Gabriel Cuellar-Partida,Rebecca D Danning,E. Warwick Daw,Frauke Degenhard,Graciela E. Delgado,Alessandro P Delitala,Ayse Demirkan,Xuan Deng,Poornima Devineni,Alexander Dietl,Maria Dimitriou,Latchezar Dimitrov,Rajkumar Dorajoo,Arif B. Ekici,Jorgen Engmann,Zammy Fairhurst-Hunter,Aliki-Eleni Farmaki,Jessica D. Faul,Juan Carlos Fernández-López,Lukas Forer,Margherita Francescatto,Sandra Freitag-Wolf,Christian Fuchsberger,Tessel E. Galesloot,Yan Gao,Zishan Gao,Frank Geller,Olga Giannakopoulou,Franco Giulianini,Anette P. Gjesing,Anuj Goel,Scott D. Gordon,Mathias Gorski,Sarah E. Graham,Jakob Grove,Xiuqing Guo,Stefan Gustafsson,Jeffrey Haessler,Thomas Hansen,Aki S. Havulinna,Simon Haworth,Jiang He,Nancy L. Heard-Costa,Prashantha Hebbar,George Hindy,Yuk-Lam Ho,Edith Hofer,Elizabeth G. Holliday,Katrin Horn,Whitney E. Hornsby,Jouke-Jan Hottenga,Hongyan Huang,Jie Huang,Alicia Huerta-Chagoya,Jennifer E. Huffman,Yi Jen Hung,Shaofeng Huo,Mi Yeong Hwang,H. Iha,Daisuke Ikeda,Masato Isono,Anne U. Jackson,Susanne Jäger,Iris E. Jansen,Ingegerd Johansson,Jost B. Jonas,Anna Jonsson,Torben Jørgensen,Ioanna P. Kalafati,Masahiro Kanai,Stavroula Kanoni,Line Lund Kårhus,Anuradhani Kasturiratne,Tomohiro Katsuya,Takahisa Kawaguchi,Rachel L. Kember,Katherine A. Kentistou,Han Na Kim,Young-Jin Kim,Marcus E. Kleber,Maria J. Knol,Azra Kurbasic,Marie Lauzon,Phuong Le,Rod A. Lea,Jong-Young Lee,Hampton L. Leonard,Shengchao A. Li,Xiaohui Li,Xiaoyin Li,Jin Liang,Honghuang Lin,Shih-Yi Lin,Jun Liu,Xueping Liu,Ken Sin Lo,Jirong Long,Laura Lorés-Motta,Jian'an Luan,Valeriya Lyssenko,Leo-Pekka Lyytikäinen,Anubha Mahajan,Vasiliki Mamakou,Massimo Mangino,Ani Manichaikul,Jonathan Marten,Manuel Mattheisen,L. Mavarani,Aaron McDaid,Karina Meidtner,Tori L. Melendez,Josep M. Mercader,Yuri Milaneschi,Jason E. Miller,Iona Y. Millwood,Pashupati P. Mishra,Ruth Mitchell,Line Tang Møllehave,Anna Morgan,Soeren Mucha,Matthias Munz,Masahiro Nakatochi,Christopher P. Nelson,Maria Nethander,Chu Won Nho,Aneta Aleksandra Nielsen,Ilja M. Nolte,Suraj S. Nongmaithem,Raymond Noordam,Ioanna Ntalla,Teresa Nutile,Anita Pandit,Paraskevi Christofidou,Katri Pärna,Marc Pauper,Eva R. B. Petersen,Liselotte Petersen,Niina Pitkänen,Ozren Polasek,Alaitz Poveda,Michael Preuss,Saiju Pyarajan,Laura M. Raffield,Hiromi Rakugi,Julia Ramirez,Asif Rasheed,Dennis Raven,Nigel W. Rayner,Carlos Riveros,Rebecca Rohde,Daniela Ruggiero,Sanni Ruotsalainen,Kathleen A. Ryan,Maria Sabater-Lleal,Richa Saxena,Markus Scholz,Anoop K. Sendamarai,Botong Shen,Jingchunzi Shi,Jae Hun Shin,Carlo Sidore,Xueling Sim,Colleen M. Sitlani,Roderick C. Slieker,Roelof A.J. Smit,Jennifer A. Smith,Laura Smyth,Lorraine Southam,Valgerdur Steinthorsdottir,Liangdan Sun,Fumihiko Takeuchi,Divya Sri Priyanka Tallapragada,Kent D. Taylor,Bamidele O. Tayo,Catherine Tcheandjieu,Natalie Terzikhan,Paola Tesolin,Alexander Teumer,Elizabeth Theusch,Deborah J. Thompson,Gudmar Thorleifsson,Paul R. H. J. Timmers,Stella Trompet,Constance Turman,Simona Vaccargiu,Sander W. van der Laan,Peter J. van der Most,Jan B. van Klinken,Jessica van Setten,Shefali S. Verma,Niek