Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants.
TL;DR: This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
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The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.
TL;DR: The tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression.
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The validity of animal models of depression.
TL;DR: The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
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Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
TL;DR: The evidence supports the hypothesis that under certain circumstances rats can become sugar dependent and may translate to some human conditions as suggested by the literature on eating disorders and obesity.
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The spectrum of behaviors influenced by serotonin
TL;DR: The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior.
References
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Journal ArticleDOI
Effect of iprindole on amine uptake in man.
William E. Fann,John M. Davis,David S. Janowsky,John S. Kaufmann,John D. Griffith,John A. Oates +5 more
TL;DR: Findings call into question that aspect of the biogenic amine theory of depression which states that the tricyclic drugs exert their antidepressant action by inhibiting the membrane pump.
Journal ArticleDOI
Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities.
Lippman W,Pugsley Ta +1 more
TL;DR: Viloxazine exhibits activities related to the biogenic amines both similar to and different from the tricyclics desimipramines, imipramine, and amitriptyline, which appear to be of relevance with respect to the antidepressant action of this drug.
Journal ArticleDOI
Mianserin versus amitriptyline. A double-blind-trial evaluated by the AMP system.
Vogel Hp,Bente D,Feder J,Helmchen H,Müller-Oerlinghausen B,Bohacek N,Mihovilovic M,Brändli A,Fleischhauer J,Walcher W +9 more
TL;DR: Most of the depressive symptoms were influenced by both drugs, though quantitative and qualitative differences became evident, and Amitriptyline was particularly effective in psychomotor inhibition and the reduction of vegitative complaints.
Journal ArticleDOI
Iprindole and Imipramine in Non-Psychotic Depressed Out-Patients
TL;DR: Iprindole was found to produce significantly greater improvement than placebo on a variety of outcome measures.
Journal ArticleDOI
A Comparative Clinical Trial of Org GB 94 and Imipramine in the Treatment of Depression in General Practice
TL;DR: Although no statistically significant differences emerged, with regard to both therapeutic effect and some side-effects a trend in favour of Org GB 94 was apparent.
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