Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors.
Bernard Vacher,Bernard Bonnaud,Philippe Funes,Nathalie Jubault,Wouter Koek,Marie Bernadette Assié,Cristina Cosi,Mark S. Kleven +7 more
TL;DR: The results indicated that, after a single oral administration, these compounds inhibited immobility in the FST more potently and more extensively than the clinically used antidepressant imipramine.
Journal ArticleDOI
Central nervous system activity of acute administration of isopulegol in mice.
Maria Izabel Gomes Silva,Manuel Rufino de Aquino Neto,Paulo Florentino Teixeira Neto,Brinell Arcanjo Moura,Jeferson Falcão do Amaral,Damião Pergentino de Sousa,Silvânia Maria Mendes Vasconcelos,Francisca Cléa Florenço de Sousa +7 more
TL;DR: The results showed that isopulegol presented depressant- and anxiolytic-like effects in animal models of open field, elevated plus maze, rota rod, hole board, barbiturate-induced sleeping time, tail suspension and forced swimming tests in mice.
Journal ArticleDOI
Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.
TL;DR: It is concluded that available data are insufficient to strongly support the notion that FG7142 and beta-CCE are the anxiogenic drugs “par excellence” they are often claimed to be.
Journal ArticleDOI
Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.
Miguel Coleta,Maria Gabriela Nogueira Campos,Maria Dulce Cotrim,Thereza Christina Monteiro de Lima,António Proença da Cunha +4 more
TL;DR: The findings suggest a possible interaction with other neurotransmitter systems but cannot rule out the possibility that luteolin's metabolites might show a higher affinity for the BDZ-R in vivo, thus eliciting the evident anxiolytic-like effects through a GABAergic mechanism.
Journal ArticleDOI
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression
Andrew Harkin,John P. Kelly,Mairéad G McNamara,Thomas J. Connor,Keith Dredge,A. M. Redmond,Brian E. Leonard +6 more
TL;DR: Results indicate that changes to 8-OH-DPAT and clonidine-induced responses occur quicker with the combination treatment than with either reboxetine or sertraline treatments alone, and also indicates changes to 5-HT1A receptor and alpha2-adrenoceptor sensitivity.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more