Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Context (language use) & Machine translation. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

Metallic tube type energy absorbers: A synopsis

Abstract: This paper presents an overview of energy absorbers in the form of tubes in which the material used is predominantly mild steel and/or aluminium. A brief summary is also given of frusta type energy absorbers. The common modes of deformation such as lateral and axial compression, indentation and inversion are reviewed. Theoretical, numerical and experimental methods which help to understand the behaviour of such devices under various loading conditions are outlined. Although other forms of energy absorbing materials and structures exist such as composites and honeycombs, it is deemed outside the scope of this review. Nonetheless, a brief description will be given on these materials. It is hoped that this article will provide a useful platform for researchers and design engineers to gain a useful insight into the progress made over the last few decades in the field of tube type energy absorbers.

Fasciola hepatica infection downregulates Th1 responses in mice

Abstract: SUMMARY Immune responses induced with helminth parasites have been extensively studied, but there is limited information on those to Fasciola hepatica, especially on the subtype of T cell induced with this parasite. We investigated the local and systemic Tcell responses of different strains of mice following oral infection with doses of metacercariae fromF. hepatica. Spleen cells from BALB/c and 129Sv/Ev mice given a low-dose (5 metacercariae) infection exhibited a Th2 response, producing high levels of the cytokines IL-4 and IL-5, and low levels of IFN- g and IL-2. In contrast, C57BL/6 mice showed a mixed Th1/Th2 response. A more marked polarization to a Th2 response was observed in BALB/c, 129Sv/Ev exposed to a high-dose (15 metacercariae) infection and the C57BL/6 mice also exhibited a clear Th2 response. IL-4 defective (IL-4 π/π ) C57BL/6 mice infected with 5 metacercariae produced less IFN- g and more IL-5 compared to their wild-type C57BL/6 counterparts, suggesting that IL-4 is important in establishing the Th2 type response in murine fasciolosis. However, the secretion of IFN-g and IL-2 was completely suppressed in the high-dose infection and this was also observed in IL-4 π/π mice. Thus, liver flukes may secrete molecules that downregulate Th1 responses. T cell responses in the mesenteric (MLN) and hepatic lymph nodes (HLN) were also examined since newly excysted juveniles infect through the intestinal wall of their host before migrating to the hepatic tissue. Cells from both MLN and HLN secreted higher levels of IL-4 and IL-5 compared to spleen cells. We also observed a difference in cytokine profiles secreted by the MLN and HLN, which may reflect responses to antigens liberated by newly excysted juveniles and hepatic stage parasites, respectively.

Aberrant PSA glycosylation—a sweet predictor of prostate cancer

Abstract: Prostate cancer--the most commonly diagnosed cancer in men worldwide--can have a substantial effect on quality of life, regardless of the route the cancer takes. The serum PSA assay is the current gold standard option for diagnosing prostate cancer. However, a growing body of evidence suggests that PSA screening for prostate cancer results in extensive overdiagnosis and overtreatment. It is increasingly evident that the potential harm from overdiagnosis (in terms of unnecessary biopsies) must be weighed against the benefit derived from the early detection and treatment of potentially fatal prostate cancers. Rapid screening methods have been used to analyse glycosylation patterns on glycoproteins in large cohorts of patients, enabling the identification of a new generation of disease biomarkers. Changes to the expression status of certain glycan structures are now widely thought to be common features of tumour progression. In light of this development, much research has focused on the potential role of altered PSA glycosylation patterns in discriminating between significant and insignificant prostate cancers, with the aim of developing a more reliable diagnostic tool than the current serum PSA test.