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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Vascular renin and hypertension. Uptake versus synthesis.
John D. Swales,Nilesh J. Samani +1 more
TL;DR: Using a ribonuclease protection technique for the detection of renin messenger RNA, it is shown that a wide variety of extrarenal tissues contain the renin message and that at least two of these, the brain and the liver, renin Messenger RNA levels are unaffected by changes in dietary salt or byChanges in systemic blood pressure.
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Two further blood pressure loci identified in ion channel genes with a gene-centric approach.
Nina S. McCarthy,Ciara Vangjeli,Gianpiero L. Cavalleri,Norman Delanty,Kevin V. Shianna,Praveen Surendran,Eoin O'Brien,Patricia B. Munroe,Nicholas Masca,Maciej Tomaszewski,Nilesh J. Samani,Alice Stanton +11 more
TL;DR: The results suggest that dense genotyping of genes, in pathways known to influence BP, could add to candidate-gene and Genome Wide Association studies in further explaining BP heritability.
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Disparity in implantable cardioverter defibrillator therapy among minority South Asians in the United Kingdom.
Amar R Mistry,Zakariyya Vali,Bharat Sidhu,Charley A. Budgeon,Matthew F Yuyun,Vivetha Pooranachandran,Xin Li,Michelle Newton,Jamie Watts,Kamlesh Khunti,Nilesh J. Samani,G. André Ng +11 more
TL;DR: Despite a universal and free healthcare system, ICD implantation rates were significantly lower in the South Asian than the Caucasian population residing in the UK, and this is due to cultural acceptance or an unbalanced consideration.
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Albuminuria as a marker of systemic congestion in patients with heart failure
Eva M Boorsma,Jozine M. ter Maaten,Kevin Damman,B. J. van Essen,Faiez Zannad,Dirk J. van Veldhuisen,Nilesh J. Samani,Kenneth Dickstein,Marco Metra,Gerasimos Filippatos,Chim C. Lang,Leong L. Ng,Stefan D. Anker,John G.F. Cleland,Pierpaolo Pellicori,Ron T. Gansevoort,Hiddo J.L. Heerspink,Adriaan A. Voors,Johanna E. Emmens +18 more
TL;DR: In patients with new-onset or worsening heart failure, albuminuria is consistently associated with clinical, echocardiographic, and circulating biomarkers of congestion.
Journal ArticleDOI
Cumulative effects of common genetic variants on risk of sudden cardiac death
Adriana Huertas-Vazquez,Christopher P. Nelson,Christopher P. Nelson,Janet S. Sinsheimer,Kyndaron Reinier,Audrey Uy-Evanado,Carmen Teodorescu,Jo Ayala,Alistair S. Hall,Karen Gunson,Jonathan Jui,Nilesh J. Samani,Nilesh J. Samani,Sumeet S. Chugh +13 more
TL;DR: Findings represent proof of concept for the additive effects of gene variants on SCD risk for next generation sequencing methodology.