N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Norihiro Kato,Marie Loh,Marie Loh,Marie Loh,Fumihiko Takeuchi,Niek Verweij,Xu Wang,Weihua Zhang,Tanika NKelly,Danish Saleheen,Danish Saleheen,Benjamin Lehne,Irene Mateo Leach,Alexander W. Drong,James Abbott,Simone Wahl,Sian Tsung Tan,William R. Scott,Gianluca Campanella,Marc Chadeau-Hyam,Uzma Afzal,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Marc Jan Bonder,Peng Chen,Abbas Dehghan,Todd L. Edwards,Tõnu Esko,Min Jin Go,Sarah E. Harris,Jaana Hartiala,Silva Kasela,Anuradhani Kasturiratne,Chiea Chuen Khor,Marcus E. Kleber,Huaixing Li,Zuan Yu Mok,Masahiro Nakatochi,Nur Sabrina Sapari,Richa Saxena,Alexandre F.R. Stewart,Lisette Stolk,Yasuharu Tabara,Ai Ling Teh,Ying Wu,Jer-Yuarn Wu,Yi Zhang,Imke Aits,Alexessander Couto Alves,Shikta Das,Rajkumar Dorajoo,Jemma CHopewell,Yun Kyoung Kim,Robert WKoivula,Jian'an Luan,Leo-Pekka Lyytikäinen,Quang NNguyen,Mark A. Pereira,Iris Postmus,Olli TRaitakari,Molly Scannell Bryan,Robert A. Scott,Rossella Sorice,Vinicius Tragante,Michela Traglia,Jon White,Ken Yamamoto,Yonghong Zhang,Linda S. Adair,Alauddin Ahmed,Koichi Akiyama,Rasheed Asif,Tin Aung,Inês Barroso,Andrew Bjonnes,Timothy R. Braun,Hui Cai,Li Ching Chang,Chien Hsiun Chen,Ching-Yu Cheng,Yap Seng Chong,Yap Seng Chong,Rory Collins,Regina Courtney,Gail Davies,Graciela E. Delgado,Loi D. Do,Pieter A. Doevendans,Ron T. Gansevoort,Yu-Tang Gao,Tanja B. Grammer,Niels Grarup,Jagvir Grewal,Dongfeng Gu,Gurpreet SWander,Anna-Liisa Hartikainen,Stanley L. Hazen,Jing He,Chew-Kiat Heng,E. James Ames Hixso,Albert Hofman,Chris Hsu,Wei Huang,Lise Lotte N. Husemoen,Joo Yeon Hwang,Sahoko Ichihara,Michiya Igase,Masato Isono,Johanne Marie Justesen,Tomohiro Katsuya,Muhammad GKibriya,Young Jin Kim,Miyako Kishimoto,Woon-Puay Koh,Katsuhiko Kohara,Meena Kumari,Kenneth Kwek,Nanette R. Lee,Jeannette Lee,Jiemin Liao,Jiemin Liao,Wolfgang Lieb,David C. Liewald,Tatsuaki Matsubara,Yumi Matsushita,Thomas Meitinger,Evelin Mihailov,Lili Milani,Rebecca Mills,Nina Mononen,Martina Müller-Nurasyid,Toru Nabika,Eitaro Nakashima,Hong Kiat Ng,Kjell Nikus,Teresa Nutile,Takayoshi Ohkubo,Keizo Ohnaka,Sarah Parish,Lavinia Paternoster,Hao Peng,Annette Peters,Son TPham,M.J. Pinidiyapathirage,Mahfuzar Rahman,Hiromi Rakugi,Olov Rolandsson,Michelle Ann Rozario,Daniela Ruggiero,Cinzia Sala,Ralhan Sarju,Kazuro Shimokawa,Harold Snieder,Thomas Sparsø,Wilko Spiering,John M. Starr,David J. Stott,Daniel OStram,Takao Sugiyama,Silke Szymczak,W.H. Wilson Tang,Lin Tong,Stella Trompet,Väinö Turjanmaa,Hirotsugu Ueshima,André G. Uitterlinden,Satoshi Umemura,Marja Vääräsmäki,Rob M. van Dam,Wiek H. van Gilst,Dirk J. van Veldhuisen,Jorma Viikari,Melanie Waldenberger,Yiqin Wang,Aili Wang,Rory P. Wilson,Tien Yin Wong,Tien Yin Wong,Yong-Bing Xiang,Shuhei Yamaguchi,Xingwang Ye,Robin Young,Terri L. Young,Jian-Min Yuan,Xueya Zhou,Folkert W. Asselbergs,Folkert W. Asselbergs,Marina Ciullo,Robert Clarke,Panos Deloukas,Panos Deloukas,Andre Franke,W. Frank Paul,Steve Franks,Yechiel Friedlander,Myron D. Gross,Zhirong Guo,Torben Hansen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Torben Jørgensen,J. Wouter Jukema,Mika Kähönen,Hiroshi Kajio,Mika