Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Journal ArticleDOI
Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female Depression.
Olivia Tania Hernández-Hernández,Lucía Martínez-Mota,José Jaime Herrera-Pérez,Graciela Jiménez-Rubio +3 more
TL;DR: Estradiol increases tryptophan hydroxylase-2 and serotonin transporter expression and decreases the expres-sion of serotonin 1A receptor and monoamine oxidase A and B through the interaction with its intracellular receptors.
Journal ArticleDOI
Escitalopram reduces circulating pro-inflammatory cytokines and improves depressive behavior without affecting sleep in a rat model of post-cardiac infarct depression
Thierno Madjou Bah,Mohamed Benderdour,Sévan Kaloustian,Ramy Karam,Guy Rousseau,Roger Godbout +5 more
TL;DR: In MI rats, behavioral despair and anhedonia were blocked by escitalopram but prolonged sleep latency, low total sleep time and short latency to paradoxical sleep (PS) were not; escITALopram decreased PS in sham controls.
Journal ArticleDOI
Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties.
TL;DR: The present data indicate that the process of kindling is associated with an upregulation of hippocampal BDNF and NPY mRNA levels and downregulation of Y1- and particularly Y5-like receptors, which may have implications for the antiepileptic properties of levetiracetam, as well as its purported mood-stabilizing properties.
Journal ArticleDOI
Acute reversible inactivation of the ventral medial prefrontal cortex induces antidepressant-like effects in rats
América A. Scopinho,Michele Scopinho,S.F. Lisboa,Fernando M.A. Correa,Francisco Silveira Guimarães,Sâmia R.L. Joca +5 more
TL;DR: Results suggest that activation of the vMPFC is important for the behavioral changes observed in rats submitted to the FST, and indicate that, although both the PL and IL cortices are involved in these effects, they may play different roles.
Journal ArticleDOI
Concentration-dependent behavioral changes in mice following short-term inhalation exposure to various industrial solvents
TL;DR: The possibility of using such experimental data as tentative guidelines for setting safe levels of work exposure to the neurotoxicants was suggested, considering the existence of quantitative relationships between the ID50 values and the current occupational standards.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more