N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.
Rachael A. Evans,Hamish McAuley,Ewen M Harrison,Aarti Shikotra,Amisha Singapuri,Marco Sereno,Omer Elneima,Annemarie B Docherty,Nazir I Lone,Nazir I Lone,Olivia C. Leavy,Luke Daines,J Kenneth Baillie,J Kenneth Baillie,Jeremy S. Brown,Trudie Chalder,Anthony De Soyza,Nawar Diar Bakerly,Nawar Diar Bakerly,Nicholas Easom,John R. Geddes,John R. Geddes,Neil J. Greening,Nicholas Hart,Liam G Heaney,Liam G Heaney,Simon Heller,Luke Howard,John R. Hurst,Joseph Jacob,R. Gisli Jenkins,Caroline J. Jolley,Steven Kerr,Onn Min Kon,Onn Min Kon,Keir Lewis,Janet M. Lord,Gerry P McCann,Stefan Neubauer,Peter J. M. Openshaw,Dhruv Parekh,Dhruv Parekh,Paul E Pfeffer,Paul E Pfeffer,Najib M. Rahman,Betty Raman,Matthew Richardson,Matthew J. Rowland,Malcolm G Semple,Malcolm G Semple,Ajay M. Shah,Sally J Singh,Aziz Sheikh,David B. Thomas,Mark Toshner,James D. Chalmers,Ling-Pei Ho,Alex Horsley,Michael Marks,Michael Marks,Krisnah Poinasamy,Louise V. Wain,Christopher E. Brightling,Kathryn M. Abel,Huzaifa Adamali,Davies Adeloye,O Adeyemi,F Adeyemi,S Ahmad,R Ahmed,M Ainsworth,A Alamoudi,M Aljaroof,Louise Allan,R Allen,A Alli,B Al-Sheklly,D Altmann,Denise Anderson,M Andrews,A Angyal,Charalambos Antoniades,Gill Arbane,Cherie Armour,N Armstrong,Lynne Armstrong,H Arnold,David T Arnold,Milton Ashworth,A Ashworth,H Assefa-Kebede,P Atkin,H Atkins,A Atkins,R Aul,C Avram,R Baggott,D Baguley,J K Baillie,S Bain,M Bakali,M Bakau,Emma Baldry,David R Baldwin,Clive Ballard,J Bambrough,Ruth E Barker,Shaney L Barratt,F Barrett,N Basu,Rachel L. Batterham,H Baxendale,Hannah Bayes,M Bayley,Michael Beadsworth,P Beirne,R Bell,Derek Bell,Colin Berry,S Betts,K Bhui,L Bishop,J Blaikely,C Bloomfield,A Bloss,A Bolger,C E Bolton,J Bonnington,A Botkai,M Bourne,C Bourne,E Bradley,K Bramham,L Brear,Gerome Breen,J Breeze,A Briggs,E Bright,C E Brightling,Simon E. Brill,K Brindle,L Broad,M Broome,J S Brown,Matthew A. Brown,Jamie Brown,Richard G. Brown,V Brown,Ashley C. Brown,Traolach S. Brugha,Nigel J. Brunskill,M Buch,A Bularga,Edward T. Bullmore,David J. Burn,G Burns,Jonathan P. Busby,A.J. Buttress,S Byrne,P Cairns,P C Calder,E Calvelo,B Card,L Carr,Gail Carson,Patrice Carter,J Cavanagh,T Chalder,J D Chalmers,Rachel C. Chambers,Keith M. Channon,Kath Chapman,A Charalambou,N Chaudhuri,A Checkley,J Chen,L Chetham,E R Chilvers,H Chinoy,K Chong-James,N Choudhury,G Choudhury,P Chowdhury,P Chowienczyk,C Christie,David W. Clark,C. Clark,Judith Clarke,P Clift,Sara Clohisey,Z Coburn,John B. Cole,C Coleman,D W Connell,B Connolly,Lynda Connor,Angela Cook,Brendan G Cooper,C Coupland,T Craig,P Crisp,D. Cristiano,M G Crooks,A Cross,I Cruz,Paul Cullinan,L Daines,M Dalton,Paul Dark,J. Dasgin,Asaf David,C David,Melanie J. Davies,Gail Davies,Kevin A. Davies,F. Davies,G A Davies,Enya Daynes,T I de Silva,A De Soyza,Bill Deakin,A Deans,S Defres,Anne Dell,K Dempsey,Joe Dennis,A Dewar,R Dharmagunawardena,N Diar Bakerly,A Dipper,S Diver,S N Diwanji,M Dixon,R Djukanovic,H Dobson,C Dobson,S L Dobson,A B Docherty,Andrew Donaldson,T Dong,N. Dormand,A Dougherty,R Dowling,S Drain,P Dulawan,S Dunn,N Easom,C