Kivimäki,Jong-Young Lee,Terho Lehtimäki,Allan Linneberg,Tetsuro Miki,Oluf Pedersen,Nilesh J. Samani,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Ryoichi Takayanagi,Daniela Toniolo,Habibul Ahsan,Hooman Allayee,Yuan-Tsong Chen,John Danesh,John Danesh,Ian J. Deary,Oscar H. Franco,Lude Franke,Bastiaan THeijman,Joanna D. Holbrook,Aaron Isaacs,Bong Jo Kim,Xu Lin,Jianjun Liu,Winfried März,Andres Metspalu,Karen L. Mohlke,K. Sangher,Dharambir Harambir,Xiao-Ou Shu,Joyce B. J. van Meurs,Eranga N. Vithana,Ananda R. Wickremasinghe,Cisca Wijmenga,Bruce H W Wolffenbuttel,Mitsuhiro Yokota,Wei Zheng,Dingliang Zhu,Paolo Vineis,Soterios A. Kyrtopoulos,Jos C. S. Kleinjans,Mark I. McCarthy,Richie Soong,Christian Gieger,James Scott,Yik Ying Teo,Jiang He,Paul Elliott,E. Shyong Tai,Pim van der Harst,Jaspal S. Kooner,John C. Chambers +256 more
TL;DR: The trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry finds genetic variants at 12 new loci to be associated with blood pressure, providing new evidence for the role of DNA methylation in blood pressure regulation.
Journal ArticleDOI
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Lia Crotti,Pim van der Harst,Patricia B. Munroe,Tamara T. Koopmann,Nona Sotoodehnia,Elizabeth J. Rossin,Elizabeth J. Rossin,Michael Morley,Xinchen Wang,Xinchen Wang,Andrew D. Johnson,Alicia Lundby,Alicia Lundby,Daniel F. Gudbjartsson,Peter A. Noseworthy,Peter A. Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M. Lahtinen,Ilja M. Nolte,Albert V. Smith,Joshua C. Bis,Aaron Isaacs,Stephen Newhouse,Daniel S. Evans,Wendy S. Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A. Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J. Tester,Stéphanie Chatel,Stefan Gustafsson,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa Torinsson Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G. Panayiotou,María Dolores Torres,Michael Knoflach,Jaroslav A. Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Runjun D. Kumar,Tamara B. Harris,Lenore J. Launer,Alan R. Shuldiner,Alan R. Shuldiner,Alvaro Alonso,Joel S. Bader,Georg Ehret,Hailiang Huang,Hailiang Huang,W. H. Linda Kao,James B. Strait,Peter W. Macfarlane,Morris Brown,Mark J. Caulfield,Nilesh J. Samani,Florian Kronenberg,Johann Willeit,J. Gustav Smith,J. Gustav Smith,J. Gustav Smith,Karin Halina Greiser,Karin Halina Greiser,Henriette E. Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Ivana Kolcic,Ozren Polasek,Alan F. Wright,Maura Griffin,Mark J. Daly,Mark J. Daly,David O. Arnar,Hilma Holm,Unnur Thorsteinsdottir,Joshua C. Denny,Dan M. Roden,Rebecca L. Zuvich,Valur Emilsson,Andrew S. Plump,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Xiaoyan Yin,Xiaoyan Yin,Marco Bobbo,Adamo Pio D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R. Cummings,Mike A. Nalls,Antti Jula,Kimmo Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Markus Perola,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M. Nöthen,Marcel den Hoed,Marcel den Hoed,Ruth J. F. Loos,Ruth J. F. Loos,Dag S. Thelle,Dag S. Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F. Sinner,Melanie Waldenberger,Rudolf A. de Boer,Lude Franke,Pieter A. van der Vleuten,Britt M. Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A.M. Wilde,Elijah R. Behr,Chrysoula Dalageorgou,John R. Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M. Hamilton,Stephen W. Scherer,Jeffrey Brandimarto,Kenneth B. Margulies,Christine E. Moravec,Fabiola Del Greco M,Christian Fuchsberger,Jeffrey R. O'Connell,Wai K. Lee,Graham Watt,Harry Campbell,Sarah H Wild,Nour Eddine El Mokhtari,Norbert Frey,Folkert W. Asselbergs,Folkert W. Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P. van den Berg,Dirk J. van Veldhuisen,Manolis Kellis,Manolis Kellis,Bouwe P. Krijthe,Oscar H. Franco,Albert Hofman,Jan A. Kors,André G. Uitterlinden,Jacqueline C.M. Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A. Oostra,Gonçalo R. Abecasis,Edward G. Lakatta,Antonella Mulas,Marco Orru,David Schlessinger,Manuela Uda,Marcello Ricardo Paulista Markus,Uwe Völker,Harold Snieder,Tim D. Spector,Johan Ärnlöv,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimäki,Mika Kähönen,Nina Mononen,Olli T. Raitakari,Jorma S. A. Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N. Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F. Dominiczak,Fredrik Nyberg,Fredrik Nyberg,Peter H. Whincup,Aroon D. Hingorani,Jean-Jacques Schott,Connie R. Bezzina,Erik Ingelsson,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini,James F. Wilson,Igor Rudan,Andre Franke,Thomas W. Mühleisen,Peter P. Pramstaller,Terho Lehtimäki,Andrew D. Paterson,Afshin Parsa,Yongmei Liu,Cornelia M. van Duijn,David S. Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B. Felix,Serena Sanna,Marylyn D. Ritchie,Bruno H. Stricker,Kari Stefansson,Laurie A. Boyer,Thomas P. Cappola,Jesper V. Olsen,Kasper Lage,Peter J. Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J. Ackerman,Arne Pfeufer,Paul I.W. de Bakker,Christopher Newton-Cheh,Christopher Newton-Cheh +260 more
TL;DR: In this paper, the authors identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.
Journal ArticleDOI
The impact of low-frequency and rare variants on lipid levels.
Ida Surakka,Ida Surakka,Momoko Horikoshi,Reedik Mägi,Antti-Pekka Sarin,Antti-Pekka Sarin,Anubha Mahajan,Vasiliki Lagou,Letizia Marullo,Teresa Ferreira,Benjamin Miraglio,Sanna Timonen,Johannes Kettunen,Johannes Kettunen,Matti Pirinen,Juha Karjalainen,Gudmar Thorleifsson,Sara Hägg,Sara Hägg,Jouke-Jan Hottenga,A Isaacs,A Isaacs,A Isaacs,Claes Ladenvall,Marian Beekman,Tõnu Esko,Janina S. Ried,Christopher P. Nelson,Christina Willenborg,Stefan Gustafsson,Stefan Gustafsson,Harm-Jan Westra,Matthew Blades,Anton J. M. de Craen,Eco J. C. de Geus,Joris Deelen,Harald Grallert,Anders Hamsten,Aki S. Havulinna,Christian Hengstenberg,Jeanine J. Houwing-Duistermaat,Elina Hyppönen,Lennart C. Karssen,Terho Lehtimäki,Valeriya Lyssenko,Patrik K. E. Magnusson,Evelin Mihailov,Martina Müller-Nurasyid,John Patrick Mpindi,Nancy L. Pedersen,Brenda W.J.H. Penninx,Markus Perola,Tune H. Pers,Tune H. Pers,Annette Peters,Johan Rung,Johannes H. Smit,Valgerdur Steinthorsdottir,Martin D. Tobin,Natalia Tšernikova,Elisabeth M. van Leeuwen,Jorma Viikari,Sara M. Willems,Gonneke Willemsen,Heribert Schunkert,Jeanette Erdmann,Nilesh J. Samani,Jaakko Kaprio,Jaakko Kaprio,Lars Lind,Christian Gieger,Andres Metspalu,P. Eline Slagboom,Leif Groop,Cornelia M. van Duijn,Johan G. Eriksson,Antti Jula,Veikko Salomaa,Dorret I. Boomsma,Christine Power,Olli T. Raitakari,Erik Ingelsson,Erik Ingelsson,Marjo-Riitta Järvelin,Unnur Thorsteinsdottir,Lude Franke,Elina Ikonen,Olli Kallioniemi,Vilja Pietiäinen,Cecilia M. Lindgren,Cecilia M. Lindgren,Kari Stefansson,Aarno Palotie,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Inga Prokopenko,Samuli Ripatti +98 more
