Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.
Millan Mark,Adrian Newman-Tancredi,Jean-Michel Rivet,Mauricette Brocco,Pierre Lacroix,Valérie Audinot,Laetitia Cistarelli,Alain P. Gobert +7 more
TL;DR: S 15535 is a selective ligand of cloned, h5-HT1A receptors, and its agonist actions at 5- HT1A autoreceptors underlie its ability to decrease extracellular levels of 5-HT in the FCX, and likely contribute to the increase in extrace cellular levels of DA and NAD evoked by S 15535 in this structure.
Journal ArticleDOI
Animal Models of Negative Symptoms: M100907 Antagonizes PCP-Induced Immobility in a Forced Swim Test in Mice
TL;DR: M100907 may have a unique ability to alleviate the negative symptoms of schizophrenia without the side effects of current antipsychotic medication, and the chronic mild stress model of anhedonia may also be predictive for compounds with efficacy for negative symptoms.
Journal ArticleDOI
Anxiolytic-like actions of leaves of Casimiroa edulis (Rutaceae) in male Wistar rats
Miguel Molina-Hernández,N.P. Tellez-Alcántara,J Pérez Garcı́a,J. I. Olivera Lopez,M. Teresa Jaramillo +4 more
TL;DR: The leaves of Casimiroa edulis (Rutaceae) produced anxiolytic-like actions in male Wistar rats, with several side actions, namely, reduced locomotion and neutralization of the antidepressant- like actions of desipramine.
Journal ArticleDOI
In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice.
Mariana Freire Barbieri Gerzson,Francine N. Victoria,Cátia S. Radatz,Marcelo Gomes de Gomes,Silvana Peterini Boeira,Raquel G. Jacob,Diego Alves,Cristiano Ricardo Jesse,Lucielli Savegnago +8 more
TL;DR: The results suggest that PSAP possesses antioxidant and antidepressant-like properties and may be of interest as a therapeutic agent for the treatment of depressive disorders.
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Changes in the brain expression of alpha-2 subunits of the GABA-A receptor after chronic restraint stress in low- and high-anxiety rats.
Aleksandra Wisłowska-Stanek,Małgorzata Lehner,Anna Skórzewska,Paweł Krząścik,Piotr Maciejak,Janusz Szyndler,Andrzej Ziemba,Adam Płaźnik +7 more
TL;DR: In HR rats exposed to chronic restraint stress, the function of hippocampal and cortical GABAergic neurotransmission is attenuated and that this effect could have important influences on the functioning of the hypothalamic-pituitary-adrenal axis and on depressive symptoms.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more