Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Journal ArticleDOI
Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission.
Christina Dalla,Katerina Antoniou,Nikolaos Kokras,G. Drossopoulou,G. Papathanasiou,Stathis Bekris,S. Daskas,Zeta Papadopoulou-Daifoti +7 more
TL;DR: The findings show that FST and CMS have different effects on the dopaminergic activity of discrete brain regions depending on the sex of the animal, and support the growing evidence that females display a differential response and adaptation to stress than males.
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Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats
TL;DR: The findings suggest that NO might be an important modulator of depression in rats, as well as a test for screening new antidepressant agents.
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The WAG/Rij strain: A genetic animal model of absence epilepsy with comorbidity of depressiony
TL;DR: Evidence is provided that WAG/Rij rats can be regarded as a valid genetic animal model of absence epilepsy with comorbidity of depression and might represent a model of chronic low-grade depression (dysthymia).
Journal ArticleDOI
Problems with current catecholamine hypotheses of antidepressant agents: Speculations leading to a new hypothesis
TL;DR: A new formulation, the output hypothesis, which is derived from the foregoing theories, is proposed, and assumes that depression or adverse behavioral effects of stress results when the output of brain cells bearing noradrenergic receptors is too low to meet increased demand resulting from stress or other biologically disruptive events.
Journal ArticleDOI
Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist
Luigi Cervo,Rosario Samanin +1 more
TL;DR: The results show that 8-OH-DPAT, by acting on serotonin neurons in the brain, produces disinhibitory effects in a rat model predictive of antidepressant activity and suggest that serotonin1A agonists such as 8- OH- DPAT could constitute a novel class of rapid-acting antidepressant agents.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more