Institution
Swedish University of Agricultural Sciences
Education•Uppsala, Sweden•
About: Swedish University of Agricultural Sciences is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Soil water. The organization has 13510 authors who have published 35241 publications receiving 1414458 citations. The organization is also known as: Sveriges Lantbruksuniversitet & SLU.
Topics: Population, Soil water, Species richness, Biodiversity, Gene
Papers published on a yearly basis
Papers
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TL;DR: The results reveal that molecular chaperones can help maintain protein homeostasis by selectively suppressing critical microscopic steps within the complex reaction pathways responsible for the toxic effects of protein misfolding and aggregation.
Abstract: Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces effectively catalyze the formation of neurotoxic oligomers. Here we show that a molecular chaperone, a human Brichos domain, can specifically inhibit this catalytic cycle and limit human Aβ42 toxicity. We demonstrate in vitro that Brichos achieves this inhibition by binding to the surfaces of fibrils, thereby redirecting the aggregation reaction to a pathway that involves minimal formation of toxic oligomeric intermediates. We verify that this mechanism occurs in living mouse brain tissue by cytotoxicity and electrophysiology experiments. These results reveal that molecular chaperones can help maintain protein homeostasis by selectively suppressing critical microscopic steps within the complex reaction pathways responsible for the toxic effects of protein misfolding and aggregation.
329 citations
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TL;DR: It is recommended that mice should have access to nesting material in cages for mice, in which preferences as well as the effect of housing modifications have been studied.
Abstract: Summary Laboratory animal facilities have been designed to provide a standard environment where animals can be kept in good physical health at the same time as economic and ergonomic considerations are met. Recognizing the potential welfare problem associated with behavioural restriction in such housing systems, a number of attempts have been made to improve this environment, generally described under the termenvironmental enrichment'. Modi® cations of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and =or for climbing. We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modi® cations have been studied. Mice will work for access to nesting material and make use of this material to make nests in which they rest. They prefer a more complex cage to the standard cage and will also work for access to cages with shelter and raised platforms. On the basis of present knowledge, it is recommended that mice should have access to nesting material. Strategies for future research are outlined in the article.
329 citations
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TL;DR: A key role for mast cell chymase is indicated in the regulation of pro-MMP-2 and -9 activities and the results suggest an important role in regulating connective tissue homeostasis.
328 citations
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TL;DR: It is suggested that above-ground pho- tosynthetic activity and allocation patterns of recent phos- tosynthates to roots should be considered in models of responses of forest C balances to global climate change.
Abstract: Limitations in available techniques to separate autotrophic (root) and soil heterotrophic respiration have hampered the understanding of forest C cycling. The former is here defined as respiration by roots, their associated mycorrhizal fungi and other micro-organisms in the rhizosphere directly dependent on labile C compounds leaked from roots. In order to separate the autotrophic and heterotrophic com- ponents of soil respiration, all Scots pine trees in 900 m 2 plots were girdled to instantaneously terminate the supply of current photosynthates from the tree canopy to roots. Hogberg et al . ( Nature 411, 789-792, 2001) reported that autotrophic activity contributed up to 56% of total soil respiration during the first summer of this experiment. They also found that mobilization of stored starch (and likely also sugars) in roots after girdling caused an increased apparent heterotrophic respiration on girdled plots. Herein a transient increase in the d 13 C of soil CO 2 efflux after girdling, thought to be due to decomposition of 13 C- enriched ectomycorrhizal mycelium and root starch and sugar reserves, is reported. In the second year after girdling, when starch reserves of girdled tree roots were exhausted, calculated root respiration increased up to 65% of total soil CO 2 efflux. It is suggested that this estimate of its contribu- tion to soil respiration is more precise than the previous based on one year of observation. Heterotrophic respira- tion declined in response to a 20-day-long 6 ∞ C decline in soil temperature during the second summer, whereas root respiration did not decline. This did not support the idea that root respiration should be more sensitive to variations in soil temperature. It is suggested that above-ground pho- tosynthetic activity and allocation patterns of recent pho- tosynthates to roots should be considered in models of responses of forest C balances to global climate change.
