N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
Papers
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Journal ArticleDOI
Telomere length and outcome in heart failure.
Pim van der Harst,Rudolf A. de Boer,Nilesh J. Samani,Liza S. M. Wong,Jardi Huzen,Veryan Codd,Hans L. Hillege,Adriaan A. Voors,Wiek H. van Gilst,Tiny Jaarsma,Dirk J. van Veldhuisen +10 more
TL;DR: Shorter length of telomeres predicts the occurrence of death or hospitalization in patients with chronic heart failure.
Journal ArticleDOI
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
Ilja M. Nolte,Chris Wallace,Stephen Newhouse,Daryl Waggott,Jingyuan Fu,Nicole Soranzo,Nicole Soranzo,Rhian Gwilliam,Panos Deloukas,Irina Savelieva,Dongling Zheng,Chrysoula Dalageorgou,Martin Farrall,Nilesh J. Samani,John M. C. Connell,Morris J. Brown,Anna F. Dominiczak,Mark Lathrop,Eleftheria Zeggini,Eleftheria Zeggini,Louise V. Wain,Christopher Newton-Cheh,Mark Eijgelsheim,Kenneth R. Rice,Kenneth R. Rice,Paul I.W. de Bakker,Paul I.W. de Bakker,Arne Pfeufer,Serena Sanna,Dan E. Arking,Folkert W. Asselbergs,Tim D. Spector,Nicholas D. Carter,Steve Jeffery,Martin D. Tobin,Mark J. Caulfield,Mark J. Caulfield,Harold Snieder,Andrew D. Paterson,Patricia B. Munroe,Yalda Jamshidi +40 more
TL;DR: The association between common variants near NOS1AP and the phospholamban gene and PLN, a key regulator of cardiac diastolic function and involved in regulating intracellular calcium cycling, and the QT interval are confirmed.
Journal ArticleDOI
Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses
Luanluan Sun,Lisa Pennells,Stephen Kaptoge,Christopher P. Nelson,Scott C. Ritchie,Scott C. Ritchie,Gad Abraham,Gad Abraham,Matthew Arnold,Steven Bell,Thomas A. W. Bolton,Stephen Burgess,Frank Dudbridge,Qi Guo,Eleni Sofianopoulou,David Stevens,John R. Thompson,Adam S. Butterworth,Angela M. Wood,John Danesh,John Danesh,Nilesh J. Samani,Michael Inouye,Michael Inouye,Michael Inouye,Emanuele Di Angelantonio +25 more
TL;DR: Sun et al. as mentioned in this paper used the Big Data@Heart initiative to support the development of a Big Data-based approach for the analysis of heart disease data, which was supported by the British Heart Foundation and Wellcome.
Journal ArticleDOI
Association analysis of β2 adrenoceptor polymorphisms with hypertension in a Black African population
Geoff Candy,Nilesh J. Samani,Gavin R. Norton,Angela J. Woodiwiss,I.V. Radevski,Amanda Wheatley,John R. Cockcroft,Ian P. Hall +7 more
TL;DR: It is suggested that β2AR polymorphism is not a risk factor for hypertension per se in this defined population and the possibility that the decreased prevalence of Glu27 in black South African populations explains blunted vasodilator responses to isoprenaline requires further study.
Journal ArticleDOI
Selenium and outcome in heart failure.
Nils Bomer,Niels Grote Beverborg,Martijn F Hoes,Koen W. Streng,Mathilde C.S.C. Vermeer,Martin M Dokter,Jan IJmker,Stefan D. Anker,John G.F. Cleland,Hans L. Hillege,Chim C. Lang,Leong L. Ng,Nilesh J. Samani,Jasper Tromp,Dirk J. van Veldhuisen,Daan J Touw,Adriaan A. Voors,Peter van der Meer +17 more
TL;DR: Whether, in clinical practice, moderate selenium deficiency is associated with worse symptoms and outcome in patients with heart failure is unknown and the mechanism at cellular level is uncertain.