Verweij,Yogasudha Veturi,Carol A. Wang,Chaolong Wang,Lihua Wang,Zhe Wang,Helen R. Warren,Wenjie Wei,Ananda R. Wickremasinghe,Matthias Wielscher,Kerri L. Wiggins,Bendik S. Winsvold,Andrew Wong,Yang Wu,Matthias Wuttke,Rong Xi,Tian Xie,Ken Yamamoto,Jingyun Yang,Jie Yao,Hannah Young,Noha A. Yousri,Lingyao Zeng,Weihua Zhang,Xinyuan Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhou,Martina E. Zimmermann,Magdalena Zoledziewska,Linda S. Adair,Hieab H.H. Adams,Carlos A. Aguilar-Salinas,Fahd Al-Mulla,Donna K. Arnett,Folkert W. Asselbergs,Bjørn Olav Åsvold,John Attia,Bernhard Banas,Stefania Bandinelli,David A. Bennett,Tobias Bergler,Dwaipayan Bharadwaj,Ginevra Biino,Hans Bisgaard,Eric Boerwinkle,Carsten A. Böger,Klaus Bønnelykke,Dorret I. Boomsma,Anders D. Børglum,Judith B. Borja,Claude Bouchard,Donald W. Bowden,Ivan Brandslund,Ben Michael Brumpton,Julie E. Buring,Mark J. Caulfield,John C. Chambers,Giriraj R. Chandak,Stephen J. Chanock,Nish Chaturvedi,Yii-Der Ida Chen,Zhengming Chen,Ching-Yu Cheng,Ingrid E. Christophersen,Marina Ciullo,John W. Cole,Francis S. Collins,Richard S. Cooper,Miguel Cruz,Francesco Cucca,L. Adrienne Cupples,Michael J. Cutler,Scott M. Damrauer,Thomas Meinertz Dantoft,Gert J. de Borst,Lisette C. P. G. M. de Groot,Philip L. De Jager,Dominique P.V. de Kleijn,H. Janaka de Silva,George Dedoussis,Anneke I. den Hollander,Shufa Du,Douglas F. Easton,Petra J. M. Elders,A. Heather Eliassen,Patrick T. Ellinor,Sölve Elmståhl,Jeanette Erdmann,Michele K. Evans,Diane Fatkin,Bjarke Feenstra,Mary F. Feitosa,Luigi Ferrucci,Ian Ford,Myriam Fornage,Andre Franke,Paul W. Franks,Barry I. Freedman,Paolo Gasparini,Christian Gieger,Giorgia Girotto,Michael E. Goddard,Yvonne M. Golightly,Clicerio González-Villalpando,Penny Gordon-Larsen,Harald Grallert,Struan F.A. Grant,Niels Grarup,Lyn R. Griffiths,Leif Groop,Vilmundur Gudnason,Christopher A. Haiman,Hakon Hakonarson,Torben Hansen,Catharina A. Hartman,Andrew T. Hattersley,Caroline Hayward,Susan R. Heckbert,Chew-Kiat Heng,Christian Hengstenberg,Alex W. Hewitt,Haretsugu Hishigaki,Carel B. Hoyng,Paul L. Huang,Wei Huang,Steven C. Hunt,Kristian Hveem,Elina Hyppönen,William G. Iacono,Sahoko Ichihara,M. Arfan Ikram,Carmen R. Isasi,Rebecca D. Jackson,Marjo-Ritta Jarvelin,Zidan Jin,Karl-Heinz Jöckel,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Mika Kähönen,Yoichiro Kamatani,Kui Dong Kang,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Norihiro Kato,Frank Kee,Thorsten Kessler,Amit Khera,Chiea Chuen Khor,Lambertus A. Kiemeney,Bong-Jo Kim,EunGyul Kim,Hyung Lae Kim,Paulus Kirchhof,M Kivimaki,Woon-Puay Koh,Heikki A. Koistinen,Genovefa Kolovou,Jaspal S. Kooner,Charles Kooperberg,Anna Köttgen,Peter Kovacs,Adriaan O. Kraaijeveld,Peter Kraft,R. Krauß,Meena Kumari,Zoltán Kutalik,Markku Laakso,Leslie A. Lange,Claudia Langenberg,Lenore J. Launer,Loic Le Marchand,Hye Jin Lee,Nanette R. Lee,Terho Lehtimäki,Huaixing Li,Liming Li,Wolfgang Liebig,Xu（林旭） Lin,Lars Lind,Allan Linneberg,Ching-Ti Liu,Jianjun Liu,Markus Loeffler,Barry London,Steven A. Lubitz,Stephen J. Lye,David A. Mackey,Reedik