Echevarria,Sebastian Edwards,Charlotte L. Edwardson,B Elliott,Amanda F. Elliott,Y Ellis,A Elmer,O Elneima,R A Evans,Julie Evans,H Evans,David M. Evans,R I Evans,R Evans,Todd Evans,L Fabbri,S Fairbairn,A Fairman,K Fallon,D Faluyi,C Favager,Timothy Felton,Jonathan Finch,S Finney,Helen L. Fisher,Shelley Fletcher,R Flockton,D Foote,A Ford,D Forton,Richard W. Francis,S Francis,C Francis,A Frankel,E Fraser,R Free,N French,J Fuld,James J Furniss,L Garner,Nikki Gautam,J R Geddes,P M George,Jeremy George,M Gibbons,L Gilmour,Fergus V. Gleeson,J Glossop,S Glover,N Goodman,B Gooptu,T. Gorsuch,E Gourlay,P Greenhaff,William Greenhalf,A Greenhalgh,N J Greening,John P Greenwood,S Greenwood,R Gregory,Douglas Grieve,M. Gummadi,Atul Gupta,S Gurram,Ellen Guthrie,K Hadley,A Haggar,K Hainey,P Haldar,I Hall,Lynsey S. Hall,M Halling-Brown,R Hamil,N A Hanley,Hayley Hardwick,Elaine Hardy,B Hargadon,Kyle Harrington,V Harris,E M Harrison,Phil Harrison,N Hart,Alison G. Harvey,Miriam Harvey,M Harvie,M Havinden-Williams,J Hawkes,N Hawkings,J Haworth,A Hayday,L G Heaney,J L Heeney,Melissa Heightman,S Heller,Morag Henderson,L Hesselden,Toby Hillman,Aroon D. Hingorani,T Hiwot,L P Ho,A Hoare,M Hoare,P Hogarth,A Holbourn,L Holdsworth,D Holgate,K Holmes,B Holroyd-Hind,A Horsley,A Hosseini,Matthew Hotopf,L Houchen,Louise M. Howard,A Howell,E Hufton,Alan Hughes,Joseph Hughes,R Hughes,A Humphries,N Huneke,J R Hurst,R Hurst,Mujtaba Husain,T Hussell,W Ibrahim,A Ient,L Ingram,Khalida Ismail,Thomas A Jackson,J Jacob,W Y James,Sam M. Janes,H Jarvis,B Jayaraman,R G Jenkins,Peter Jezzard,K Jiwa,Sonia Johnson,Craig Johnson,D Johnston,C Jolley,C J Jolley,Ifan Jones,S Jones,D Jones,H Jones,Graeme Jones,Margaret Jones,S. Jose,Thomas Kabir,G Kaltsakas,Vicky Kamwa,P Kar,Z Kausar,Siobhan Kelly,S Kerr,A L Key,F Khan,Kamlesh Khunti,C King,B King,P Kitterick,Paul Klenerman,L Knibbs,Stephen R Knight,A Knighton,O M Kon,S Kon,S S Kon,Ania Korszun,Christos P Kotanidis,I Koychev,P Kurupati,J Kwan,C Laing,H Lamlum,Geraldine Landers,Claudia Langenberg,Daniel Lasserson,Alison M. Lawrie,A Lea,O C Leavy,Donghyung Lee,E Lee,K Leitch,R Lenagh,K Lewis,V Lewis,K E Lewis,J Lewis,N Lewis-Burke,Teresa Light,L Lightstone,L Lim,S Linford,A Lingford-Hughes,Marc Lipman,K. Liyanage,A Lloyd,S Logan,David A. Lomas,N I Lone,R. Loosley,J M Lord,H Lota,A Lucey,G MacGowan,I Macharia,Clare E. Mackay,Linda MacLiver,Shyam Madathil,G Madzamba,N Magee,N Mairs,N Majeed,E Major,M Malim,G Mallison,W Man,Swapna Mandal,K Mangion,P Mansoori,S Marciniak,M Mariveles,M Marks,Ben G. Marshall,A Martineau,Nick A Maskell,D Matila,L Matthews,J Mayet,S McAdoo,H McAllister-Williams,P McArdle,A McArdle,D McAulay,H McAuley,Daniel F. McAuley,K McCafferty,G P McCann,H McCauley,P McCourt,L Mcgarvey,J McGinness,A McGovern,H. McGuinness,Iain B. McInnes,K McIvor,E McIvor,Alex D. McMahon,M J McMahon,L. McMorrow,T Mcnally,M McNarry,A McQueen,Helen McShane,S Megson,J Meiring,Donna J. Menzies,A Michael,L Milligan,N Mills,James E. Mitchell,A Mohamed,Philip L. Molyneaux,William Monteiro,A Morley,L Morrison,R Morriss,Ardythe L. Morrow,A Moss,A J Moss,Paul Moss,Elizabeta B. Mukaetova-Ladinska,U