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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
Chris I. Jones,Sarah L. Bray,Stephen F. Garner,Jonathan Stephens,Bernard de Bono,W. Angenent,David Bentley,Philippa Burns,Alison J. Coffey,Panos Deloukas,Mark E. Earthrowl,Richard W. Farndale,Marc Hoylaerts,Kerstin Koch,Angela Rankin,Catherine M. Rice,Jane Rogers,Nilesh J. Samani,Michael Steward,Adam Walker,Nicholas A. Watkins,Jan-Willem N. Akkerman,Frank Dudbridge,Alison H. Goodall,Willem H. Ouwehand,Willem H. Ouwehand +25 more
TL;DR: Novel insights are provided into key hubs within platelet signaling networks within collagen and adenosine-diphosphate signaling networks.
Journal ArticleDOI
A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study.
Nilesh J. Samani,Paul Burton,Massimo Mangino,Stephen G. Ball,Anthony J. Balmforth,Jenny Barrett,Timothy Bishop,Alistair S. Hall +7 more
TL;DR: In this article, a genomewide linkage analysis of 4,175 affected subjects from 1,933 families recruited throughout the United Kingdom was performed using 416 microsatellite markers.
Journal ArticleDOI
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease
Maria Sabater-Lleal,Jie Huang,Daniel I. Chasman,Silvia Naitza,Abbas Dehghan,Andrew D. Johnson,Alexander Teumer,Alexander P. Reiner,Lasse Folkersen,Saonli Basu,Alicja R. Rudnicka,Stella Trompet,Anders Mälarstig,Jens Baumert,Joshua C. Bis,Xiuqing Guo,Jouke J. Hottenga,So-Youn Shin,Lorna M. Lopez,Jari Lahti,Toshiko Tanaka,Lisa R. Yanek,Tiphaine Oudot-Mellakh,James F. Wilson,Pau Navarro,Jennifer E. Huffman,Tatijana Zemunik,Susan Redline,Reena Mehra,Drazen Pulanic,Igor Rudan,Alan F. Wright,Ivana Kolcic,Ozren Polasek,Sarah H. Wild,Harry Campbell,J. David Curb,Robert B. Wallace,Simin Liu,Charles B. Eaton,Diane M. Becker,Lewis C. Becker,Stefania Bandinelli,Katri Räikkönen,Elisabeth Widen,Aarno Palotie,Myriam Fornage,David Green,Myron D. Gross,Gail Davies,Sarah E. Harris,David C. Liewald,John M. Starr,Frances M K Williams,Peter J. Grant,Tim D. Spector,Rona J. Strawbridge,Angela Silveira,Bengt Sennblad,Fernando Rivadeneira,André G. Uitterlinden,Oscar H. Franco,Albert Hofman,Jenny van Dongen,Gonneke Willemsen,Dorret I. Boomsma,Jie Yao,Nancy S. Jenny,Talin Haritunians,Barbara McKnight,Thomas Lumley,Kent D. Taylor,Jerome I. Rotter,Bruce M. Psaty,Annette Peters,Christian Gieger,Thomas Illig,Anne Grotevendt,Georg Homuth,Henry Völzke,Thomas D. Kocher,Anuj Goel,Maria Grazia Franzosi,Udo Seedorf,Robert Clarke,Maristella Steri,Kirill V. Tarasov,Serena Sanna,David Schlessinger,David J. Stott,Naveed Sattar,Brendan M. Buckley,Ann Rumley,Gordon D.O. Lowe,Wendy L. McArdle,Ming-Huei Chen,Geoffrey H. Tofler,Jaejoon Song,Eric Boerwinkle,Aaron R. Folsom,Lynda M. Rose,Anders Franco-Cereceda,Martina Teichert,M. Arfan Ikram,Thomas H. Mosley,Steve Bevan,Martin Dichgans,Peter M. Rothwell,Cathie Sudlow,Jemma C. Hopewell,John C. Chambers,Danish Saleheen,Jaspal S. Kooner,John Danesh,Christopher P. Nelson,Jeanette Erdmann,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Pierre-Emmanuel Morange,Luigi Ferrucci,Johan G. Eriksson,David R. Jacobs,Ian J. Deary,Nicole Soranzo,Jacqueline C.M. Witteman,Eco J. C. de Geus,Russell P. Tracy,Caroline Hayward,Wolfgang Koenig,Francesco Cucca,J. Wouter Jukema,Per Eriksson,Sudha Seshadri,Hugh S. Markus,Hugh Watkins,Nilesh J. Samani,Henri Wallaschofski,Nicholas L. Smith,David-Alexandre Trégouët,Paul M. Ridker,Weihong Tang,David P. Strachan,Anders Hamsten,Christopher J. O'Donnell +144 more
TL;DR: Clinical outcome analysis of these loci does not support a causal relationship between circulating levels of fibrinogen and coronary artery disease, stroke, or venous thromboembolism.
Journal ArticleDOI
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Sara Hägg,Sara Hägg,Sara Hägg,Tove Fall,Tove Fall,Tove Fall,Alexander Ploner,Reedik Mägi,Krista Fischer,Harmen H.M. Draisma,Mart Kals,Paul S. de Vries,Abbas Dehghan,Sara M. Willems,Antti-Pekka Sarin,Antti-Pekka Sarin,Kati Kristiansson,Marja-Liisa Nuotio,Aki S. Havulinna,Renée F A G de Bruijn,M. Arfan Ikram,Maris Kuningas,Bruno H. Stricker,Oscar H. Franco,Beben Benyamin,Christian Gieger,Alistair S. Hall,Ville Huikari,Antti Jula,Marjo-Riitta Järvelin,Marika Kaakinen,Jaakko Kaprio,Michael Kobl,Massimo Mangino,Christopher P. Nelson,Aarno Palotie,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Martin D. Tobin,John Whitfield,André G. Uitterlinden,Veikko Salomaa,Ann-Christine Syvänen,Ann-Christine Syvänen,Kari Kuulasmaa,Patrik K. E. Magnusson,Tõnu Esko,Albert Hofman,Eco J. C. de Geus,Lars Lind,Vilmantas Giedraitis,Markus Perola,Alun Evans,Jean Ferrières,Jarmo Virtamo,Frank Kee,David-Alexandre Trégouët,Dominique Arveiler,Philippe Amouyel,Francesco Gianfagna,Paolo Brambilla,Samuli Ripatti,Cornelia M. van Duijn,Andres Metspalu,Inga Prokopenko,Mark I. McCarthy,Nancy L. Pedersen,Erik Ingelsson +68 more
TL;DR: In this paper, the effect of body mass index (BMI) on risk of cardiovascular diseases was investigated using Mendelian randomization (MR) methods, and the results indicated a strong association between BMI and incident coronary heart disease (CHD), heart failure, and ischaemic stroke.
Journal ArticleDOI
Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction
Dominic Kelly,Sohail Q. Khan,Matt M. Thompson,Gillian Cockerill,Leong L. Ng,Nilesh J. Samani,Iain B. Squire +6 more
TL;DR: TIMP-1 and MMP-9 correlate with echocardiographic parameters of LV dysfunction and remodelling after AMI and may identify patients at risk of subsequent LV remodelling and adverse prognosis.