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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Joanna M. M. Howson,Wei Zhao,Daniel R. Barnes,Weang Kee Ho,Robin Young,Dirk S. Paul,Lindsay L. Waite,Daniel F. Freitag,Eric B. Fauman,Elias Salfati,Benjamin B. Sun,John D. Eicher,Andrew D. Johnson,Wayne Huey-Herng Sheu,Sune F. Nielsen,Wei-Yu Lin,Praveen Surendran,Anders Mälarstig,Jemma B. Wilk,Anne Tybjærg-Hansen,Katrine L. Rasmussen,Pia R. Kamstrup,Panos Deloukas,Jeanette Erdmann,Sekar Kathiresan,Nilesh J. Samani,Heribert Schunkert,Hugh Watkins,CARDIoGRAMplusC D,Ron Do,Daniel J. Rader,Julie A. Johnson,Stanley L. Hazen,Arshed A. Quyyumi,John A. Spertus,Carl J. Pepine,Nora Franceschini,Anne E. Justice,Alexander P. Reiner,Steven Buyske,Lucia A. Hindorff,Cara L. Carty,Kari E. North,Charles Kooperberg,Eric Boerwinkle,Kristin L. Young,Mariaelisa Graff,Ulrike Peters,Devin Absher,Chao A. Hsiung,Wen-Jane Lee,Kent D. Taylor,Ying-Hsiang Chen,I-Te Lee,Xiuqing Guo,Ren-Hua Chung,Yi-Jen Hung,Jerome I. Rotter,Jyh-Ming Jimmy Juang,Thomas Quertermous,Tzung-Dau Wang,Asif Rasheed,Philippe M. Frossard,Dewan S. Alam,Abdulla Al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Epic-Cvd,Epic-Cvd,Yii-Der Ida Chen,Børge G. Nordestgaard,Themistocles L. Assimes,John Danesh,Adam S. Butterworth,Danish Saleheen +74 more
TL;DR: 25 new SNP–CAD associations are identified from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis, coagulation and inflammation and vascular smooth muscle cell differentiation, which sheds light on potential disease mechanisms.
Journal ArticleDOI
Mapping of a Major Locus that Determines Telomere Length in Humans
Mariuca Vasa-Nicotera,S. W. Brouilette,Massimo Mangino,John R. Thompson,Peter S. Braund,Jenny-Rebecca Clemitson,Andrea Mason,Clare L. Bodycote,Stuart M Raleigh,Edward J. Louis,Nilesh J. Samani +10 more
TL;DR: Mapping of the first locus that determines mean telomere length in humans is reported, and preliminary analysis of a strong candidate gene in the region, the DNA helicase DDX11, is presented.
Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal ArticleDOI
Dysfunctional nitric oxide signalling increases risk of myocardial infarction
Jeanette Erdmann,Klaus Stark,Ulrike B. Esslinger,Philipp Moritz Rumpf,Doris Koesling,Cor de Wit,Frank J. Kaiser,Diana Braunholz,Anja Medack,Marcus Fischer,Martina E. Zimmermann,Stephanie Tennstedt,Elisabeth Graf,Sebastian H. Eck,Zouhair Aherrahrou,Janja Nahrstaedt,Christina Willenborg,Petra Bruse,Ingrid Braenne,Markus M. Nöthen,Per Hofmann,Peter S. Braund,Evanthia Mergia,Wibke Reinhard,Christof Burgdorf,Stefan Schreiber,Anthony J. Balmforth,Alistair S. Hall,Lars Bertram,Elisabeth Steinhagen-Thiessen,Shu-Chen Li,Winfried März,Muredach P. Reilly,Sekar Kathiresan,Ruth McPherson,Ulrich Walter,Jurg Ott,Nilesh J. Samani,Tim M. Strom,Thomas Meitinger,Christian Hengstenberg,Heribert Schunkert +41 more
TL;DR: Starting with a severely affected family, this work has identified a link between impaired soluble-guanylyl-cyclase-dependent nitric oxide signalling and myocardial infarction risk, possibly through accelerated thrombus formation, and demonstrated in vitro that mutations in both GUCY1A3 and CCT7 severely reduce α1-sGC as well as β1- sGC protein content, and impair soluble guanyly l cyclase activity.
Journal ArticleDOI
Genetically determined height and coronary artery disease
Christopher P. Nelson,Stephen E. Hamby,Danish Saleheen,Jenna C Hopewell,Lingyao Zeng,Themistocles L. Assimes,Stavroula Kanoni,Christina Willenborg,Stephen Burgess,Philippe Amouyel,Sonia S. Anand,Stefan Blankenberg,Bernhard O. Boehm,Robert Clarke,Rory Collins,George Dedoussis,Martin Farrall,Paul W. Franks,Leif Groop,Alistair S. Hall,Anders Hamsten,Christian Hengstenberg,G. Kees Hovingh,Erik Ingelsson,Sekar Kathiresan,Frank Kee,Inke R. König,Jaspal S. Kooner,Terho Lehtimäki,W. März,Ruth McPherson,Andres Metspalu,Markku S. Nieminen,Christopher J. O'Donnell,Colin N. A. Palmer,Annette Peters,Markus Perola,Muredach P. Reilly,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Svati H. Shah,Stefan Schreiber,Agneta Siegbahn,Unnur Thorsteinsdottir,Giovani Veronesi,Nicholas J. Wareham,Cristen J. Willer,Pierre Zalloua,Jeanette Erdmann,Panos Deloukas,Hugh Watkins,Heribert Schunkert,John Danesh,John R. Thompson,Nilesh J. Samani +55 more
TL;DR: There is a primary association between a genetically determined shorterheight and an increased risk of CAD, a link that is partly explained by the association between shorter height and an adverse lipid profile.