Munawar,Elodie Murali,J Murira,H Nassa,P Neill,S Neubauer,David E. Newby,H Newell,A Newton Cox,Timothy R Nicholson,D Nicoll,Claire M. Nolan,M J Noonan,P. Novotny,J Nunag,J Nyaboko,L. O'Brien,N Odell,G Ogg,O Olaosebikan,C Oliver,Z. Omar,Peter J. M. Openshaw,P Rivera-Ortega,R Osbourne,Marlies Ostermann,C Overton,J Oxton,E Pacpaco,S Paddick,Padmasayee Papineni,K Paradowski,M Pareek,D Parekh,H Parfrey,Carmine M. Pariante,Stephen C. J. Parker,Margot W. Parkes,J Parmar,R Parvin,S Patale,Brij Patel,Smitaa Patel,Meenal Patel,B Pathmanathan,Michael Pavlides,J E Pearl,Daniel Peckham,J. Pendlebury,Y Peng,Catherine Pennington,I Peralta,E. Perkins,T Peto,Nayia Petousi,John R. Petrie,P Pfeffer,J Phipps,Jonathan Pimm,K Piper Hanley,R Pius,S Plein,T Plekhanova,K Poinasamy,Oliver Polgar,L Poll,J C Porter,S Portukhay,N Powell,L Price,David Price,Anthony N. Price,C. Price,A Prickett,S. Quaid,J Quigley,Jennifer K Quint,H Qureshi,N Rahman,M Rahman,M Ralser,B Raman,A Ramos,J Rangeley,Tim Rees,K Regan,Alexander Richards,M Richardson,E Robertson,J Rodgers,G Ross,J Rossdale,Anthony J. Rostron,A Routen,A Rowland,M J Rowland,J Rowland,S L Rowland-Jones,K Roy,Igor Rudan,R Russell,E. Russell,R Sabit,E K Sage,Nilesh J. Samani,R Samuel,E Sapey,D Saralaya,A Saratzis,Jack A. Sargeant,T Sass,Naveed Sattar,Kathryn J Saunders,R Saunders,W Saxon,Avan Aihie Sayer,W Schwaeble,Janet T Scott,K Scott,N Selby,Malcolm G Semple,M Sereno,Khalid Shah,A. J. Shah,P Shah,Manu Sharma,Michael Sharpe,C Sharpe,V Shaw,A Sheikh,K Shevket,A Shikotra,Jennifer M. Short,Salman Siddiqui,Louise Sigfrid,G Simons,J Simpson,A Singapuri,S J Singh,C Singh,S Singh,J Skeemer,I Smith,Jennifer A. Smith,Lee B. Smith,Andrew Smith,Marcia Soares,D Southern,M Spears,L G Spencer,F Speranza,Louise Stadon,S Stanel,Michael C Steiner,David J. Stensel,M Stern,Isobel D. Stewart,James Stockley,Richard Kevin Stone,A Storrie,K Storton,E Stringer,Christian P Subbe,Cathie Sudlow,Z Suleiman,Charlotte Summers,C Summersgill,D Sutherland,D L Sykes,Robert Sykes,Nick P. Talbot,A L Tan,Clare J Taylor,Andrew M. Taylor,A Te,H Tedd,C J Tee,H. Tench,S Terry,S Thackray-Nocera,F Thaivalappil,D Thickett,David C. Thomas,D C Thomas,Aliki Thomas,Alfred A.R. Thompson,Teresa Thompson,T Thornton,Ryan S Thwaites,Mark J. Tobin,G F Toingson,C Tong,M Toshner,Rhian M. Touyz,K A Tripp,Elizabeth M. Tunnicliffe,E Turner,L Turtle,H Turton,R Ugwuoke,R Upthegrove,J Valabhji,K Vellore,E Wade,L V Wain,L O Wajero,S Walder,Susan P. Walker,E Wall,T Wallis,S Walmsley,S Walsh,Jill Walsh,L Watson,JM Watson,E. Watson,Carly Welch,H Welch,B. Welsh,Simon Wessely,S West,H Wheeler,V Whitehead,J Whitney,S Whittaker,B Whittam,J Wild,M Wilkins,D Wilkinson,Nicola Williams,Bryan Williams,Julie Williams,S A Williams-Howard,M Willicombe,G Willis,David Wilson,I Wilson,N Window,Miles D. Witham,R. Wolf-Roberts,F Woodhead,J Woods,Daniel G. Wootton,J Worsley,D Wraith,L Wright,C Wright,S Wright,C Xie,S Yasmin,Thomas Yates,K P Yip,B Young,S Young,A Young,A J Yousuf,A Yousuf,A Zawia,B Zhao,O. Zongo +780 more
TL;DR: In this paper, the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes were determined.
