Dublin City University

About: Dublin City University is a education organization based out in Dublin, Ireland. It is known for research contribution in the topics: Context (language use) & Machine translation. The organization has 5904 authors who have published 17178 publications receiving 389376 citations. The organization is also known as: National Institute for Higher Education, Dublin & DCU.

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group

Abstract: The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.

Presence of oxygen and aerobic communities from sea floor to basement in deep-sea sediments

Abstract: The depth of oxygen penetration and microbial activity in marine sediments varies by region. Sediment cores from the South Pacific Gyre host oxygen and aerobic microbial communities to at least 75 metres below the sea floor.

Host Students' Perspectives of Intercultural Contact in an Irish University

Abstract: Given the increasing numbers of international students in Ireland and the lack of attention afforded to host culture students in existing research on intercultural relations in higher education, a grounded theory study was conducted in an Irish university exploring host (Irish) students' perspectives on intercultural contact. The study focused on students' construction of cultural difference within the educational environment, the factors influencing intercultural contact, and students' experiences of such contact. The findings suggest that although nationality and age are used to differentiate students, the concept of “maturity”—underpinned by values and behaviors relating to academic motivations, responsibilities, and authority—is central to students' construction of cultural difference on campus.Diverse factors identified as impacting upon students' intercultural acquaintance prospects and relational development are presented and discussed. The findings highlight the complexity of promoting meaningful ...

Socio-economic determinants of physical activity across the life course: A "DEterminants of DIet and Physical ACtivity" (DEDIPAC) umbrella literature review

Abstract: Background To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (eg education or parental income) in one specific age group (eg pre-school children or adults) The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course Methods Medline, Embase, ISI Web of Science, Scopus and SPORTDiscus were searched for systematic literature reviews and meta-analyses of observational studies investigating the association between socioeconomic determinants of PA and PA itself (from January 2004 to September 2017) Data extraction evaluated the importance of determinants, strength of evidence, and methodological quality of the selected papers The full protocol is available from PROSPERO (PROSPERO2014:CRD42015010616) Results Nineteen reviews were included Moderate methodological quality emerged For adults, convincing evidence supports a relationship between PA and socioeconomic status (SES), especially in relation to leisure time (positive relationship) and occupational PA (negative relationship) Conversely, no association between PA and SES or parental SES was found for pre-school, school-aged children and adolescents Conclusions Available evidence on the socioeconomic determinants of PA behaviour across the life course is probable (shows fairly consistent associations) at best While some evidence is available for adults, less was available for youth This is mainly due to a limited quantity of primary studies, weak research designs and lack of accuracy in the PA and SES assessment methods employed Further PA domain specific studies using longitudinal design and clear measures of SES and PA assessment are required