Mägi,Patrik K. E. Magnusson,Gregory M. Marcus,Pedro Marques Vidal,Nicholas G. Martin,Winfried März,Fumihiko Matsuda,Robert W. McGarrah,Matt McGue,Amy Jayne McKnight,Sarah E. Medland,Dan Mellström,Andres Metspalu,Braxton D. Mitchell,Paul Mitchell,Dennis O. Mook-Kanamori,Andrew D. Morris,Lorelei A. Mucci,Patricia B. Munroe,Mike A. Nalls,Saman Nazarian,Amanda E. Nelson,Matt Neville,Christopher Newton-Cheh,Christopher Sivert Nielsen,Markus M. Nöthen,Claes Ohlsson,Albertine J. Oldehinkel,Lorena Orozco,Katja Pahkala,Päivi Pajukanta,Colin N. A. Palmer,Esteban J. Parra,Cristian Pattaro,Oluf Pedersen,Craig E. Pennell,Brenda W.J.H. Penninx,Louis Pérusse,Annette Peters,Patricia A. Peyser,David J. Porteous,Danielle Posthuma,Chris Power,Peter P. Pramstaller,Michael A. Province,Qibin Qi,Jia Qu,Daniel J. Rader,Olli T. Raitakari,Sarju Ralhan,Loukianos S. Rallidis,Dabeeru C. Rao,Susan Redline,Dermot F. Reilly,Alexander P. Reiner,Sang Youl Rhee,Paul M. Ridker,Michiel Rienstra,Samuli Ripatti,Marylyn D. Ritchie,Dan M. Roden,Frits R. Rosendaal,Jerome I. Rotter,Igor Rudan,Femke Rutters,Charumathi Sabanayagam,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Dharambir K. Sanghera,Naveed Sattar,Börge Schmidt,E. E. Schmidt,Reinhold Schmidt,Matthias B. Schulze,Heribert Schunkert,Laura J. Scott,Rodney J. Scott,Peter S. Sever,Eric J. Shiroma,M. Benjamin Shoemaker,Xiao-Ou Shu,Eleanor M. Simonsick,Mario Sims,Jai Rup Singh,Andrew B. Singleton,Moritz F. Sinner,J. Gustav Smith,Harold Snieder,Tim D. Spector,Meir J. Stampfer,Klaus Stark,David P. Strachan,Leen M 't Hart,Yasuharu Tabara,Hua Tang,Jean-Claude Tardif,Thangavel Alphonse Thanaraj,Nicholas J. Timpson,Anke Tönjes,Angelo Tremblay,Tiinamaija Tuomi,Jaakko Tuomilehto,María Teresa Tusié-Luna,André G. Uitterlinden,Rob M. van Dam,P. Van der Harst,Nathalie van der Velde,Cornelia M. van Duijn,Natasja M. van Schoor,Veronique Vitart,Uwe Völker,Peter Vollenweider,Henry Völzke,Scott I. Vrieze,Niels Wacher-Rodarte,Mark Walker,Ya Xing Wang,Nicholas J. Wareham,Richard M. Watanabe,Hugh Watkins,David R. Weir,Thomas Werge,Elisabeth Widen,Lynne R. Wilkens,Gonneke Willemsen,Walter C. Willett,James F. Wilson,Tien Yin Wong,Jeong Taek Woo,Alan F. Wright,Jer-Yuarn Wu,Huichun Xu,Chittaranjan S. Yajnik,Mitsuhiro Yokota,Jian-Min Yuan,Eleftheria Zeggini,Babette S. Zemel,Wei Zheng,Xiaofeng Zhu,Joseph M. Zmuda,Alan B. Zonderman,John-Anker Zwart,Daniel I. Chasman,Yoon Shin Cho,Iris M. Heid,Mark I. McCarthy,Maggie C.Y. Ng,Christopher J. O'Donnell,Fernando Rivadeneira,Unnur Thorsteinsdottir,Yan V. Sun,E. Shyong Tai,Michael Boehnke,Panos Deloukas,Anne E. Justice,Cecilia M. Lindgren,Ruth J. F. Loos,Karen L. Mohlke,Kari E. North,Kari Stefansson,Robin G. Walters,Thomas W. Winkler,Kristin L. Young,Po-ru Loh,Tõnu Esko,Themistocles L. Assimes,Adam Auton,Gonçalo R. Abecasis,Cristen J. Willer,Adam E. Locke,Sonja I. Berndt,Guillaume Lettre,Timothy M. Frayling,Yukinori Okada,Andrew R. Wood,Peter M. Visscher,Joel N. Hirschhorn +617 more
TL;DR: In this article , the authors show that common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes.
