Institution
Swedish University of Agricultural Sciences
Education•Uppsala, Sweden•
About: Swedish University of Agricultural Sciences is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Soil water. The organization has 13510 authors who have published 35241 publications receiving 1414458 citations. The organization is also known as: Sveriges Lantbruksuniversitet & SLU.
Topics: Population, Soil water, Species richness, Biodiversity, Gene
Papers published on a yearly basis
Papers
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TL;DR: When the genome sequences of domestic animals become available the identification of the mutations that underlie the transformation from a wild to a domestic species will be a realistic and important target.
Abstract: One of the 'grand challenges' in modern biology is to understand the genetic basis of phenotypic diversity within and among species. Thousands of years of selective breeding of domestic animals has created a diversity of phenotypes among breeds that is only matched by that observed among species in nature. Domestic animals therefore constitute a unique resource for understanding the genetic basis of phenotypic variation. When the genome sequences of domestic animals become available the identification of the mutations that underlie the transformation from a wild to a domestic species will be a realistic and important target.
538 citations
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TL;DR: In this article, the economic rationale for the spike models and their estimation techniques are discussed, and empirical illustrations are provided, which have some bearing on the continuing debate of the incentive properties of hypothetical surveys and the construction of scenarios in contingent valuation experiments.
Abstract: Spike models allow for a nonzero probability of zero willingness to pay in referendum-style contingent valuation experiments. They include many of the often used models as special cases and allow various analyses that are not possible in standard applications. In this paper, the economic rationale for the spike models and their estimation techniques are discussed, and empirical illustrations are provided. One study suggests that mean willingness to pay is zero, and both studies strongly suggest that median WTP is zero. These results have some bearing on the continuing debate of the incentive properties of hypothetical surveys and the construction of scenarios in contingent valuation experiments.
538 citations
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TL;DR: The association of mtDNA depletion with mutated DGUOK suggests that the salvage-pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
Abstract: Mitochondrial DNA (mtDNA)-depletion syndromes (MDS; OMIM 251880) are phenotypically heterogeneous, autosomal-recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of MDS have early progressive liver failure and neurological abnormalities, hypoglycemia and increased lactate in body fluids. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes (I, III, IV, V) and mtDNA depletion. We used homozygosity mapping in three kindreds of Druze origin to map the gene causing hepatocerebral MDS to a region of 6.1 cM on chromosome 2p13, between markers D2S291 and D2S2116. This interval encompasses the gene (DGUOK) encoding the mitochondrial deoxyguanosine kinase (dGK). We identified a single-nucleotide deletion (204delA) within the coding region of DGUOK that segregates with the disease in the three kindreds studied. Western-blot analysis did not detect dGK protein in the liver of affected individuals. The main supply of deoxyribonucleotides (dNTPs) for mtDNA synthesis comes from the salvage pathway initiated by dGK and thymidine kinase-2 (TK2). The association of mtDNA depletion with mutated DGUOK suggests that the salvage-pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
538 citations
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TL;DR: Necrotic and late apoptotic cells release material that, combined with SLE IgG, induces production of IFN alpha in PDCs, and the presence of Sle IgG was necessary, and its activity correlated with the existence of antibodies to RNA-binding proteins, but not anti-DNA antibodies.
Abstract: Objective
To investigate the release of interferon-α (IFNα)–inducing material by necrotic or apoptotic cells, its properties, and the necessity of autoantibodies from systemic lupus erythematosus (SLE) patients for the interferogenic activity.
Methods
U937 monocytic leukemia cells or peripheral blood mononuclear cells (PBMCs) were rendered necrotic by freeze-thawing or apoptotic by treatment with ultraviolet light. Cell culture supernatants from these cells and IgG from SLE patients (SLE IgG) were added to cultures of normal PBMCs or purified plasmacytoid dendritic cells (PDCs). The importance of nucleic acids for IFNα induction was investigated by RNase and DNase treatment. The IFNα levels were measured by immunoassay.
Results
Both necrotic and apoptotic U937 cells released material that, combined with SLE IgG, induced IFNα production in PDCs. The release from apoptotic cells occurred with a 16-hour delay, in late apoptosis. Also, normal PBMCs released IFNα-inducing material, but only during necrosis. The interferogenic activity of the necrotic material required the presence of RNA, while both RNA and DNA were important in the apoptotic material. In both cases, the presence of SLE IgG was necessary, and its activity correlated with the presence of antibodies to RNA-binding proteins, but not anti-DNA antibodies.
Conclusion
Necrotic and late apoptotic cells release material that, combined with SLE IgG, induces production of IFNα in PDCs. The IFNα inducers probably consist of immune complexes (ICs) containing RNA and possibly DNA as essential interferogenic components. The presence of such interferogenic ICs could explain the ongoing production of IFNα in SLE and could be of etiopathogenic importance.
536 citations
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Commonwealth Scientific and Industrial Research Organisation1, University of Tübingen2, Tel Aviv University3, Washington State University4, University of São Paulo5, World Agroforestry Centre6, Zhejiang University7, Swedish University of Agricultural Sciences8, Université catholique de Louvain9, McGill University10, SupAgro11, Wageningen University and Research Centre12, Karlsruhe Institute of Technology13, Finnish Environment Institute14, Czech University of Life Sciences Prague15, Chinese Academy of Sciences16, Agrocampus Ouest17, Gembloux Agro-Bio Tech18, University of Florida19, Universidad Miguel Hernández de Elche20, Landcare Research21, Aarhus University22, International Trademark Association23, University of Northern British Columbia24, University of Molise25, Agricultural Research Service26, British Geological Survey27, Rural Development Administration28
TL;DR: In this article, the authors developed and analyzed a global soil visible-near infrared (vis-NIR) spectral library, which is currently the largest and most diverse database of its kind, and showed that the information encoded in the spectra can describe soil composition and be associated to land cover and its global geographic distribution, which acts as a surrogate for global climate variability.
535 citations
Authors
Showing all 13653 results
Name | H-index | Papers | Citations |
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Svante Pääbo | 147 | 407 | 84489 |
Lars Klareskog | 131 | 697 | 63281 |
Stephen Hillier | 129 | 1138 | 83831 |
Carol V. Robinson | 123 | 670 | 51896 |
Jun Yu | 121 | 1174 | 81186 |
Peter J. Anderson | 120 | 966 | 63635 |
David E. Clapham | 119 | 382 | 58360 |
Angela M. Gronenborn | 113 | 568 | 44800 |
David A. Wardle | 110 | 409 | 70547 |
Agneta Oskarsson | 106 | 766 | 40524 |
Jack S. Remington | 103 | 481 | 38006 |
Hans Ellegren | 102 | 349 | 39437 |
Per A. Peterson | 102 | 356 | 35788 |
Malcolm J. Bennett | 99 | 439 | 37207 |
Gunnar E. Carlsson | 98 | 466 | 32638 |