Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Psychomotor retardation in depression: A critical measure of the forced swim test.
Gunes Unal,Resit Canbeyli +1 more
TL;DR: The clinical significance and neurobiology of psychomotor retardation is discussed, and how FST, measuring this mechanical aspect of the disease, emerges as a reliable method and a critical step in antidepressant research is evaluated.
Journal ArticleDOI
Quantitative proteomics analysis of the liver reveals immune regulation and lipid metabolism dysregulation in a mouse model of depression.
You Wu,Jianyong Tang,Chanjuan Zhou,Libo Zhao,Jin Chen,Li Zeng,Chenglong Rao,Haiyang Shi,Li Liao,Zihong Liang,Yongtao Yang,Jian Zhou,Peng Xie +12 more
TL;DR: The liver protein expression profile in the CUMS mouse model of depression is reported, for the first time, to provide novel insight into the multifaceted mechanisms of major depressive disorder.
Journal ArticleDOI
Brain Part Monoamines in the Neuroendocrine Mechanisms Activated by Immobilization Stress in the Rat
TL;DR: The hypothesis that ACTH release is stimulated by serotonergic neural activity is supported, as rats given both neurotoxins were sacrificed and plasma corticosterone and brain part monoamines were measured.
Journal ArticleDOI
Antidepressant, Myorelaxant and Anti-Anxiety-Like Effects of Nauclea latifolia Smith (Rubiaceae) Roots Extract in Murine Models
Germain Sotoing Taiwe,E. Ngo Bum,Théophile Dimo,Emmanuel Talla,Norbert Weiss,Amadou Dawe,Fleur Clarisse Okomolo Moto,Neteydji Sidiki,Paul Désiré Djomeni Dzeufiet,M. de Waard +9 more
TL;DR: The results suggest that Nauclea latifolia roots decoction possess antidepressant, myorelaxant and anti-anxiety-like properties in the models employed.
Journal ArticleDOI
A comparison of drug effects in latent inhibition and the forced swim test differentiates between the typical antipsychotic haloperidol, the atypical antipsychotics clozapine and olanzapine, and the antidepressants imipramine and paroxetine.
TL;DR: Comparison of drug effects in LI and FST enabled a discrimination between typical and atypical APDs without losing selectivity for APDs.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more