Journal ArticleDOI
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Maria Teresa Landi,D. Timothy Bishop,Stuart MacGregor,Mitchell J. Machiela,Alexander J. Stratigos,Paola Ghiorzo,Myriam Brossard,Donato Calista,Jiyeon Choi,Maria Concetta Fargnoli,Tongwu Zhang,Monica Rodolfo,Adam J. Trower,Chiara Menin,Jacobo Martinez,Andreas Hadjisavvas,Lei Song,I. Stefanaki,Richard A. Scolyer,Rose Yang,Alisa M. Goldstein,Miriam Potrony,Katerina P. Kypreou,Lorenza Pastorino,Paola Queirolo,Cristina Pellegrini,Laura Cattaneo,Matthew Zawistowski,Pol Gimenez-Xavier,Arantxa Rodriguez,Lisa Elefanti,Siranoush Manoukian,Licia Rivoltini,Blair H. Smith,Maria A. Loizidou,Laura Del Regno,Daniela Massi,Mario Mandalà,Kiarash Khosrotehrani,Kiarash Khosrotehrani,Lars A. Akslen,Lars A. Akslen,Christopher I. Amos,Per Arne Andresen,Marie-Françoise Avril,Esther Azizi,H. Peter Soyer,H. Peter Soyer,Veronique Bataille,Veronique Bataille,Bruna Dalmasso,Lisa Bowdler,Kathryn P. Burdon,Wei V. Chen,Veryan Codd,Veryan Codd,Jamie E Craig,Tadeusz Dębniak,Mario Falchi,Mario Falchi,Shenying Fang,Eitan Friedman,Sarah Simi,Pilar Galan,Zaida García-Casado,Elizabeth M. Gillanders,Scott D. Gordon,Adèle C. Green,Adèle C. Green,Nelleke A. Gruis,Johan Hansson,Mark Harland,Jessica Harris,Per Helsing,Anjali K. Henders,Marko Hočevar,Veronica Höiom,David G. Hunter,David G. Hunter,Christian Ingvar,Rajesh Kumar,Julie Lang,G. Mark Lathrop,Jeffrey E. Lee,Xin Li,Jan Lubinski,Rona M. MacKie,M. Malt,Josep Malvehy,Kerrie McAloney,Hamida Mohamdi,Anders Molven,Anders Molven,Eric K. Moses,Rachel E. Neale,Srdjan Novaković,Dale R. Nyholt,Dale R. Nyholt,Håkan Olsson,Nick Orr,Lars G. Fritsche,Joan Anton Puig-Butille,Abrar A. Qureshi,Graham L. Radford-Smith,Graham L. Radford-Smith,Graham L. Radford-Smith,Juliette Randerson-Moor,Celia Requena,Casey Rowe,Nilesh J. Samani,Nilesh J. Samani,Marianna Sanna,Marianna Sanna,Dirk Schadendorf,Hans-Joachim Schulze,Lisa A. Simms,Mark Smithers,Fengju Song,Anthony J. Swerdlow,Nienke van der Stoep,Nicole A Kukutsch,Alessia Visconti,Alessia Visconti,Leanne Wallace,Sarah V. Ward,Sarah V. Ward,Lawrie Wheeler,Richard A. Sturm,Amy Hutchinson,Amy Hutchinson,Kristine Jones,Kristine Jones,Michael Malasky,Michael Malasky,Aurelie Vogt,Aurelie Vogt,Weiyin Zhou,Weiyin Zhou,Karen A. Pooley,David E. Elder,Jiali Han,Belynda Hicks,Belynda Hicks,Nicholas K. Hayward,Peter A. Kanetsky,Chad M. Brummett,Grant W. Montgomery,Catherine M. Olsen,Caroline Hayward,Alison M. Dunning,Nicholas G. Martin,Evangelos Evangelou,Evangelos Evangelou,Graham J. Mann,Graham J. Mann,Georgina V. Long,Georgina V. Long,Paul D.P. Pharoah,Douglas F. Easton,Jennifer H. Barrett,Anne E. Cust,Gonçalo R. Abecasis,David L. Duffy,David L. Duffy,David C. Whiteman,Helen Gogas,Arcangela De Nicolo,Margaret A. Tucker,Julia Newton-Bishop,Ketty Peris,Stephen J. Chanock,Florence Demenais,Kevin M. Brown,Susana Puig,Eduardo Nagore,Jianxin Shi,Mark M. Iles,Matthew Law,Q-Mega,Qtwin Investigators,andMe,Ibd investigators,Essen-Heidelberg Investigators,Amfs Investigators +183 more
TL;DR: Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma subtype is uniquely unrelated to pigmentation, and analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.
