Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug
TL;DR: Receptor binding studies revealed that flesinoxan potently and selectively binds to the 5‐HT1A receptor (Ki = 1.7 nM).
Journal ArticleDOI
GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression.
TL;DR: The impairment of GABAergic neurons in the nucleus accumbens is associated with major depression and the invulnerability of neurons to chronic stress may be one of cellular mechanisms for the resilience to Chronic stress.
Journal ArticleDOI
Effect of repeated treatment with desipramine in the behavioral “despair” test in rats: Antagonism by “atypical” but not “classical” neuroleptics or antiadrenergic drugs
TL;DR: The data suggest that a particular subtype of dopamine receptors is involved in the anti-immobility effect of a 7-day treatment with DMI in the behavioral "despair" test in rats.
Journal ArticleDOI
Effect of potassium channel modulators in mouse forced swimming test
TL;DR: Results suggest that modulation of potassium channels plays an important role in the regulation of immobility time in the mouse forced swimming test, and that potassium channels modulators and the mKv1.c.1 aODN did not impair motor coordination, as revealed by the rota rod test.
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IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions.
Tung-Huan Wu,Chih-Hung Lin +1 more
TL;DR: The results show that the immobile behavior of rats in the FST could be modulated by IL-6 via the amygdala or the hippocampus, and the Erk1/2 activation in the amygdala or hippocampus seemed to play a role in the IL- 6 mediated immobile behavioural alterations of rats on the day of the forced swim test.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more