TL;DR: Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, association to lipid traits in 93 loci is identified, including 79 previously identified loci with new lead SNPs and 10 new loci, including 15 locu with a low-frequency lead SNP and 10 loco with a missense lead SNP.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena,Richa Saxena,Clara C. Elbers,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Archana Tare,Berta Almoguera Castillo,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten,Robert A. Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +163 more
TL;DR: Large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to type 2 diabetes risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg Ehret,Teresa Ferreira,Daniel I. Chasman,Anne U. Jackson,Ellen M. Schmidt,Toby Johnson,Gudmar Thorleifsson,Jian'an Luan,Louise A. Donnelly,Stavroula Kanoni,Ann-Kristin Petersen,Vasyl Pihurl,Rona J. Strawbridge,Dmitry Shungin,Maria Hughes,Osorio Meirelles,Marika Kaakinen,Nabila Bouatia-Naji,Kati Kristiansson,Sonia Shah,Marcus E. Kleber,Xiuqing Guo,Leo-Pekka Lyytikäinen,Cristiano Fava,Nidas Eriksson,Ilja M. Nolte,Patrik K. E. Magnusson,Elias Salfati,Loukianos S. Rallidis,Elizabeth Theusch,Andrew J. Smith,Lasse Folkersen,Kate Witkowska,Tune H. Pers,Roby Joehanes,Stuart K. Kim,Lazaros Lataniotis,Rick Jansen,Andrew D. Johnson,Helen R. Warren,Young Jin Kim,Wei Zhao,Ying Wu,Bamidele O. Tayo,Murielle Bochud,Devin Absher,Linda S. Adair,Najaf Amin,Dan E. Arkingl,Tomas Axelsson,Damian Baldassarre,Beverley Balkau,Stefania Bandinelli,Michael R. Barnes,Inês Barroso,Stephen Bevan,Joshua C. Bis,Gyda Bjornsdottir,Michael Boehnke,Eric Boerwinkle,Lori L. Bonnycastle,Dorret I. Boomsma,Stefan R. Bornstein,Morris Brown,Michel Burnier,Claudia P. Cabrera,John C. Chambers,I-Shou Chang,Ching-Yu Cheng,Peter S. Chines,Ren-Hua Chung,Francis S. Collins,John M. C. Connell,Angela Döring,Jean Dallongeville,John Danesh,Ulf de Faire,Graciela E. Delgado,Anna F. Dominiczak,Alex S. F. Doney,Fotios Drenos,Sarah Edkins,John D. Eicher,Roberto Elosua,Stefan Enroth,Jeanette Erdmann,Per Eriksson,Tõnu Esko,Evangelos Evangelou,Alun Evans,Tove Fai,Martin Farra,Janine F. Felixl,Jean Ferrières,Luigi Ferrucci,Myriam Fornage,Terrence Forrester,Nora Franceschinil,Oscar H. Franco,Anders Franco-Cereceda,Ross M. Fraser,Santhi K. Ganesh,He Gao,Karl Gertow,Francesco Gianfagna,Bruna Gigante,Franco Giulianini,Anuj Goe,Alison H. Goodall,Mark O. Goodarzi,Mathias Gorski,Jürgen Grässler,Christopher J. Groves,Vilmundur Gudnason,Ulf Gyllensten,Göran Hallmans,Anna-Liisa Hartikainen,Maija Hassinen,Aki S. Havulinna,Caroline Hayward,Serge Hercberg,Karl-Heinz Herzig,Andrew A. Hicks,Aroon D. Hingorani,Joel N. Hirschhorn,Albert