Journal ArticleDOI
Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study
Michael V. Holmes,Tabassome Simon,Tabassome Simon,Holly J. Exeter,Lasse Folkersen,Folkert W. Asselbergs,Montse Guardiola,Jackie A. Cooper,Jutta Palmen,Jaroslav A. Hubacek,Kathryn F. Carruthers,Benjamin D. Horne,Kimberly D. Brunisholz,Jessica L. Mega,Erik P A Van Iperen,Mingyao Li,Maarten Leusink,Stella Trompet,Jeffrey J. W. Verschuren,G. Kees Hovingh,Abbas Dehghan,Christopher P. Nelson,Salma Kotti,Nicolas Danchin,Nicolas Danchin,Markus Scholz,Christiane L Haase,Dietrich Rothenbacher,Dietrich Rothenbacher,Daniel I. Swerdlow,Karoline Kuchenbaecker,Eleonora Staines-Urias,Anuj Goel,Ferdinand Van 'T Hooft,Karl Gertow,Ulf de Faire,Andrie G. Panayiotou,Elena Tremoli,Damiano Baldassarre,Fabrizio Veglia,Lesca M. Holdt,Lesca M. Holdt,Frank Beutner,Ron T. Gansevoort,Gerjan Navis,Irene Mateo Leach,Lutz P. Breitling,Hermann Brenner,Joachim Thiery,Dhayana Dallmeier,Anders Franco-Cereceda,Jolanda M. A. Boer,Jeffrey W. Stephens,Marten H. Hofker,Alain Tedgui,Albert Hofman,André G. Uitterlinden,Vera Adamkova,Jan Pitha,N. Charlotte Onland-Moret,Maarten J. Cramer,Hendrik M. Nathoe,Wilko Spiering,Olaf H. Klungel,Meena Kumari,Peter H. Whincup,David A. Morrow,Peter S. Braund,Alistair S. Hall,Anders G. Olsson,Pieter A. Doevendans,Mieke D. Trip,Martin D. Tobin,Anders Hamsten,Hugh Watkins,Wolfgang Koenig,Andrew N. Nicolaides,Daniel Teupser,Daniel Teupser,Ian N.M. Day,John F. Carlquist,Tom R. Gaunt,Ian Ford,Naveed Sattar,Sotirios Tsimikas,Gregory G. Schwartz,Debbie A Lawlor,Richard W Morris,Manjinder S. Sandhu,Rudolf Poledne,Anke H. Maitland-van der Zee,Kay-Tee Khaw,Brendan J. Keating,Pim van der Harst,Jackie F. Price,Shamir R. Mehta,Salim Yusuf,Jaqueline C M Witteman,Oscar H. Franco,J. Wouter Jukema,Peter de Knijff,Anne Tybjærg-Hansen,Daniel J. Rader,Martin Farrall,Nilesh J. Samani,Mika Kivimäki,Keith A.A. Fox,Steve E. Humphries,Jeffrey L. Anderson,S. Matthijs Boekholdt,Tom Palmer,Per Eriksson,Guillaume Paré,Aroon D. Hingorani,Marc S. Sabatine,Ziad Mallat,Ziad Mallat,Juan P. Casas,Juan P. Casas,Philippa J. Talmud +119 more
TL;DR: In this paper, the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease was investigated by using a Mendelian randomization meta-analysis of 19 general population studies and 10 acute coronary syndrome (ACS) cohorts.