Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae)
TL;DR: The antinociceptive effects of the H. caprifoliatum methanol and H. polyanthemum hexane extracts seem to be mediated by the opioid system, and seems to depend on at least two chemical substances with distinct pharmacokinetic profiles and mechanisms of action.
Journal ArticleDOI
Novel arylsulfonamide derivatives with 5‑HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia
Marcin Kołaczkowski,Monika Marcinkowska,Adam Bucki,Maciej Pawłowski,Katarzyna Mitka,Jolanta Jaśkowska,Piotr A. Kowalski,Grzegorz Kazek,Agata Siwek,Anna Wasik,Anna Wesołowska,Paweł Mierzejewski,Przemyslaw Bienkowski +12 more
TL;DR: Novel multifunctional arylsulfonamide derivatives that potently antagonize 5-HT(6/7/2A) and D2 receptors, without interacting with M1 receptors and hERG channels are obtained to target behavioral and psychological symptoms of dementia.
Journal ArticleDOI
Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.
Kazufumi Hirano,Thomas M. Piers,Kirsten L. Searle,Neil Derek Miller,A. Richard Rutter,Paul F. Chapman +5 more
TL;DR: Comparing the antidepressant-like effects of 5-HT(6) antagonists with donepezil is compared to determine whether their different effects on monoamines are behaviorally relevant, and data suggest that 5- HT( 6) antagonists, at doses corresponding to those occupy central 5-ht(6), receptors, could have an antidepressive effect in humans.
Journal ArticleDOI
Effect of different restraint schedules on the immobility in the forced swim test: Modulation by an opiate mechanism
TL;DR: Evaluating the influence of different stress schedules on behaviors displayed during both phases of the forced swim test found naloxone administered before each of the seven restraint events blocked the higher immobility observed in chronically stressed rats during the retest period suggesting the involvement of an opiate mechanism.
Journal ArticleDOI
Dual monoamine modulation for the antidepressant-like effect of lamotrigine in the modified forced swimming test.
TL;DR: The present study indicates that the antidepressant-like effect of lamotrigine is probably related to noradrenergic/serotonergic systems.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more