Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants.
TL;DR: This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
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The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.
TL;DR: The tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression.
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The validity of animal models of depression.
TL;DR: The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
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Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
TL;DR: The evidence supports the hypothesis that under certain circumstances rats can become sugar dependent and may translate to some human conditions as suggested by the literature on eating disorders and obesity.
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The spectrum of behaviors influenced by serotonin
TL;DR: The diverse array of behavioral effects of serotonin form the basis for understanding its potential role as an etiological marker in psychiatric disorders and for the successful pharmacologic intervention of drugs regulating serotonin neurotransmission in behavior.
References
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Journal Article
[Antidepressant therapy by sleep deprivation (author's transl)].
Rudolf Ga,Schilgen B,Tölle R +2 more
Journal ArticleDOI
Controlled Trial of Nomifensin (HOE 984) and Viloxazine in the Treatment of Depression in the Elderly
TL;DR: The new antidepressant nomifensin (Hoechst 36984), a drug which showed less cardiotoxicity than tricyclics, was compared in a single-blind comparative trial with viloxazine to show statistically significant improvement with both treatments.
Journal ArticleDOI
A double blind comparative trial of nomifensin and desimipramine in depression. Relationship between treatment and phenylethylamine excretion.
TL;DR: Nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes.
Journal Article
Clinical and pharmacological effects of treatment with a new antidepressant.
Coppen Aj,Ghose K +1 more
TL;DR: The novel tetracyclic piperazino-azepine compound Org GB 94 in a dose of 20 mg three times daily was found to be of save markedly and significantly less side-effects and reponded equally well to patients with reactive depression and those with endogenous depression.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more