Journal ArticleDOI
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Loukia Tsaprouni,Tsun-Po Yang,Jordana T. Bell,Katherine J. Dick,Stavroula Kanoni,James Nisbet,Ana Viñuela,Elin Grundberg,Christopher P. Nelson,Eshwar Meduri,Alfonso Buil,François Cambien,Christian Hengstenberg,Jeanette Erdmann,Heribert Schunkert,Alison H. Goodall,Willem H. Ouwehand,Emmanouil T. Dermitzakis,Tim D. Spector,Nilesh J. Samani,Panos Deloukas +20 more
TL;DR: The findings suggest the existence of dynamic, reversible site-specific methylation changes in response to cigarette smoking, which may contribute to the extended health risks associated with cigarette smoking.
Journal ArticleDOI
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
Xiangfeng Lu,Laiyuan Wang,Laiyuan Wang,Shufeng Chen,Lin He,Xueli Yang,Yongyong Shi,Jing Cheng,Lei Zhang,C. Charles Gu,Jianfeng Huang,Tangchun Wu,Yitong Ma,Jianxin Li,Jie Cao,Jichun Chen,Dongliang Ge,Zhongjie Fan,Ying Li,Liancheng Zhao,Hongfan Li,Xiaoyang Zhou,Lanying Chen,Donghua Liu,Jingping Chen,Xiufang Duan,Yongchen Hao,Ligui Wang,Fanghong Lu,Zhendong Liu,Cailiang Yao,Chong Shen,Xiaodong Pu,Lin Yu,Xianghua Fang,Lihua Xu,Jianjun Mu,Xian-Ping Wu,Runping Zheng,Naqiong Wu,Qi Zhao,Yun Li,Xiaoli Liu,Mengqin Wang,Dahai Yu,Dongsheng Hu,Dongsheng Hu,Xu Ji,Dongshuang Guo,Dongling Sun,Qianqian Wang,Ying Yang,Fangchao Liu,Qunxia Mao,Xiao-hua Liang,Jingfeng Ji,Panpan Chen,Xing-Bo Mo,Dianjiang Li,Guoping Chai,Yida Tang,Xiangdong Li,Zhenhan Du,Xuehui Liu,Chenlong Dou,Zili Yang,Qingjie Meng,Dong Wang,Renping Wang,Jun Yang,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Sekar Kathiresan,Sekar Kathiresan,Muredach P. Reilly,Jeanette Erdmann,Xiaozhong Peng,Xigui Wu,De-Pei Liu,Yuejin Yang,Runsheng Chen,Boqin Qiang,Dongfeng Gu +83 more
TL;DR: A meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls provides new insights into pathways contributing to the susceptibility for coronary arteries disease in the Chinese Han population.
Journal ArticleDOI
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Matthias Heinig,Enrico Petretto,Chris Wallace,Leonardo Bottolo,Maxime Rotival,Han Lu,Yoyo Li,Rizwan Sarwar,Sarah R. Langley,Anja Bauerfeind,Oliver Hummel,Young-Ae Lee,Young-Ae Lee,Svetlana Paskas,Carola Rintisch,Kathrin Saar,Jason D. Cooper,Rachel Buchan,Elizabeth E. Gray,Jason G. Cyster,Jeanette Erdmann,Christian Hengstenberg,Seraya Maouche,Willem H. Ouwehand,Willem H. Ouwehand,Catherine M. Rice,Nilesh J. Samani,Heribert Schunkert,Alison H. Goodall,Herbert Schulz,Helge G. Roider,Martin Vingron,Stefan Blankenberg,Thomas Münzel,Tanja Zeller,Silke Szymczak,Andreas Ziegler,Laurence Tiret,Deborah J. Smyth,Michal Pravenec,Timothy J. Aitman,François Cambien,David Clayton,John A. Todd,Norbert Hubner,Norbert Hubner,Stuart A. Cook,Stuart A. Cook +47 more
TL;DR: The use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D.
Journal ArticleDOI
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
Nathan O. Stitziel,Amit Khera,Xiao Wang,Andrew J. Bierhals,A. Christina Vourakis,Alexandra E Sperry,Pradeep Natarajan,Derek Klarin,Connor A. Emdin,Seyedeh M. Zekavat,Akihiro Nomura,Jeanette Erdmann,Heribert Schunkert,Nilesh J. Samani,William E. Kraus,Svati H. Shah,Bing Yu,Eric Boerwinkle,Daniel J. Rader,Namrata Gupta,Philippe M. Frossard,Asif Rasheed,John Danesh,Eric S. Lander,Stacey Gabriel,Danish Saleheen,Kiran Musunuru,Sekar Kathiresan,Promis +28 more
TL;DR: ANGPTL3 deficiency is associated with protection from CAD, and individuals in the lowest tertile of circulating ANGPTL 3 concentrations, compared with the highest, had reduced odds of MI.