328 citations
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Complutense University of Madrid1, Natural History Museum2, Centraalbureau voor Schimmelcultures3, University of California, Berkeley4, University of Pretoria5, Ege University6, Louisiana State University7, Trakya University8, Ruhr University Bochum9, Anadolu University10, Landcare Research11, Murdoch University12, Medical University of Graz13, Royal Botanic Gardens14, University of Sydney15, Université catholique de Louvain16, Vienna University of Technology17, University of Nottingham18, University of Miami19, Technical University of Denmark20, Pennsylvania State University21, Leiden University22, Federal University of Paraná23, Canadian Grain Commission24, Wageningen University and Research Centre25, Clark University26, National Academy of Agricultural Sciences27, Field Museum of Natural History28, Istanbul University29, CABI30, University of Tartu31, United States Department of Agriculture32, University of Illinois at Urbana–Champaign33, Mashhad University of Medical Sciences34, Russian Academy of Sciences35, Swedish University of Agricultural Sciences36, Celal Bayar University37, Goethe University Frankfurt38, University of Szeged39, University of Antioquia40
TL;DR: The Amsterdam Declaration on Fungal Nomenclature recognizes the need for an orderly transitition to a single-name nomenclatural system for all fungi, and to provide mechanisms to protect names that otherwise then become endangered.
Abstract: The Amsterdam Declaration on Fungal Nomenclature was agreed at an international symposium convened in Amsterdam on 19–20 April 2011 under the auspices of the International Commission on the Taxonomy of Fungi (ICTF). The purpose of the symposium was to address the issue of whether or how the current system of naming pleomorphic fungi should be maintained or changed now that molecular data are routinely available. The issue is urgent as mycologists currently follow different practices, and no consensus was achieved by a Special Committee appointed in 2005 by the International Botanical Congress to advise on the problem. The Declaration recognizes the need for an orderly transitition to a single-name nomenclatural system for all fungi, and to provide mechanisms to protect names that otherwise then become endangered. That is, meaning that priority should be given to the first described name, except where that is a younger name in general use when the first author to select a name of a pleomorphic monophyletic genus is to be followed, and suggests controversial cases are referred to a body, such as the ICTF, which will report to the Committee for Fungi. If appropriate, the ICTF could be mandated to promote the implementation of the Declaration. In addition, but not forming part of the Declaration, are reports of discussions held during the symposium on the governance of the nomenclature of fungi, and the naming of fungi known only from an environmental nucleic acid sequence in particular. Possible amendments to the Draft BioCode (2011) to allow for the needs of mycologists are suggested for further consideration, and a possible example of how a fungus only known from the environment might be described is presented.
328 citations
Authors
Showing all 13653 results
Name | H-index | Papers | Citations |
---|---|---|---|
Svante Pääbo | 147 | 407 | 84489 |
Lars Klareskog | 131 | 697 | 63281 |
Stephen Hillier | 129 | 1138 | 83831 |
Carol V. Robinson | 123 | 670 | 51896 |
Jun Yu | 121 | 1174 | 81186 |
Peter J. Anderson | 120 | 966 | 63635 |
David E. Clapham | 119 | 382 | 58360 |
Angela M. Gronenborn | 113 | 568 | 44800 |
David A. Wardle | 110 | 409 | 70547 |
Agneta Oskarsson | 106 | 766 | 40524 |
Jack S. Remington | 103 | 481 | 38006 |
Hans Ellegren | 102 | 349 | 39437 |
Per A. Peterson | 102 | 356 | 35788 |
Malcolm J. Bennett | 99 | 439 | 37207 |
Gunnar E. Carlsson | 98 | 466 | 32638 |