Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Induction of depressive-like behavior by intranigral 6-OHDA is directly correlated with deficits in striatal dopamine and hippocampal serotonin
Ronise M. Santiago,Janaína K. Barbiero,Raisa W. Gradowski,Suelen Bochen,Marcelo M.S. Lima,Claudio Da Cunha,Roberto Andreatini,Maria A.B.F. Vital +7 more
TL;DR: DA depletion promoted by the neurotoxin 6-hydroxydopamine (6-OHDA) is able to induce depressive-like behavior and neurotransmitter alterations that are similar to those observed in PD, and correlations were found between 5-HT and DA levels and swimming, immobility, and sucrose preference.
Journal ArticleDOI
Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
José Martínez-Clemente,Raúl López-Arnau,Sonia Abad,David Pubill,Elena Escubedo,Jorge Camarasa +5 more
TL;DR: In cultured cortical neurons, mephedrone induced a concentration-dependent cytotoxic effect and evidenced a loss of frontal cortex dopaminergic and hippocampal serotoninergic neuronal markers that suggest injuries at nerve endings.
Journal ArticleDOI
Animal model of depression: tests of three structurally and pharmacologically novel antidepressant compounds.
Richard J. Katz,Michael Sibel +1 more
TL;DR: It is argued that the chronic stress model provides an accurate and selective assessment of the therapeutic potential of both standard and structurally novel compounds.
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The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis
Andrea Navarria,Alessandra Tamburella,Fabio Arturo Iannotti,Vincenzo Micale,Giovanni Camillieri,Lucia Gozzo,Roberta Verde,Roberta Imperatore,Gian Marco Leggio,Filippo Drago,Vincenzo Di Marzo +10 more
TL;DR: Data show that AA-5-HT reverses the rat behavioral despair in the forced swim test under stress conditions, and this effect is associated with the normalization of the HPA-axis deregulation that follows stress application and only in part with elevation of anandamide levels.
Journal ArticleDOI
Repeated weekly exposure to MDMA, methamphetamine or their combination : Long-term behavioural and neurochemical effects in rats
TL;DR: Although chronic, intermittent exposure to MDMA, METH or their combination, may not lead to significant long-term monoamine depletion, lasting adverse behavioural effects may persist, especially those related to social behaviour.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more