Hofmanl,Jostein Holmen,Oddgeir L. Holmen,Jouke-Jan Hottenga,Phil Howard,Chao A. Hsiung,Steven C. Hunt,M. Arfan Ikram,Thomas Illig,Carlos Iribarren,Richard A. Jensen,Mika Kähönen,Hyun Min Kang,Sekar Kathiresan,Brendan J. Keating,Kay-Tee Khaw,Yun Kyoung Kim,Eric Kim,Mika Kivimäki,Norman Klopp,Genovefa Kolovou,Pirjo Komulainen,Jaspal S. Kooner,Gulum Kosova,Ronald M. Krauss,Diana Kuh,Zoltán Kutalik,Johanna Kuusisto,Kirsti Kvaløy,Timo A. Lakka,Nanette R. Lee,I-Te Lee,Wen-Jane Lee,Daniel Levy,Xiaohui Li,Kae-Woei Liang,Honghuang Lin,Li Lin,Jaana Lindström,Stéphane Lobbens,Satu Männistö,Gabriele Müller,Martina Müller-Nurasyid,François Mach,Hugh S. Markus,Eirini Marouli,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Cristina Menni,Andres Metspalu,Vladan Mijatovic,Leena Moilanen,May E. Montasser,Andrew D. Morris,Alanna C. Morrison,Antonella Mulas,Ramaiah Nagaraja,Narisu Narisu,Kjell Nikus,Christopher J. O'Donnell,Paul F. O'Reilly,Ken K. Ong,Fred Paccaud,Cameron D. Palmer,Afshin Parsa,Nancy L. Pedersen,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Neil Poulter,Peter P. Pramstaller,Bruce M. Psaty,Thomas Quertermous,Dabeeru C. Rao,Asif Rasheed,N. William Rayner,Frida Renström,Rainer Rettig,Kenneth Rice,Robert Roberts,Lynda M. Rose,Jacques E. Rossouw,Nilesh J. Samani,Serena Sanna,Jouko Saramies,Heribert Schunkert,Sylvain Sebert,Wayne H-H Sheu,Young-Ah Shin,Xueling Sim,Johannes H. Smit,Albert V. Smith,Maria X. Sosa,Tim D. Spector,Alena Stančáková,Alice Stanton,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Amy J. Swift,Ann-Christine Syvänen,E-Shyong Tai,Toshiko Tanaka,Kirill Tarasov,Alexander Teumer,Unnur Thorsteinsdottir,Martin D. Tobin,Elena Tremoli,André G. Uitterlinden,Matti Uusitupa,Ahmad Vaez,Dhananjay Vaidya,Cornelia M. van Duijn,Erik P A Van Iperen,Ramachandran S. Vasan,Germaine C. Verwoert,Jarmo Virtamo,Veronique Vitart,Benjamin F. Voight,Peter Vollenweider,Aline Wagner,Louise V. Wain,Nicholas J. Wareham,Hugh Watldns,Alan B. Weder,Harm-Jan Westra,Rainford J. Wilks,Tom Wilsgaard,James F. Wilson,Tien Yin Wong,Tsun-Po Yang,Jie Yao,Loic Yengo,Weihua Zhang,Jing Hua Zhao,Xiaofeng Zhu,Pascal Bovet,Richard S. Cooper,Karen L. Mohlke,Danish Saleheen,Jong-Young Lee,Paul Elliott,Hinco J. Gierman,Cristen J. Willer,Lude Franke,G. Kees Hovingh,Kent D. Taylor,George Dedoussis,Peter S. Sever,Andrew Wong,Lars Lind,Themistocles L. Assimes,Inger Njølstad,Peter Schwarz,Claudia Langenberg,Harold Snieder,Mark J. Caulfield,E. Melander,Markku Laakso,Juha Saltevo,Rainer Rauramaa,Jaakko Tuomilehto,Erik Ingelsson,Terho Lehtimäki,Kristian Hveem,Walter Palmas,Winfried März,Meena Kumar,Veikko Salomaa,Yii-Der Ida Chen,Jerome I. Rotter,Philippe Froguel,Marjo-Riitta Järvelin,Edward G. Lakatta,Kari Kuulasmaa,Paul W. Franks,Anders Hamsten,H-Erich Wichmann,Colin N. A. Palmer,Kari Stefansson,Paul M. Ridker,Ruth J. F. Loos,Aravinda Chalcravarti,Panos Deloukas,Andrew P. Morris,Christopher Newton-Cheh,Patricia B. Munroe +312 more
TL;DR: The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney, expanding current knowledge of blood pressure–related pathways and highlighting tissues beyond the classical renal system in blood pressure regulation.