Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Journal ArticleDOI
Auditory and vestibular defects in the circling (ci2) rat mutant.
Alexander Kaiser,Maren Fedrowitz,Ulrich Ebert,Elke Zimmermann,Hans-Jürgen Hedrich,Dirk Wedekind,Wolfgang Löscher +6 more
TL;DR: The histological findings in mutant circling rats strongly indicate that the hearing loss of the mutants is of the sensory neural type, the most prevalent type of hearing loss.
Journal ArticleDOI
Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions
TL;DR: Comparison studies in these lines may help to develop novel working hypotheses on the relationships among genotype, temperament traits, and neural mechanisms underlying the vulnerability or resistance to stress-induced depression in humans.
Journal ArticleDOI
Monocyte mediated brain targeting delivery of macromolecular drug for the therapy of depression
Jing Qin,Xu Yang,Ruo-Xi Zhang,Yi-Xiao Luo,Jia-Li Li,Jia Hou,Chun Zhang,Yongji Li,Jie Shi,Lin Lu,Jianxin Wang,Wei-Li Zhu +11 more
TL;DR: In an effort to treat depression, brain targeted delivery via monocyte-cRGD liposome complexes capable of crossing the intact BBB was performed in a murine model and similar approaches may be helpful in the treatment of other neuropsychiatric conditions.
Journal ArticleDOI
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression
TL;DR: The juvenile FST accurately predicts the efficacy of selective serotonin reuptake inhibitors and the lack of efficacy of tricyclic antidepressants in the treatment of depression in children and adolescents, and suggests that the FST using 21-day-old rats may help to develop better treatments for childhood and adolescent depression.
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Repeated exposure to chlorpyrifos alters the performance of adolescent male rats in animal models of depression and anxiety.
TL;DR: The data suggest that repeated exposure to CPF elicits alterations of the emotional behaviors related to serotonergic nervous system in adolescent male rats, however, the underlying mechanism needs further investigations.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more